CpG islands play an important role in genes transcription regulation, due to the fact that these islands overlap with the genes’ promoter regions, and the methylation of those CpG islands may repress the transcription of the associated genes. Previou
s studies reported that
methylation of CpG islands is an important indicator of the presence and possibility of
developing cancers. There are mainly two types of algorithms to identify CpG islands in the nucleotides sequences: distance-based and sliding-window algorithms. The outputs of these algorithms are different for the same nucleotide sequence. The aim of this study is to compare the performance of the above mentioned algorithms by using two web tools named CpGCluster and newCpGReport.
CpG islands in human chromosome 22 were identified by applying the two algorithms on this chromosome, and the variation in the number and length of the identified islands was clear.
The results also show that about 60% of both tools’ output is crossed. Moreover, the effect of the traditional parameters of CpG islands (length, C+G content and Observed/expected ratio)
on the number of the identified islands was studied. The results show that the length parameter has a great effect on the number of islands identified by newCpGReport, while it does not affect CpGCluster’s performance. The effect of making CpG islands identified by
newCpGReport start and end with CpG was also studied, due to this operation C+G content and Observed/expected ratio increased for most islands, taking into account that 25% of the islands became shorter than 200 nucleotides.
we delivered 8,000 IU epoetin three times per week to 30 anemic cancer patients for two months.we measured serum erythropoietin level before the initiation of the treatment.Hemoglobin concentration and other hematological parameters were measured dur
ing the treatment. 53% of patients responded to the treatment within 8 weeks. 71% of patients with serum erythropoietin < 100 U/L responded, whereas 27% with values > 100 U/L did.80% of patients with hematological malignancies responded, whereas 39% of patients with solid tumors did .Reticulocyte increment after two weeks in responder patients was higher than non responders.response rate was higher in patients with Hb increment > 0.5 g/dL after 2 weeks ( 83% versus 31% ), and in those with Hb increment > 1 g/dL after 4 weeks ( 93% versus 14% ). response to erythropoietin can be predicted by pretreatment serum erythropoietin level together with early changes in other hematological parameters.
This research aims to developing new method for breast tumors extraction and
features detection in breast magnetic resonance images by depending on clusteringand
image processing algorithms. At the beginning, one of clustering algorithms was used f
or
image segmentation and grouping pixels by their gray scale values. Then morphological
operations were implemented in order to remove noise and undesired regions, after that
suspected areas were extracted. Finally some shape features for extracted area were
detected, this features could be very useful for tumors diagnosis. A database consisted of
96breast magnetic resonance images were used and proposed approach was appliedby
MATLAB program, and we obtainedbreast tumors extraction and its features and
compared them with the doctor's opinion .
The study is carried out to estimate the efficiency of Procalcitonin in the diagnosis of
bacterial infection in cancer patients at Chemical and Radiation Therapy Center in
Tishreen University Hospital in Lattakia between 3/1/2015-28\3\2016.
This s
tudy has included 45 patients, 25 with infection and 20 without infection, all of
them have a fever and don't take antibiotics. The all of patients has undergone a
comprehensive initial assessment included history, physical examination, biochemical
parameters and X-ray images.
Procalcitonin was also measured during fever and compared with C-reactive protein
CRP, the results indicated that there is a significant correlation between Procalcitonin and
infection, where the median values Procalcitonin in patients with infection 16.9 ng/ml
compared to 0.7 ng/ml in patients without infection, Procalcitonin concentration was also
associated with the severity of the infection, the study showed that the Procalcitonin is
more sensitive and specific of the CRP in diagnosing of sepsis in cancer patients.
Oral complications are common in patients with cancer who
undergo chemotherapy treatment. Not all patients are at equal risk
for developing oral complications. A number of variables have been
identified that bear on both the frequency and severity
of oral
problems associated with therapy. These can be divided into those
that are associated with the patient and those that are related to the
treatment regimen. In this study we have studied the effect of
patient age and gender on the oral complications in group of patients
who undergo chemotherapy treatment. We conclude that aging can
affect some oral complication chemotherapy like xerostomia and
taste changes whereas gender has it effect on pain and oral sence
disorders mainly in males.
Serglycin is an intracellular proteoglycan in hematopoietic cells. It
has been studied in normal and tumor hematopoietic cell, so it was
suggested to have an important role in immunity and cancers as leukemia.
The challenge to make a diagnosis for
acute leukemia and to
differentiate between myeloid or lymphoblastic leukemia, is the reason
we go to assay concentration of serglyc in normal people and
patient with acute myeloid leukemia and acute lymphoblastic leukemia
from children and adult at hematology department in the
main hospitals in Damascus ( Pediatric’shopital, Almouasat and Al
asaad hospital) before beginning any kind of treatment and studying
the relation with white blood cells count. We found clear difference
between the concentration in patient with acute leukemia and normal
people. There was a high level of this marker in paint with
AML in contrast with ALL patients. We found a relation between
concentration of serglycin and the count of white blood cells.
Background: cancer patients experience large physical and emotional challenges
related to side effects of chemotherapy drugs, which make coping and adaptation essential
issue for coping with disease. Aim: this study was conducted to identify coping
strategies
among cancer patients during chemotherapy and its relation with patient's age and gender
Methods: data were collected from 150 patients from Tishreen university hospital by using
brief coping questionnaire in addition to demographical sheet Results : the results
revealed that cancer patients tend to use various coping strategies which are problemfocused
and emotional- focused, reflected positive and negative coping. The most used
coping strategies were active coping strategy (78.66%), followed by seeking social support
for instrumental reasons strategy (76.66%), followed by planning strategy (76%), then
focus on and venting of emotions (75.33%), followed by acceptance strategy (70.66%),
then seeking social support for emotional reasons (68%), then turning to religion (58%).
Also results showed that coping strategies changed according to age and gender changing
(p < 0.05) where women tend to use emotional- focused coping strategies while aged
patients prefer emotional social support and acceptance. Conclusion: emotional issues for
cancer patients during chemotherapy require more concern with ongoing assessment for
adaptation and coping strategies, for designing appropriate interventions agreed with
coping behaviors which cancer patients demonstrate during treatment.
