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Register a new userInvestigating the pathway of protein p53 inhibition in head and neck squamous cell carcinoma (Immunohistochemistry study)
تحري سبيل تعطل البروتين p53 في السرطان شائك الخلايا للرأس و العنق (دراسة كيميانسيجية مناعية)
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Damascus University ورقة بحثية
Publication date
2011
fields
Dentistry
and research's language is
العربية
Created by
Shamra Editor
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يعد البروتين p53 حارساً لمحتوى الخلية المورثي من أي تبدل، و وصفت المورثة التي تنتجه بالكابحة للورم التي تطفر في 50 % من حالات السرطان الشائك الخلايا منتجة بروتيناً طافراً. لم تفصل الدراسات في نسبة تعبيرية البروتين الطافر في الخلايا السرطانية و لم تتناول الحالات التي لا تُظهر بروتيناً طافرَا. التحري عن البروتين السليم في عينات السرطان شائك الخلايا للرأس و العنق.
The protein p53 is the guardian of the cell gene contents from changes, and the gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell carcinoma’s cases producing defective protein .Studies have not detailed the expression ratio of the defective protein Within the cancer cells, also studies have less details about the cases which did not show a mutated protein.
References used
Marron M;Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol 2010;39:182–196
Jemal A, Bray B, Melissa M. , Ferlay J, Ward E, Forman D. Global Cancer Statistics. Ca Cancer J Clin 2011;61:69–90
Neville et.al. Epithelial pathology .Oral and Maxillofacial Pathology; 3ED ed . USA :Saunders Elsevier; 2002:409-421
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this study Aimes to Investigate CXCR4 expression in primary head
and neck squamous cell carcinomas tumors in all clinical stages and
histological grades, then compare it with control normal oral
epithelial tissues.
Compare metastatic lymph nodes
CXCR4 expression with their
primary HNSCC tumors at high stages which associated with
metastatic lymph nodes.
Squamous cell carcinoma SCC is an important malignancy in
head and neck tumors , Its high stages resulting in poor survival
because of metastasis–especially lymph nodes- and secondary
tumors . lymph nodes LN have biological importance because of
their immunity role as a base of immunity defensive lines and lymphatic fluid purification, Recently chemokine receptors have been reported to be correlated with many malignancies ,In
particular CCR7.
Background & Objective: This immunohistochemical study is to investigate the correlation between p53 & Ki67 and the grade of malignancy of squamous cell carcinoma, to estimate functional behavior of the cancerous cell by Ck17, and to compare the resu
lts with the histological grading.
Methods & Materials: 64 samples (biopsies) were chosen to check for p53, Ki67 & Ck17 at department of oral histology and pathology between 2002- 2009.
Conclusion: There is a strong positive correlation between the degree of malignancy and the signs of cellular atypism (morphological changes) and the immunhistochemical positivity specially p53 and Ki67, and there is a strong negative correlation between the positivity of p53, Ki67 and the plasmolymphatic
infiltrate. We must be sure of the correct diagnosis of squamous cell carcinoma by histological and immunohistochemical examination, and attention should be given to use more than one immune reactive.
Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
Cancer of the lip is relatively common malignancy of the head and neck region.
Squamous cell carcinoma most frequently occurs in the lower lip (LLSCC) or Lower Lip Squamous Cell
Carcinoma. This study aimed to evaluate the correlation between the in
volved lymph nodes level and the
tumor appearance, greatest dimension (T) and its degree of differentiation.
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