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Evaluation of Plasma Magnesium Levels and its Correlation with Glycemic Control in Type 2 Diabetes Mellitus Patients

العلاقة بين مستويات المغنزيوم البلازمية و ضبط سكر الدم عند مرضى الداء السكري من النمط الثاني

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 Publication date 2017
and research's language is العربية
 Created by Shamra Editor




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Type 2 Diabetes mellitus T2DM has been suggested to be the most common metabolic disorder associated with magnesium deficiency which has many adverse outcomes. The aim of this study was to evaluate plasma Mg in 126 T2DM patients recruited from Diabetes Centre in Lattakia, compare them to 70 healthy individuals, and assess the correlation between plasma Mg and HbA1c as a glycemic control biomarker. Magnesium was measured using xylidyl blue colorimetric method. HbA1c was measured using ion-exchange resin separation. The SPSS 19.0 software was used for statistical analysis. Mean plasma Mg concentrations of the diabetics was significantly lower than controls (P=0.0001). Plasma magnesium was negatively correlated with HbA1c (r=-0.5, P=0.0002). Plasma magnesium was below the normal reference range (1.9-2.5 mg/dL) in 47.6% of diabetics and 28.6% of controls. In conclusion, it is important to monitor Mg levels in both T2DM patients and non-diabetics and take procedures to correct hypomagnesaemia states.


Artificial intelligence review:
Research summary
تناولت الدراسة العلاقة بين مستويات المغنزيوم البلازمية وضبط سكر الدم عند مرضى الداء السكري من النمط الثاني (T2DM). شملت الدراسة 126 مريضاً من المراجعين لمركز السكري في مدينة اللاذقية، وقورنت نتائجهم بمجموعة من الأصحاء شملت 70 فرداً. تم قياس مستويات المغنزيوم باستخدام الطريقة اللونية Xylidyl Blue، وقياس HbA1c باستخدام الاستشراب المبادل للشوارد. أظهرت النتائج انخفاضاً ملحوظاً في تراكيز المغنزيوم البلازمية عند المرضى مقارنة بالأصحاء، وارتبطت المستويات المنخفضة للمغنزيوم بضبط سيء لمستويات السكر في الدم، مما يبرز أهمية مراقبة تراكيز المغنزيوم عند مرضى السكري النمط الثاني والأصحاء على حد سواء، واللجوء إلى المعاوضة الدوائية أو الغذائية عند حدوث العوز.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة هامة في فهم العلاقة بين مستويات المغنزيوم وضبط سكر الدم عند مرضى السكري من النمط الثاني. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الممكن أن تكون العينة أكبر وأكثر تنوعاً لتشمل مناطق جغرافية مختلفة، مما قد يعزز من دقة النتائج. ثانياً، لم تتناول الدراسة بشكل كافٍ العوامل الغذائية والبيئية التي قد تؤثر على مستويات المغنزيوم، مثل نوعية الغذاء والنشاط البدني. ثالثاً، لم يتم التطرق إلى تأثير الأدوية الأخرى التي قد يتناولها المرضى على مستويات المغنزيوم. على الرغم من هذه النقاط، فإن الدراسة تقدم معلومات قيمة تستحق المتابعة في أبحاث مستقبلية.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تقييم مستويات المغنزيوم البلازمية عند مرضى السكري من النمط الثاني ودراسة علاقتها بضبط سكر الدم ممثلاً بقيم HbA1c.

  2. ما هي الطريقة المستخدمة لقياس مستويات المغنزيوم في الدراسة؟

    تم قياس مستويات المغنزيوم باستخدام الطريقة اللونية Xylidyl Blue.

  3. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    أظهرت الدراسة انخفاضاً ملحوظاً في تراكيز المغنزيوم البلازمية عند مرضى السكري من النمط الثاني مقارنة بالأصحاء، وارتبطت المستويات المنخفضة للمغنزيوم بضبط سيء لمستويات السكر في الدم.

  4. ما هي التوصيات التي قدمتها الدراسة بناءً على النتائج؟

    أوصت الدراسة بضرورة مراقبة تراكيز المغنزيوم بشكل دوري عند مرضى السكري النمط الثاني والأصحاء، واللجوء إلى المعاوضة الدوائية أو الغذائية عند حدوث العوز.


References used
FEINGLOS, M.N.; BETHEL, M.A. Type 2 Diabetes Mellitus: An Evidence- Based Approach to Practical Management. contemporary Endocrinology. 2008, Humana Press, 2008, XIII, 474
PEREIRA, M.A. Nutrition and Type 2 Diabetes: Etiology and Prevention. CRC Press, 2013, 105-150
SWAMINATHAN, R. Magnesium metabolism and its disorders. Clin Biochem Rev, 24 (2), 2003, 47-66
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