Uric acid (UA) has a role in pathogenesis of several metabolic abnormalities including insulin resistance (IR) and their related disorders. The aim of this report is to review the available evidences that reveal the association between UA, IR and rel
ated disorders via both noninsulin and insulin-based IR indices.
METHODS: The published literature was surveyed using Google Scholar and PubMed entering the terms Obesity, UA, IR, Metabolic Syndrome (MetS), Gestational Diabetes (GDM), Polycystic Ovarian Syndrome (PCOS).
RESULTS: UA had substantial positive relationships with IR, as well as obesity, MetS, DM, GDM, and PCOS. Evidently UA with a role in oxidative stress, endothelial dysfunction and induction of inflammation may cause IR in totality, the major factor in development of MetS and related diseases. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), insulin based IR index, correlated positively with UA. Moreover, specifically triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-C), visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride to fasting glucose (TyG) index are noninsulin-based IR indices of positive correlations with UA. MetS score for IR (MetS-IR), a non-insulin based IR index, had significantly proportional correlations with MetS components as well as UA level. UA to HDL-cholesterol ratio (UHR) was a pronounced statistical predictor of MetS and diabetes control. UA positively associated with hyperinsulinemia and IR in prediabetes.
CONCLUSION: Succinctly UA can be an emerging biochemistry marker of predictive role in IR, MetS and related anomalies. More hyperuricemia related studies are warranted to be oriented from being correlational to mechanistic
The study aimed to identify the levels of IGF-1 growth factor in patients with non-insulin-dependent diabetes mellitus, where the levels of IGF-1 growth factor and its relationship with some important laboratory parameters such as (fasting blood gluc
ose, HbA1c, duration of diabetes) were evaluated. LDL-c, HDL-c, TG, atherosclerotic index) in patients with type 2 diabetes mellitus (Typ2DM).
تعرف الجمعية الأميركية السكري بأنه مجموعة من الاضطرابات الاستقلابية تتميز بفرط غلوكوز الدم نتيجة نقص في افراز الانسولين او مقاومة عمله او كليهما معا
Insulin-like growth factor is an important small-sized (70 amino acid) hormone in the endocrine group. This factor is produced by the liver under the influence of growth hormone. This factor is of great pharmaceutical importance as it is responsible for regulating growth and differentiation in several cell types.
