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Register a new userP53:Its Role As Gardian of The Genome and in Apoptosis and Antioncogenesis
p53:دوره في حراسة المحتوى المورثي و في الاستماتة الخلوية و كبح التسرطن (مراجعة في الأدب الطبي)
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Damascus University ورقة بحثية
Publication date
2012
fields
Dentistry
and research's language is
العربية
Authors
مايا بسام الجوخدار( باحث )
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Shamra Editor
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يعد البروتين p53 حارساً لمحتوى الخلية المورثي من أي تبدل، و وصفت المورثة التي تنتجه بالكابحة للورم. يتحقق البروتين من وجود أي خلل في دورة الخلية، و في حال وجود الخلل يسهم ال p53 بإصلاحه و تحفيز نسخ بعض البروتينات المهمة في الإصلاح، و في حال إخفاق الخلية في الإصلاح فإنه يقودها للاستموات. خروج الخلية عن هذه السلسلة الطبيعية و استمرارها بالمقاومة و التكاثر يجعلها خلية و رمية مما يجعل ال p53 موضوعاً دراسياً عالي الأهمية.
P53 is the guardian of genome from any alteration, its gene is called tumor suppressor gene . p53 checks any alteration in cell cycle ,and if the alteration happened p53 resolves or shares in activation proteins important in resolving , if the cell couldn't resolve the alteration p53 leads it to apoptosis . goingthe cell out of this nature cycle and continuing its resistance and proliferation makes it a tumor celland that make p53 very important study.
References used
Lentsch E.J, Myers J.N. pathogenesis and progression of squamous cell carcinoma of head and neck .Myers E.N, Suen J.Y, Hanna E . Cancer of the Head and Neck. 4TH ed . USA: Saunders Elsevier; 2000:13
Stewart Z.A, Pietenpo J.A. p53 signaling and cell cycle checkpoint ,invited review. Chem Res Toxicol 2001; 14(3): 243-263
Hollstein M, Sidransky D, Vogelstein B,Harris C. p53 mutations in human cancers. Science 1991;253: 49- 53
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