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Register a new userThe role of insulin like growth factor binding protein 3 (IGFBP-3) in treatment monitoring of Syrian children with Acute lymphoblastic leukemia
دور البروتين الرابط لعامل النمو الشبيه بالأنسولين 3 في متابعة المعالجة لدى أطفال سوريين مصابين بابيضاض الدم اللمفاوي الحاد
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Aِl-Baath University ورقة بحثية
Publication date
2018
fields
Pharmacy
and research's language is
العربية
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Shamra Editor
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تهدف هذه الدراسة إلى تقصي أهمية مقايسة المعلم IGFBP-3 البروتين الرابط لعامل النمو الشبيه بالأنسولين 3 لدى أطفال سوريين مصابين بابيضاض دم لمفاوي حاد لاستخدامه كمؤشر إضافي في تشخيص المرض و متابعة تطوره.
This study aimed to investigate the validity of measuring IGFBP-3 in the serum of Syrian children with acute lymphoblastic leukemia (ALL) as additional markers in diagnosis and follow-up of the disease.
References used
Bethesda, SEER Cancer Statistic Review, National Cancer Institute. 1973، 467، 2000
R. Wäsch, W.D., M. Lübbert, Hematological Neoplasia, in Concise Manual of Hematology and Oncology, M.E. D.P.Berger, H.Henb, R. Mertelsmann ,Editor, Springer: Springer-Verlag، 400-529،Berlin Heidelberg 2008
Corrigan JJ, F.S., Guidelines for pediatric cancer centers. Pediatrics. 113:182-183، 2004
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Chemotherapy causes neutropenia and increase susceptibility to infections. Morbidity and mortality due to infections remain serious problem in children with cancer. Decreased serum levels of Mannose-binding lectin ( MBL) may represent a risk factor f
or infections in children with acute lymphoblastic leukemia receiving chemotherapy.
The aim of this study was to determine whether low MBL levels is associated with increased risk of infections in Syrian children with acute lymphoblastic leukemia.
The study has been done at Children University Hospital in Damascus between 2013-2014. This study included 37 children diagnosed with acute lymphoblastic leukemia (ALL) who were candidates for chemotherapy, and the infections were identified depending on patients files. The levels of Mannose-Binding Lectin (MBL) was determined by Enzyme Linked Immuno Sorbent Assay (ELISA).
The result was that MBL serum levels are higher in patients who did not develop infections compared to patients who developed infections, and all patients with low MBL levels developed infections in contrast to patients with normal MBL serum levels.
In contrast to adaptive immunity and to certain components of innate immunity, only little is known on the influence of the complement system on cancer suppression and promotion . The lectin pathway of complement activation is an important part of in
nate immunity. It is mainly involved in opsonisation and lysis of pathogens and in recruitment of inflammatory cells.
Our study aimed to assess the relationship between MASP-2 serum levels before and after chemotherapy in Syrian children with acute lymphoblastic leukemia, aiming to find a relation, which serve in early forecast of patients response to chemotherapy, where the study has been done at Children University Hospital in damascus between 2013-2014. This study included 37 children diagnosed with acute lymphoblastic leukemia (ALL). The levels of Mannose-Binding Lectin-associated Serine Protease-2 (MASP-2) were determined by Enzyme Linked Immuno Sorbent Assay (ELISA).
The result was that serum levels of MASP-2 was strongly reduced after chemotherapy in children with acute lymphoblastic leukemia, and a strong correlation between serum marker levels before and after chemotherapy was found.
Our study aimed to evaluating significance of survivin as a
prognostic marker of relapse in children with acute lymphoblastic
leukemia. The study included 46 child (30 males, 16 females): 24
child with ALL at 35 day from BFM 95 Protocol and 22 rel
apse
child with ALL.
The study aimed to identify the levels of IGF-1 growth factor in patients with non-insulin-dependent diabetes mellitus, where the levels of IGF-1 growth factor and its relationship with some important laboratory parameters such as (fasting blood gluc
ose, HbA1c, duration of diabetes) were evaluated. LDL-c, HDL-c, TG, atherosclerotic index) in patients with type 2 diabetes mellitus (Typ2DM).
Relapse of acute lymphoblastic leukemia (ALL) in the central nervous system
(CNS) in adults is considered a poor prognostic feature. Few reports have analyzed this issue. The
objective of this study was to estimate the experience with CNS recurrence in adult patients with ALL,
then to choose the best therapy.
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