Prevalence of Hypogonadism in β-Thalassemia Major Patients from Gaza Strip

This study was conducted to determine the prevalence of hypogonadism among β-Thalassemia Major (β-TM) adolescent patients, and the role of iron chelation therapy (ICT) in its prevention. Data was collected from 60 β-TM patients and 35 controls aged 13─ 30 years through a questionnaire and a review of medical history to collect sociodemographic characteristics, transfusion regimen, chelating history and pubertal status. Complete blood count, serum ferritin, and pituitary-gonadal function tests were analyzed 1–2 weeks after blood transfusion. Logistic regression, independent t-test, and chi-square test were used to analyze our results and the significance was tested at p≤ 0.05. The overall prevalence of hypogonadism among β-TM patients was 75%, the mean of serum ferritin was 6704.83± 2849 ng/ml and all patients had serum ferritin above 2000 ng/ml indicating a severe iron overload. Low hemoglobin level (p=0.006), high ferritin level (p=0.018), high blood transfusion per year (24-blood transfusions) (p=0.007), and poor compliance to iron chelation therapy programs (p=0.001), were detected had significant partial effect in hypogonadism. In conclusion, hypogonadism is highly prevalent among Gaza strip β-TM patients. Its presence being associated with lower hemoglobin values, iron overload, high blood transfusion and low compliance of iron chelation therapy

Detection and Quantification of Iron in Liver and Myocardium using MRI

MRI is a medical imaging method that does not use harmful or ionizing radiation so it is safe and can be used to measure the proportions of iron that accumulate in the organs of the human body, especially the heart and liver

Kinetics Study, and Proposed Mechanism for the Photochemical Reduction of Chromium (VI) by Iron(III)-mandelic acid Complexes in Aqueous Solutions

تناول البحث الحالي دراسة تفاعل الإرجاع الفوتوكيميائي للكروم السداسيّ المستحثّ بوساطة معقّدات مانديلات الحديد الثلاثيّ في المحاليل المائيّة. و تمّ إجراء تجارب مقارنة من أجل تحديد الشروط المثلى لتفاعل الإرجاع الضوئي للكروم السداسيّ في الجملة:؛ حيث دُرست تأثيرات كلّ من: - الوسط و التراكيز الابتدائيّة للمكوّنات المختلفة؛ الحديد الثلاثيّ و حمض المانديليك و الكروم السداسيّ، على فعالية إرجاع الكروم السداسيّ. أظهرت النتائج التجريبيّة أنّه يمكن لمعقّد مانديلات الحديد الفعّال ضوئياً إرجاع الكروم السداسيّ باستخدام الضوء فوق البنفسجي/ المرئي ، و أنّ قيمة المُثلى للإرجاع الفوتوكيميائي للكروم السداسيّ بوساطة هذا المعقّد تبلغ نحو . و تبيّن أنّ فعالية الإرجاع الضوئي للكروم السداسيّ تزداد بازدياد التراكيز الابتدائيّة لكلّ من الحديد الثلاثيّ و حمض المانديليك، و لكنّها تتناقص كلّما ازدادت التراكيز الابتدائيّة للكروم السداسيّ. و قد تمّ اقتراح آليّة محتملة لتفاعل الإرجاع الضوئي للكروم السداسيّ بوساطة معقد مانديلات الحديد الفعّال ضوئياً في المحلول المائي.

Evaluation the role of Hepcidin in predicting nonresponsiveness to oral iron therapy among iron deficient anemic patients

Worldwide, iron deficiency anemia (IDA) is the most common nutritional deficiency, and its management remains a challenge in many cases.(OIT)Oral iron therapy, in appropriate doses and for a sufficient duration, is an effective first-line strategy for most patients. But some patients do not experiencean optimal response to(OIT).The need is still current and clinically relevant for predictors of response to OIT. Hepcidin-25, a major regulator of iron metabolism, may be use as a reliable guide for the use of iron and be one of them.112 patientswith IDA were enrolled in this follow up clinical trial, Selected from two university, hospitals in Damascus between JUNE2015 and JUNE2016. For patients who met the inclusion criteria, Baseline CBC, iron studies, and serum hepcidin-25 were measured, and then they received a 14-day course of oral iron (ferrous gluconate 325mg/ 3 times daily). Patients who achieved <1g/dl increase in Hb in 14 days were categorized as “nonresponders”. Screening hepcidin levels were (40.18± 86.35) versus (6.37±10.37)(p= 0.041(innonresponders versus responders to oral iron trial. HepcidinCutoff of >14.3 ng/ml, showed sensitivity of 40%,specificity of 90.2%, andpositive predictive value of 60% andnegative predictive value of 80% for predicting nonresponsiveness to oral iron.We conclude that serum hepcidin25predicts poorly nonresponsivenesstooral iron therapy in IDA patients, but it is superior to ferritin and TSAT for this purpose.

