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Register a new userComparative study between the rK39 dipstick test and the direct agglutination test for the diagnosis of visceral leishmaniasis in South of Syria
دراسة مقارنة بين اختباري شرائح المستضد المؤشّب rK39 و اختبار التراص المباشر DAT في الكشف عن داء الليشمانية الحشوي في جنوب سورية
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حاولنا من خلال هذه الدراسة المقارنة بين حساسية و نوعية اختبار شرائح rK39 و اختبار التـراص المباشر في تقصي وجود داء الليشمانية الحشوي في بعض القرى الموبوءة في جنوب سـورية، و ذلـك لاعتماد الاختبار الأفضل و الأسهل في الدراسات الوبائية كمؤشر لتقصي وجود هذا الداء ليس فقـط لـدى الأشخاص العرضيين (يبدون أعراضاً مرضية) و إنما لدى الأشخاص اللاعرضيين (لا يبدون أي عـرض مرضي) و المشكوك بهم عن طريق الكشف عن وجود الأضداد النوعية في مصولهم ليصار إلى معـالجتهم بشكل سريع و مبكر.
In the present study, we tried to compare the sensitivity and the specificity of the rK39 strips and DAT, to serodiagnose the visceral leishmaniasis disease in some endemic villages in south of Syria, in order to apply the best and the easy test in the epidemiological studies, for serodiagnosis this disease not only in symptomatic patients but also in asymptomatic and suspected cases in order to treat them early and rapidly.
References used
Hyams, K. C., Hanson, K., Wignall, F. S., Escamilla, J., and Oldfield, EC. (1995). III, The impact of infectious diseases in the health of U.S. troops deployed to persion Gulf during operations desert shield and desert strom. Clin. Infect. Dis. 20, 1497-1504
Sacks, D. L., Kenney, R. T., Kreutzer, R. D., Jaffe, C. L., Gupta, A. K., Sharma, M. C. Sinha, S. P., Neva, F. A., and Saron, R. (1995). Indian kalaazar caused by Leishmania tropica. Lancet, 345, 959-961
World health organization, WHO, (1996). Manual on visceral leishmaniasis control. WHO/Leish/ 96, 40
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The diagnosis of visceral leishmaniasis (VL) remains problematic for
physicians in Syria, because the appearance of this disease is new and its
clinical criteria are similar to Malaria, Tuberculosis, and Toxoplasmosis
symptoms. For this reason, we
used the specific antigen (rK39) of
Leishmania donovani complex, in order to certify the appearance of
visceral leishmaniasis in some patients. Then we followed the infected
cases with VL during treatment (15 days) and after treatment (10 days)
with Glucantime®. We noted an improvement in clinical criteria and a
significant decrease in the parasite numbers as well as in the specific L.
donovani antibodies.
According to the high specificity and sensitivity of ELISA test, we tried in
this preliminary study, to certify the usefulness of ELISA test in the detection of
specific antibodies (IgG) to cutaneous leishmaniasis(CL) in SYRIA, in order to
certify
the diagnosis of this disease by using the classic methods (observation
microscopic – culture).
There are no sufficient studies about the prevalence of Toxoplasmosis in Syrian
females, so our aim in this paper were 1) Screening study of Toxoplasmosis antibodies among Arab
International University female students in Syria, 2) determination of
positive percentage to spread the
disease, 3) set up a health educational program for prevention means of sero-negative cases.
The eddies at the Egyptian and the Middle East coasts are generated by the instability of the surface circulation (AW: Atlantic Water). For describing these eddies, a lot of satellite images (SST: Sea Surface Temperature) have been treated and analyz
ed at the Levantine sub-basin. This study inferred that there is an approchement in the eddies´ trajectory in both south west and south east of the Levantine sub-basin, where most eddies tend to separate from AW towards off sea. While eddies in the south east of the Levantine develop faster than that in the south west.
Cutaneous leishmaniasis is still one of the most important health
problems in Syria which witnessed increasing the numbers of
cutnaneous leishmaniasis reported, especially during the crisis ,Also
the direct microscopic examination of Giemsa-stained scrapings of
lesions is still a suitable method for diagnosis of cutaneous
leishmaniasis due to the low cost, ease of performance, speed, and
lack of a need for sophisticated laboratory equipment.
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