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Register a new userProduction of Nanobodies directed against insulin-like growth factor-1 for diagnostic and therapeutic purposes
إنتاج أضداد نانوية موجهة ضد العامل المحفز للنمو شبيه الأنسولين IGF-1 الأغراض تشخيصية وعلاجية
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Damascus University رسالة ماجستير
Publication date
2014
fields
Agricultural Engineering
and research's language is
English
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يعد عامل النمو شبيه الأنسولين من الهرمونات الهامة صغيرة الحجم ( 70 حمض أميني ) في مجموعة الغدد الصماء . ينتج هذا العامل من الكبد تحت تاثير هرمون النمو . لهذا العامل اهمية صيدلانية كبيرة حيث يعد مسؤولاً عن تنظيم النمو والتمايز في عدة أنماط خلوية .
Insulin-like growth factor is an important small-sized (70 amino acid) hormone in the endocrine group. This factor is produced by the liver under the influence of growth hormone. This factor is of great pharmaceutical importance as it is responsible for regulating growth and differentiation in several cell types.
References used
Barbas, C. F., 3rd. 1993 . Recent advances in phage display. cuee opin Biotechnol, 4: 526-530.
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The study aimed to identify the levels of IGF-1 growth factor in patients with non-insulin-dependent diabetes mellitus, where the levels of IGF-1 growth factor and its relationship with some important laboratory parameters such as (fasting blood gluc
ose, HbA1c, duration of diabetes) were evaluated. LDL-c, HDL-c, TG, atherosclerotic index) in patients with type 2 diabetes mellitus (Typ2DM).
This study aimed to
investigate the validity of measuring IGFBP-3 in the serum of
Syrian children with acute lymphoblastic leukemia (ALL) as
additional markers in diagnosis and follow-up of the disease.
We propose EASE, a simple diagnostic tool for Visual Question Answering (VQA) which quantifies the difficulty of an image, question sample. EASE is based on the pattern of answers provided by multiple annotators to a given question. In particular, it
considers two aspects of the answers: (i) their Entropy; (ii) their Semantic content. First, we prove the validity of our diagnostic to identify samples that are easy/hard for state-of-art VQA models. Second, we show that EASE can be successfully used to select the most-informative samples for training/fine-tuning. Crucially, only information that is readily available in any VQA dataset is used to compute its scores.
Women is the half of society, which born and grow the second half, so take-up the oppression on women men to take-up it on whole society , because the women is the whole society, so the freedom of women is the freedom of country and human, where the
thrall mother cannot born freedom child , and sick mother cannot born healthy body, and mind child, so we must be attention toward necessary care of women ,and create suitable climant ,which help her to egress from the crucible of blindness, and darkness toward the court of science , and light supply the suitable circumstance, which command her to developed herself , and subsequently to developed the whole society, so man must stop to uses the Violence against women, because these thing disrupt her capability to life, and to feel her dignity, and humanity, but if he did not belief in these thing ,so we must constraint him by all possible procedure ,or methods.
The main aim of this study is to analyze all cases of pericardial effusions - except post
cardiac procedures - who were admitted to surgical department in Al-Assad and Tichreen
University Hospital in the period between 2007-2016.
(63) cases of Per
icardial effusions were analyzed, (38) male and (25) female, their ages
were ranging between (17-67) years.
The most important two causes of pericardial effusions were renal failure (50.7%) and
Malignancies (34.9%). lung cancer was the leading cause of Malignancies accounting
17.4% of whole cases and 50% of Malignancies.
Pericardial window via left mini thoracotomy was the preferred procedure in our study.
68.2% of the patients under went this procedure, recurrent rate was 4.6%, and the amount
of recurrent pericardial effusion was minimal and didn’t need any management.
Pericardiocentesis was performed in 39.6% of our patients, recurrent rate was very high
80%, therefore it was abondend as a method of treatment and its role was considered only
in hemodynamically unstable patients or as a first step of preparation for pericardial window.
Pericardial window via subxyhoid under local anesthesia was performed in 11.11%;
recurrent rate was high 28.6%.We consider this approach only in patients who are not fit to
undergo other approaches or when the expected survival is very limited.
Pericardial window via thoracoscopic approach was performed in 15.8% of our patients;
recurrent rate was 10% with encouraging results. During performance of pericardial
window via minithoracotomy or thoracoscopically we were able to perform in (19) patients
many other diagnostic and therapeutic procedures such as pleurectomy, Biopsies from the
lungs, mediastinal tumors, and mediastinal lymph nodes as well.
The histopathological examination of the resected pericardial window and concurrent
procedures played an important diagnostic role in 23.8% of idiopathic pericardial
effusions.
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