Study of Correlation of Serum Hepcidin with Iron Status Markers and Hematological Indices among Iron Deficient Anemic patients and healthy controls in Damascus : A Case-Control Study

Hepcidin-25 is a peptide hormone plays an important role in regulating the systematic iron homeostasis. This paper was conducted to study the correlations of Hepcidin with some iron status markers and red cell indices among patients with iron deficiency anemia (IDA) and healthy controls in Damascus. Our study comprised 20 IDA patients (Hb≤11 g/dl for men and women,Tsat≤20% and ferritin <30 ng/dl) and 10 healthy non IDA controls. Complete hemogram was performed, iron status markers (serum iron, total iron binding capacity and ferritin) were measured and transferrin saturation was calculated .

اصطناع الجمل الثنائية MO-Fe2O3 حيث M= Ba,Zn بطريقة الترسيب المشترك ودراسة بنيتها وخواصها

قمنا في هذا البحث باصطناع كل من مركبي فرات الباريوم وفرات الزنك بلون بني محمر وذلك بطريقة الترسيب المشترك

Detection of some Heavy Metals in the Locally-Processed Spices

This study has been conducted to identify the levels of heavy metals (lead, cadmium, nickel, cobalt, copper, iron, manganese, and zinc) in the following spices: Nutmeg, turmeric, cinnamon, ginger, cardamom, nigella sativa, black pepper, cumin, coriander, curry, and mixed spices.

Ferrous complexes with aromatic α-substituted tris(2-pyridylmethyl)amine ligands: effect of the substituents and biomimetic reactivity

Biomimetic oxidations at active sites of iron proteins involve peroxides, especially hydrogen peroxide which is a strong and very convenient reagent since it is inexpensive and does not release any toxic by-products. In many cases however, mother Nature uses molecular dioxygen to carry out major oxidation reactions in particularly attractive conditions. The biomimetic interest of iron complexes in the tris(2-pyridylmethyl)amine series TPA is no longer to demonstrate. We prepared various α-substituted TPA-based ligands with the idea to modulate the electronic properties at the metal centre. We then checked the reactivity of a one example of complexes towards molecular dioxygen.

Spectrophotometric Study of Iron(III)-Lactic Acid Complexes, and Suggested Mechanism for the Photoredox Reaction of the Complex

The spectral characteristics of the iron(III) lactate complexes were examined by the spectrophotometric methode, and the absorbance of these complexes has been studied at diferente wavelengthes . The stoichiometry of the photoreactive complex formed in the iron(III)-lactate system has been investigated in aqeuous solution under determinative experimental conditions. Initial concentrations whether of Iron(III) or of lactic acid ranged from to , and -values were belonging to the range . The results showed, that the ratio of iron(III) to lactate in the photoreactive complex is 1:2, i.e. its formula is . This complex has a maximum absorption at 365 nm. Its molecular absorption coefficient is about ≈ and its dissociation constant is about . The tentative mechanism for the photochemical decomposition of the complex has been suggested, in agreement with the reference studys . The suggested mechanism depends on the relationship between the absorbance and the photoreaction kinetics, and it is not based on the qualitative or quantitative analysis of reaction products.

The Relationship between anemia and milk feeding in infants aged 6 months to 2 years in Tishreen and ALassad hospitals

Objective: To determine if there is a relationship between milk feeding and iron deficiency anemia ,and to determine the association between anemia and infant birth order, time of introduction solid foods, socioeconomic state , Birth weight less than 3000 gram . Methods: A total of 300 children between 6 and 24 months old were attended at Alassad and TISHREEN Hospitals were enrolled in the Study during the period July 2015-July 2016,a patient –case study ,patient definition:an infant with anemia ,case definition:an infant without anemia we calculated the odd ratio with confidence intervals 95%,we used chi-square and TStudent test. Results: by studying the relationship between anemia and milk feeding we found the odd ratio=5.6,it means that the risk to have anemia is 6 times more in infants consumping breast milk.by using chi-square test to study the relationship between anemia and both of infant order,socioeconomic state,the resuts were :there is no association between birth order and anemia but there is a big association between anemia and socioeconomic state.the result of studying the relationship between taking iron complemnts and anemia :the risk of anemia is 2 times more in infants who do not take iron ccomplemnts.there was no relationship between introducing solid foods before the age 6 months and having anemia .there was no association between low birth weight infants and having anemia.