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Register a new userThe immune role of Bcl2 antibodies in Syrian breast cancer pateints after treatment
الدور المناعي لأضداد Bcl2 لدى مريضات سرطان الثدي السوريات بعد المعالجة
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Added by
Damascus University رسالة ماجستير
Publication date
2014
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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يعتبر حدوث النكس من المشاكل الهامة التي تظهر عند 40% من مريضات سرطان الثدي . تم تعرف Bcl2 كبروتين مضاد للاستماتة وتم الربط بينه وبين العديد من حالات تطور السرطان ومقاومة المرض على العلاج وتهدف هذه الدراسة إلى بحث دور Bcl2 في حدوث النكس لدى مريضات سرطان الثدي.
recurrence is a major problem which affects 40% of Breast cancer patients . Bcl2 is an antiapoptotic protein which is implicated in many cases of cancer development and cancer resistance to therapy. Aim of study : investigate the role of Bcl2 in recurrence in Breast cancer patients
Artificial intelligence review:
Research summary
تتناول هذه الأطروحة الدور المناعي لأضداد Bcl2 لدى مريضات سرطان الثدي السوريات بعد المعالجة. يهدف البحث إلى دراسة تأثير بروتين Bcl2 على النكس واستجابة المريضات للعلاج. تم جمع عينات دم من 60 مريضة بسرطان الثدي قبل وبعد العلاج، بالإضافة إلى 25 عينة من سيدات سليمة كعينة شاهدة. أظهرت النتائج ارتفاع مستويات Bcl2 المصلي لدى المريضات مقارنة بالمجموعة الشاهدة، وارتبطت المستويات العالية من Bcl2 بزيادة احتمالية النكس. كما وجدت الدراسة أن المستويات العالية من Bcl2 تترافق مع انخفاض في عيارات الأضداد المناعية الذاتية مثل anti-dsDNA antibodies. توصلت الدراسة إلى أن بروتين Bcl2 يلعب دورًا هامًا في النكس وقد يكون له تأثير سلبي على المناعة الذاتية لدى المريضات.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة هامة في فهم الدور المناعي لبروتين Bcl2 في سرطان الثدي، إلا أنها تحتوي على بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة المستخدم قد يكون غير كافٍ للوصول إلى نتائج قابلة للتعميم على نطاق أوسع. ثانياً، لم يتم التطرق بشكل كافٍ إلى العوامل البيئية والوراثية التي قد تؤثر على مستويات Bcl2 والمناعة الذاتية. ثالثاً، كان من الممكن استخدام تقنيات تحليلية أكثر تقدمًا لتحليل البيانات بشكل أعمق. على الرغم من هذه النقاط، فإن الدراسة تقدم رؤى قيمة حول دور Bcl2 في سرطان الثدي وتفتح المجال لمزيد من الأبحاث في هذا المجال.
Questions related to the research
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ما هو الهدف الرئيسي من هذه الدراسة؟
الهدف الرئيسي هو دراسة الدور المناعي لبروتين Bcl2 في حدوث النكس لدى مريضات سرطان الثدي السوريات بعد المعالجة.
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ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟
النتائج الرئيسية هي أن مستويات Bcl2 المصلي كانت مرتفعة لدى المريضات مقارنة بالمجموعة الشاهدة، وأن المستويات العالية من Bcl2 تترافق مع زيادة احتمالية النكس وانخفاض في عيارات الأضداد المناعية الذاتية.
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ما هي التوصيات التي قدمتها الدراسة؟
توصي الدراسة ببحث دور الأضداد المناعية باستخدام طيف أوسع من الأضداد، واستخدام مقايسة Bcl2 المصلي كمؤشر على النكس، وإجراء دراسات أوسع لتحديد أهمية Bcl2 في الممارسة السريرية.
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ما هي العوامل التي لم يتم التطرق إليها بشكل كافٍ في الدراسة؟
لم يتم التطرق بشكل كافٍ إلى العوامل البيئية والوراثية التي قد تؤثر على مستويات Bcl2 والمناعة الذاتية.
References used
IARC: international Agency for Research on cancer: World cancer Report 2012 Breast cancer Estimated Incidence
rate research
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Background: people with cancer experience great changes in their life as a result of disease, treatment and disease prognosis which affect their quality of life .with the goal of investigating breast cancer patient's quality of life during chemother
apy in Tishreen hospital in Latakia..
