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Register a new userThe Rule of Cathepsin Bin the Tumor Environment in Patients with Breast Cancer
دور الكاثبسين B في بيئة الورم عند مريضات سرطان الثدي
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مرام ياسين بلال( باحث )
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اهدف الدراسة: دراسة التعبير عن الكاثبسين B (أحد الأنزيمات الحالة للبروتين) في نسج بشرية من سرطان الثدي، و ربط النتائج مع المعلومات المتوفرة عن الورم. المواد و الطرق: تمت الدراسة على 23 عينة نسيجية من سرطان الثدي مثبتة بالفورم ألدهيد و مغمورة بشمع البارافين، حيث جُمعت العينات من مشفى الأسد الجامعي و مخبر خاص للتشريح المرضي في محافظة اللاذقية، و باستخدام تقنية التلوين المناعي النسيجي تم التحري عن الكاثبسين B في النسج السرطانية، و استخدم نسيج اللوزة كشاهد إيجابي للتلوين بالأضداد. النتائج: ظهر التعبير السيتوبلاسمي للكاثبسين B في نسيج اللوزة في البالعات المتواجدة في المراكز المنتشة إضافة إلى الخلايا البطانية للأوعية الدموية. لوحظ لدى تلوين عينات سرطان الثدي تلون كل من الخلايا الورمية و الخلايا البطانية و الخلايا المناعية المتسللة في السدى. و قد ارتبط تعبير الخلايا البطانية عن الكاثبسين B بعلاقة هامة إحصائياً مع درجة الورم (p=0.049). الاستنتاجات: أظهرت الدراسة دور الكاثبسينB في تحفيز تشكل الأوعية الجديدة في الورم، و يبقى تحديد العوامل الالتهابية التي تزيد فعالية الكاثبسين B هاماً في تحديد بعض الجزيئات التي يمكن استخدامها كأهداف جزيئية جديدة لعلاج السرطان.
Aim: to assess the expression ofcathepsin B(ctsB; an important protease) in human breast cancer and correlate that with the tumor grade. Materials and Methods:Serial sections were obtained from 23 formalin-fixed paraffin embedded breast cancer tissue specimens which were collected from Alasad University Hospital and a pathological laboratory in Lattakia - Syria. Tissues were stained for cathepsin B using immunohistochemistry. Tonsil tissues were also included as a positive control. Results:Positive cytoplasmic staining of CtsB was observed in both follicular macrophages and endothelial cells in tonsil sections. In breast cancer tissues, tumor cells, endothelial cells and stroma stained positive for CtsB. The presence of CtsB in blood endothelium significantly correlated with the tumor grade (p=0.049). Conclusion: These results supported the important role of cathepsin B in tumor progression, particularly in angiogenesis. Future studies should investigate the regulating mechanisms of cathepsin activities within the tumor environment, and that can be considered as new tagets for cancer treatment.
References used
BARTHELL E, MYLONAS I, SHABANI N, KUNZE S, KUHN C, JESCHKE U, AND FRIESE K. ImmunohistochemicalVisualisation of Cathepsin-D Expression in Breast Cancer. Anticancer Research 2007; 27: 2035-2040
BRIOZZO P, BADET J, CAPONY F, PIERI I, MONTCOURRIER P, BARRITAULT D, AND ROCHEFORT H. MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: a permissive role of cathepsin D. Exp Cell Res. 1991; 194(2): 252-259
CASTIGLIONI T, MERINO M, ELSNER B, LAH T, SLOANE B, AND EMMERT-BUCK M. lmmunohistochemical Analysis of Cathepsins D, B, and L in Human Breast Cancer. Human Pathology1994; 25( 9): 857-862
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