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Association skin tags and carbohydrate and lipids metabolism in outpatients at AL-Assad Hospital

دراسة العلاقة بين الزنمات واستقلاب السكر والشحوم عند مراجعي مشفى الأسد الجامعي

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 Publication date 2014
and research's language is العربية
 Created by Shamra Editor




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Skin tags are common benign skin tumors usually occurring on the neck and major flexors of older people. Objective: To investigate and compare the prevalence of diabetes and disorders of triglycerides, cholesterol, LDL, and HDL levels in patients with skin tags and a control group. A case-control study was conducted in individuals between (25-70) years old, comparing cases (n=107) and age-, sex-matched controls (n=97) without skin tag. Cases and controls were recruited from patients consecutively seen at the outpatient dermatology clinic at Al-Assad University Hospital in Lattakia. All patients underwent standard laboratory tests of fasting blood sugar , triglycerides , cholesterol , LDL , and HDL levels. Results: Patients with skin tags had higher frequency of diabetes and higher levels of triglycerides , cholesterol , and LDL than the control group (P <=0.0001) and lower levels of HDL in patients with skin tags than the control group (P<=0.001). A positive correlation was found between the existing of skin tags and high BMI comparing with the control group (P<=0.0001). According to our results, skin tags might be a useful clinical sign that could alert clinicians to screen patients with skin tags for abnormal lipids, type 2 diabetes mellitus, and cardiovascular disease, and guide patients with skin tags to modify their life style, avoiding risk factors and making clinical laboratory check-up periodically


Artificial intelligence review:
Research summary
تدرس هذه الورقة العلاقة بين الزنمات الجلدية واستقلاب السكر والشحوم عند مراجعي مشفى الأسد الجامعي. الزنمات الجلدية هي أورام جلدية سليمة شائعة تحدث عادة على العنق واللثنيات الرئيسة عند البالغين. الهدف من الدراسة هو تحري ومقارنة معدل انتشار الداء السكري واضطراب شحوم الدم والكوليسترول وقيم LDL وHDL عند مرضى الزنمات ومجموعة الشاهد. أجريت دراسة مقارنة (حالة - شاهد) على 107 حالة لديهم زنمات و97 فرداً من مجموعة الشاهد. خضع كل المرضى لمعيار القيم المخبرية لسكر الدم على الريق والشحوم الثلاثية والكوليسترول وLDL وHDL. أظهرت النتائج أن مرضى الزنمات لديهم تواتر أعلى لحدوث الداء السكري وارتفاع في شحوم الدم والكوليسترول وLDL وانخفاض في HDL مقارنة بمجموعة الشاهد. كما وجد ارتباط إيجابي بين وجود الزنمات وارتفاع مشعر كتلة الجسم. تشير النتائج إلى أن الزنمات الجلدية قد تكون علامة سريرية مفيدة يمكن أن تنبه الأطباء لتحري اضطراب شحوم الدم والداء السكري نمط 2 وحدوث الداء القلبي الوعائي عند مرضى الزنمات، وتوجيههم لتعديل نمط حياتهم وإجراء الفحوص الدورية.
Critical review
دراسة نقدية: تعد هذه الدراسة مهمة لأنها تسلط الضوء على العلاقة بين الزنمات الجلدية وبعض الأمراض الاستقلابية والقلبية الوعائية. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، العينة المستخدمة في الدراسة قد تكون غير كافية لتعميم النتائج على جميع السكان. ثانياً، لم يتم التطرق إلى العوامل الوراثية والبيئية التي قد تؤثر على النتائج. ثالثاً، كان من الأفضل استخدام طرق تحليلية أكثر تعقيداً لفهم العلاقة بين الزنمات والعوامل الأخرى بشكل أعمق. على الرغم من هذه النقاط، فإن الدراسة تقدم معلومات قيمة يمكن أن تكون مفيدة للأطباء والممارسين الصحيين.
Questions related to the research
  1. ما هي الزنمات الجلدية؟

    الزنمات الجلدية هي أورام جلدية سليمة شائعة تحدث عادة على العنق واللثنيات الرئيسة عند البالغين، وهي تتراوح في الحجم واللون.

  2. ما هو الهدف من الدراسة؟

    الهدف من الدراسة هو تحري ومقارنة معدل انتشار الداء السكري واضطراب شحوم الدم والكوليسترول وقيم LDL وHDL عند مرضى الزنمات ومجموعة الشاهد.

  3. ما هي النتائج الرئيسية للدراسة؟

    أظهرت النتائج أن مرضى الزنمات لديهم تواتر أعلى لحدوث الداء السكري وارتفاع في شحوم الدم والكوليسترول وLDL وانخفاض في HDL مقارنة بمجموعة الشاهد.

  4. ما هي التوصيات التي تقدمها الدراسة؟

    توصي الدراسة بأن الزنمات الجلدية قد تكون علامة سريرية مفيدة يمكن أن تنبه الأطباء لتحري اضطراب شحوم الدم والداء السكري نمط 2 وحدوث الداء القلبي الوعائي عند مرضى الزنمات، وتوجيههم لتعديل نمط حياتهم وإجراء الفحوص الدورية.


References used
Demir S, et al: Acrochordon and impaired carbohydrate metabolism. Acta Diabetol 2002;39:57
Banik R, Lubach D. Skin tags: localization and frequencies according to sex and age. Dermatologica.4111;174:180-3
Habif: Clinical Dermatology, 4th ed.Copyright © 2004 Mosby, Inc.p456
Kahana M, Grossman E, Feinstein A, et al. Skin tags: a cutaneous marker for diabetes mellitus. Acta Derm Venereol. 4111;67:175-7
Goodheart HP. Surgical pearl: a rapid technique for destroying small skin tags and filiform warts. Dermatol Online J 2003;9:34
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