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Epidemiology of Visceral leishmaniasis in Al- Assad University Hospital ,Latakia between 2010 and 2014

وبائيات الليشمانيا الحشوية في مشفى الأسد الجامعي في اللاذقية بين عامي 2010-2014

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 Publication date 2018
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Introduction 7 Visceral Leishmaniasis( VL )is characterized by a spectrum of clinical features, with high cure rates in early diagnosis. Objective: the objective is to describe the clinical and epidemiological features and laboratory variables of children with visceral leishmaniasis ,And to define the importance of a positive direct investigation of the parasite in Bone marrow in the diagnosis of disease . Patients and Methods : It was a case series study of )52( cases of Visceral Leishmaniasis which were hospitalized between June-20 31and June-2014 in Al -Assad University Hospital ,Latakia Results 52 7 7 children were included in this study .Majority of the patients (92%) presented with fever ,common findings in physical examination were(100%) Pallor and (97%) splenomegaly The direct investigation of parasite in Bone marrow was positive in )%55( of cases .


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Research summary
تتناول هذه الدراسة وبائيات داء الليشمانيا الحشوية في مشفى الأسد الجامعي في اللاذقية بين عامي 2010 و2014، حيث تم تحليل 25 حالة لأطفال مصابين بهذا المرض. يهدف البحث إلى وصف أهم الموجودات السريرية والوبائية والمتغيرات المخبرية لهؤلاء الأطفال، وتحديد نسبة إيجابية التحري المباشر للطفيلي في نقي العظم كوسيلة تشخيصية. أظهرت النتائج أن 92% من الأطفال قدموا بشكاية الترفع الحروري، و100% منهم كانوا يعانون من الشحوب، و97% من الضخامة الطحالية. كان التحري المباشر للطفيلي في نقي العظم إيجابيًا في 88% من الحالات. تم علاج المرضى باستخدام مركبات الإثتموان الخماسية والأمفوتريسين B، وكانت نسب الشفاء مرتفعة، حيث شُفي 88% من الحالات، وسجلت حالة وفاة واحدة فقط. توصي الدراسة بأهمية التشخيص المبكر والمعالجة المناسبة لداء الليشمانيا الحشوية، واعتماد الوسائل التشخيصية المخبرية غير الراضة، وتطبيق إجراءات الصحة العامة وصحة البيئة لتقليل عدد الإصابات السنوية.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة في تسليط الضوء على وبائيات داء الليشمانيا الحشوية في منطقة محددة من سوريا، وتقديم بيانات قيمة حول الأعراض السريرية والاستجابة للعلاج. ومع ذلك، يمكن انتقاد الدراسة من حيث حجم العينة الصغير الذي قد لا يعكس الصورة الكاملة للمرض في المنطقة. كما أن الاعتماد على بزل نقي العظم كوسيلة تشخيصية رئيسية قد يكون غير كافٍ في بعض الحالات، وكان من الممكن استخدام تقنيات تشخيصية إضافية لزيادة دقة النتائج. بالإضافة إلى ذلك، لم تتناول الدراسة بشكل كافٍ العوامل البيئية والاجتماعية التي قد تسهم في انتشار المرض، مما يحد من شمولية النتائج.
Questions related to the research
  1. ما هي الأعراض السريرية الأكثر شيوعًا لداء الليشمانيا الحشوية لدى الأطفال في هذه الدراسة؟

    الأعراض السريرية الأكثر شيوعًا كانت الترفع الحروري بنسبة 92%، الشحوب بنسبة 100%، والضخامة الطحالية بنسبة 97%.

  2. ما هي نسبة إيجابية التحري المباشر للطفيلي في نقي العظم في تشخيص داء الليشمانيا الحشوية؟

    كانت نسبة إيجابية التحري المباشر للطفيلي في نقي العظم 88%.

  3. ما هي الأدوية المستخدمة في علاج داء الليشمانيا الحشوية في هذه الدراسة؟

    تم استخدام مركبات الإثتموان الخماسية والأمفوتريسين B في علاج داء الليشمانيا الحشوية.

  4. ما هي التوصيات التي خرجت بها الدراسة لتحسين تشخيص ومعالجة داء الليشمانيا الحشوية؟

    توصي الدراسة بالتشخيص المبكر والمعالجة المناسبة لداء الليشمانيا، واعتماد الوسائل التشخيصية المخبرية غير الراضة، وتطبيق إجراءات الصحة العامة وصحة البيئة لتقليل عدد الإصابات السنوية.


References used
MÁRCIA J. A .QUEIROZ ,JOÃO G. B .ALVES ,JAILSON B .CORREIA . Visceral leishmaniasis 7clinical and epidemiological features of children in an endemic area .Jornal de Pediatria - Vol. 80, Nº2, 2004:142-146
Ebru ARIK YILMAZ ,Gönül TANIR ,Nilden TUYGUN ,Aysegul TAYLAN ÖZKAN Visceral Leishmaniasis in 13 Pediatric Patients in Turkey: Treatment Experience .Türkiye Parazitoloji Dergisi 33 (4): 2009,259 – 262
PHILIPPE DESJEUX , JEAN-PIERRE DEDET .Actualités sur le traitement de la leishmaniose viscérale .JNI, 8-10 Juin ,5112 Nice, France
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