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The immune role of Bcl2 antibodies in Syrian breast cancer pateints after treatment

الدور المناعي لأضداد Bcl2 لدى مريضات سرطان الثدي السوريات بعد المعالجة

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 Publication date 2014
  fields Pharmacy
and research's language is العربية
 Created by Shamra Editor




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recurrence is a major problem which affects 40% of Breast cancer patients . Bcl2 is an antiapoptotic protein which is implicated in many cases of cancer development and cancer resistance to therapy. Aim of study : investigate the role of Bcl2 in recurrence in Breast cancer patients


Artificial intelligence review:
Research summary
تتناول هذه الأطروحة الدور المناعي لأضداد Bcl2 لدى مريضات سرطان الثدي السوريات بعد المعالجة. يهدف البحث إلى دراسة تأثير بروتين Bcl2 على النكس واستجابة المريضات للعلاج. تم جمع عينات دم من 60 مريضة بسرطان الثدي قبل وبعد العلاج، بالإضافة إلى 25 عينة من سيدات سليمة كعينة شاهدة. أظهرت النتائج ارتفاع مستويات Bcl2 المصلي لدى المريضات مقارنة بالمجموعة الشاهدة، وارتبطت المستويات العالية من Bcl2 بزيادة احتمالية النكس. كما وجدت الدراسة أن المستويات العالية من Bcl2 تترافق مع انخفاض في عيارات الأضداد المناعية الذاتية مثل anti-dsDNA antibodies. توصلت الدراسة إلى أن بروتين Bcl2 يلعب دورًا هامًا في النكس وقد يكون له تأثير سلبي على المناعة الذاتية لدى المريضات.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة هامة في فهم الدور المناعي لبروتين Bcl2 في سرطان الثدي، إلا أنها تحتوي على بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة المستخدم قد يكون غير كافٍ للوصول إلى نتائج قابلة للتعميم على نطاق أوسع. ثانياً، لم يتم التطرق بشكل كافٍ إلى العوامل البيئية والوراثية التي قد تؤثر على مستويات Bcl2 والمناعة الذاتية. ثالثاً، كان من الممكن استخدام تقنيات تحليلية أكثر تقدمًا لتحليل البيانات بشكل أعمق. على الرغم من هذه النقاط، فإن الدراسة تقدم رؤى قيمة حول دور Bcl2 في سرطان الثدي وتفتح المجال لمزيد من الأبحاث في هذا المجال.
Questions related to the research
  1. ما هو الهدف الرئيسي من هذه الدراسة؟

    الهدف الرئيسي هو دراسة الدور المناعي لبروتين Bcl2 في حدوث النكس لدى مريضات سرطان الثدي السوريات بعد المعالجة.

  2. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    النتائج الرئيسية هي أن مستويات Bcl2 المصلي كانت مرتفعة لدى المريضات مقارنة بالمجموعة الشاهدة، وأن المستويات العالية من Bcl2 تترافق مع زيادة احتمالية النكس وانخفاض في عيارات الأضداد المناعية الذاتية.

  3. ما هي التوصيات التي قدمتها الدراسة؟

    توصي الدراسة ببحث دور الأضداد المناعية باستخدام طيف أوسع من الأضداد، واستخدام مقايسة Bcl2 المصلي كمؤشر على النكس، وإجراء دراسات أوسع لتحديد أهمية Bcl2 في الممارسة السريرية.

  4. ما هي العوامل التي لم يتم التطرق إليها بشكل كافٍ في الدراسة؟

    لم يتم التطرق بشكل كافٍ إلى العوامل البيئية والوراثية التي قد تؤثر على مستويات Bcl2 والمناعة الذاتية.


References used
IARC: international Agency for Research on cancer: World cancer Report 2012 Breast cancer Estimated Incidence
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