Methods: 60 patients were invited to complete the European organization of research and treatment quality of life questionnaire version 3 and breast cancer quality of life module during their early stage of chemotherapy.
Results : the results show that the (73.3%) were under the age of fifty and half of them reported total health status score under (50) which reflects low quality of life in addition to impaired psychological ,social, cognitive and role functioning. Also more than 67% of patient suffered from chemotherapy- related side effects as nausea and vomiting, dyspnea, loss of appetite, insomnia, and fatigue. In addition to variance in quality of life scores according to age, marital status, occupation and level of education without changing of it by educational level. In addition to that the majority of patient had impaired sexual function and upset of hair loss and arm symptoms but with positive and optimistic future.
perspective. No significant differences in quality of life scores were found between urban and rural patients. Conclusion. Health care provider should assess routinely cancer patient quality of life during treatment to ascertain of providing appropriate care with supportive services for all patients
Aim: to assess the expression ofcathepsin B(ctsB; an important protease) in human
breast cancer and correlate that with the tumor grade.
Materials and Methods:Serial sections were obtained from 23 formalin-fixed paraffin
embedded breast cancer tis
sue specimens which were collected from Alasad University
Hospital and a pathological laboratory in Lattakia - Syria. Tissues were stained for
cathepsin B using immunohistochemistry. Tonsil tissues were also included as a positive
control.
Results:Positive cytoplasmic staining of CtsB was observed in both follicular
macrophages and endothelial cells in tonsil sections. In breast cancer tissues, tumor cells,
endothelial cells and stroma stained positive for CtsB. The presence of CtsB in blood
endothelium significantly correlated with the tumor grade (p=0.049).
Conclusion: These results supported the important role of cathepsin B in tumor
progression, particularly in angiogenesis. Future studies should investigate the regulating
mechanisms of cathepsin activities within the tumor environment, and that can be
considered as new tagets for cancer treatment.
This study aimed to assessing the relationship between locus of control and
depression among breast cancer patients. The study was carried out in the chemical and
radiational treatment center in Tishreen University Hospital – Latakia, Data collecte
d
from15/12/2015 to 15/2/2016.The sample comprised of 100 breast cancer patients. Three
tools was been used, the first tool (Demographic and Clinical Data Sheet) was been filling
by the researcher, then all patients which participated in the study was asked to answer on
the second tool (Rotter's Locus of control Scale) and the third tool (Beck Inventory Scale
II). This study found that there was significant statistical relation between locus of
controltype and depression degree among breast cancer patients, more than half of breast
cancer patients was had depression, and was had external locus of control. So it is
recommended study theeffect of training program to modify locus of control type on the
incidence average of depression among breast cancer patients.
A retrospective study included 25 cases with inflammatory breast cancer. The patients were admitted to AL-Assad University Hospital, Lattakia, Syria (average age 55, and range 49-61 years old). The most common clinical signs and symptoms were: erythe
ma 100%, edema 100%, enlarged axillary nodes 100%, Nipple flattened/inverted 96%, warm Breast 92%, Ridges/thickening of breast 84%, Peau d’orange 88%, painful/tender Breast 88%, and Mass 80%. Mammography findings were: an increase in skin thickness 100%, an increased tissue density in the involved breast 100%, and an asymmetric widening of the sub-cutaneous lymphatic vessels 33.33%. 80% of cases were diagnosed as stage IV. All patients received primary neoadjuvant chemotherapy for three cycles. After that a modified radical breast mastectomy and axillary lymph nodes dissection were performed for all patients. The wound edges were closed primarily after dissecting the skin in 76%, for 4 patients 16% a split-thickness skin grafts were performed, and for 2 patients 8% a Latissimus dorsi pedicled myocutaneous flap was performed.
In spite of all the advances in health care and medical technology,
provision of quality health care to cancer patients remains one of the
major challenges that health care professionals have to face in the
next years.
this study was conducted to
assess the effect of nursing care on
breast cancer patients quality of life at homes.
by using quazi-experimental design 80 breast cancer patients were
selected (40 experimental group ,40 control group) receiving
chemotherapy recently. Experimental group patients received
supportive psycho-educational interventions consisted of education,
progressive muscle relaxation technique with four supportive range
of motion exercises in addition to emotional support for three
months. While control group patients received routine nursing care
in hospital. The results were assessed for both groups by using
European organization for cancer research and treatment quality of
life questionnaire (EOCRT-QLQ C30) and breast cancer module.
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