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Register a new userStudying the level of Serglycin in Patient with Acute Leukemia
دراسة مستويات السيرغليسين عند مرضى الابيضاض الحاد
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السيرغليسين بروتيوغليكان داخل خلوي هام في الخلايا الدموية. تمت دراسته في خلايا دموية طبيعية و ورمية . لذلك وصف دوره في المناعة و الأورام و منها الابيضاضات, إن ما نجده من تحد في تشخيص الابيضاض الحاد و التمييز بين نوعيه النقوي و اللمفاوي, دفعنا لقياس تركيز السيرغليسين عند مرضى الابيضاض النقوي الحاد و اللمفاوي الحاد من أطفال و بالغين مقيمين في شعبة أمراض الدم في المشافي الجامعية (الأطفال و المواساة و الأسد) و ذلك قبل تلقي أي علاج, و دراسة علاقته مع تعداد الكريات البيضاء. فكان هناك فرق واضح في تراكيزه عند مرضى الابيضاض الحاد و الأشخاص السليمين, و ارتفاع في تركيزه عند مرضى الابيضاض النقوي الحاد مقارنة بتركيزه عند مرضى الابيضاض اللمفاوي الحاد. و وجدنا علاقة بين تركيزه و تعداد الكريات البيضاء .
Serglycin is an intracellular proteoglycan in hematopoietic cells. It has been studied in normal and tumor hematopoietic cell, so it was suggested to have an important role in immunity and cancers as leukemia. The challenge to make a diagnosis for acute leukemia and to differentiate between myeloid or lymphoblastic leukemia, is the reason we go to assay concentration of serglyc in normal people and patient with acute myeloid leukemia and acute lymphoblastic leukemia from children and adult at hematology department in the main hospitals in Damascus ( Pediatric’shopital, Almouasat and Al asaad hospital) before beginning any kind of treatment and studying the relation with white blood cells count. We found clear difference between the concentration in patient with acute leukemia and normal people. There was a high level of this marker in paint with AML in contrast with ALL patients. We found a relation between concentration of serglycin and the count of white blood cells.
References used
Deschler B, Lubbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer. 2006;107(9):2099-107. Epub 2006/10/05
Haferlach T, Kern W, Schnittger S, Schoch C. Modern diagnostics in acute leukemias. Critical reviews in oncology/hematology. 200.34-223:)2(56;5
Kolset SO, Pejler G. Serglycin: a structural and functional chameleon with wide impact on immune cells. J Immunol. 2011;187(10):4927-33. Epub 2011/11/04
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