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Register a new userCorrelation of Insulin like growth factor-1( IGF-1) with some clinical Criteria among patients with diabetes mellitus
علاقة عامل نمو الشبيه بالإنسولين-1 ببعض المعايير السريرية لدى مرضى داء السكري
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Aِl-Baath University رسالة ماجستير
Publication date
2018
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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هدفت الدراسة إلى التعرف على مستويات عامل النمو IGF-1 عند مرضى الداء السكري غير المعتمد على الإنسولين , حيث تم تقييم مستويات عامل النمو IGF-1 وعلاقته مع بعض المعالم المخبرية الهامة مثل ( غلوكوز الدم الصيامي , الخضاب السكري HbA1c , مدة الإصابة بالداء السكري . LDL-c , HDL-c , TG , المنسب العصيدي ) لدى مرضى الداء السكري النمط الثاني Typ2DM
The study aimed to identify the levels of IGF-1 growth factor in patients with non-insulin-dependent diabetes mellitus, where the levels of IGF-1 growth factor and its relationship with some important laboratory parameters such as (fasting blood glucose, HbA1c, duration of diabetes) were evaluated. LDL-c, HDL-c, TG, atherosclerotic index) in patients with type 2 diabetes mellitus (Typ2DM).
References used
رويحة أمين 1973 - داء السكري أسبابه , اعراضه , طرق مكافحته . الطبعة الأولى منشورات دار القلم
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Insulin-like growth factor is an important small-sized (70 amino acid) hormone in the endocrine group. This factor is produced by the liver under the influence of growth hormone. This factor is of great pharmaceutical importance as it is responsible for regulating growth and differentiation in several cell types.
Background: Diabetes mellitus type2 (T2DM) and thyroid dysfunction (TD) are the
two most common endocrine disorders in clinical practice. The unrecognized TD may
adversely affect the metabolic control and add more risk to an already predisposing
s
cenario for cardiovascular diseases. The objective of this study was to investigate the
prevalence of TD in patients with type2 diabetes mellitus.
Objective: To determine the prevalence and patterns of thyroid dysfunction in
patients with type2 diabetes mellitus.
Material and methods: Study included total 362 subjects (204 type2 diabetic patients
and 158 healthy non diabetic subjects). Agroup of type2 diabetic patients and control group
were evaluated for thyroid dysfunction by testing TSH and FT4 when TSH was abnormal.
The correlation of prevalence of thyroid disorder with gender distribution, age distribution,
duration of diabetes, BMI, treatment, fasting plasma glucose (FPG), serum triglyceride and
serum cholesterol was then done in diabetic patients. The observations and interpretations
were recorded and results obtained were statistically analyzed.
Results: The prevalence of thyroid dysfunction among type2 diabetic patients was
found to be 13,2%. In the control group, the prevalence of thyroid dysfunction was 6,3%.
There was a significant difference between diabetics and control subjects p= 0,031.The
most frequently TD in type2 diabetic patients was subclinical hypothyroidism (8,3%).
Thyroid dysfunction was significantly correlated with gender (women > man), age < 60
years, FPG > 130mg/dl, TG > 150mg/dl and insulin treatment in type2 diabetic patients.
Conclusion: Screening of thyroid dysfunction shoud be done in all Type2 diabetic
patients.
Type 2 Diabetes mellitus T2DM has been suggested to be the most common
metabolic disorder associated with magnesium deficiency which has many adverse
outcomes. The aim of this study was to evaluate plasma Mg in 126 T2DM patients
recruited from Dia
betes Centre in Lattakia, compare them to 70 healthy individuals, and
assess the correlation between plasma Mg and HbA1c as a glycemic control biomarker.
Magnesium was measured using xylidyl blue colorimetric method. HbA1c was measured
using ion-exchange resin separation. The SPSS 19.0 software was used for statistical
analysis. Mean plasma Mg concentrations of the diabetics was significantly lower than
controls (P=0.0001). Plasma magnesium was negatively correlated with HbA1c (r=-0.5,
P=0.0002). Plasma magnesium was below the normal reference range (1.9-2.5 mg/dL) in
47.6% of diabetics and 28.6% of controls. In conclusion, it is important to monitor Mg
levels in both T2DM patients and non-diabetics and take procedures to correct
hypomagnesaemia states.
The research aims to identify the level of psychological stress in
patients with diabetes type II,as well as to identify differences in
the differences between the mean responses of patients with
diabetes type II on a scale of sources of psycholog
ical stress due to the variables(sex, years of disease, marital status).Search sample Included(272)male and female patients. they were applied to a scale consisting of(56)statement divided into six levels which are (emotional stress, pressures resulting from diabetes,pressures resulting from friends and colleagues, physical pressures,family and social pressure, customs and traditions pressures).Pilot sample consisted of (32)patients, Reliability was established by Cronbach – Alpha Reliability at lest (0.71), and (0.718)by Test – Retest.
Results showed that the level of psychological stress was
moderately.The findings also revealed the presence of statistically
significant differences depending on the gender variable for the
benefit of female patients and the presence of statically significant differences depending on the variable of marital status for the benefit of the married patients,as well as the presence of statically significant differences depending on the variable of number of years of the disease for the benefit of high number of years of disease.
This study aimed to
investigate the validity of measuring IGFBP-3 in the serum of
Syrian children with acute lymphoblastic leukemia (ALL) as
additional markers in diagnosis and follow-up of the disease.
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