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Register a new userEvaluation of Plasma Magnesium Levels and its Correlation with Glycemic Control in Type 2 Diabetes Mellitus Patients
العلاقة بين مستويات المغنزيوم البلازمية و ضبط سكر الدم عند مرضى الداء السكري من النمط الثاني
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يعتبر الداء السكري من النمط الثاني (T2DM) أشيع الأمراض الاستقلابية التي تترافق مع عوز المغنزيوم. و نظراً للتأثيرات السلبية الناتجة عن هذا العوز فقد هدفت دراستنا إلى تقييم مستويات المغنزيوم عند مجموعة من مرضى T2DM شملت 126 مريضاً من المراجعين لمركز السكري في مدينة اللاذقية و مقارنتهم بمجموعة من الأصحاء شملت 70 فرداً، بالإضافة لدراسة علاقة المغنزيوم بالخضاب الغلوكوزي HbA1c كمشعر لضبط سكر الدم عند المرضى. تمت معايرة المغنزيوم بالطريقة اللونية Xylidyl Blue، و HbA1c بالاستشراب المبادل للشوارد، و عولجت النتائج إحصائياً باستخدام برنامج SPSS 19.0. و أظهرت النتائج انخفاض تراكيز المغنزيوم البلازمية عند المرضى مقارنة بـالأصحاء (P=0.0001)، و باعتماد المجال المرجعي للمغنزيوم البلازمي 1.9-2.5 ملغ/دل لوحظ عوز المغنزيوم عند 47.6% من المرضى و 28.6% من الأصحاء، كذلك لوحظ وجود ارتباط سلبي بين مستويات Mg و HbA1c عند المرضى (r=-0.5, P=0.0002)، أي ترافقت المستويات المنخفضة للمغنزيوم مع الضبط السيء لمستويات السكر الدموية. يبرز ذلك ضرورة مراقبة تراكيز المغنزيوم عند مرضى T2DM و عند الأصحاء و المعاوضة الدوائية أو الغذائية عند حدوث العوز.
Type 2 Diabetes mellitus T2DM has been suggested to be the most common metabolic disorder associated with magnesium deficiency which has many adverse outcomes. The aim of this study was to evaluate plasma Mg in 126 T2DM patients recruited from Diabetes Centre in Lattakia, compare them to 70 healthy individuals, and assess the correlation between plasma Mg and HbA1c as a glycemic control biomarker. Magnesium was measured using xylidyl blue colorimetric method. HbA1c was measured using ion-exchange resin separation. The SPSS 19.0 software was used for statistical analysis. Mean plasma Mg concentrations of the diabetics was significantly lower than controls (P=0.0001). Plasma magnesium was negatively correlated with HbA1c (r=-0.5, P=0.0002). Plasma magnesium was below the normal reference range (1.9-2.5 mg/dL) in 47.6% of diabetics and 28.6% of controls. In conclusion, it is important to monitor Mg levels in both T2DM patients and non-diabetics and take procedures to correct hypomagnesaemia states.
References used
FEINGLOS, M.N.; BETHEL, M.A. Type 2 Diabetes Mellitus: An Evidence- Based Approach to Practical Management. contemporary Endocrinology. 2008, Humana Press, 2008, XIII, 474
PEREIRA, M.A. Nutrition and Type 2 Diabetes: Etiology and Prevention. CRC Press, 2013, 105-150
SWAMINATHAN, R. Magnesium metabolism and its disorders. Clin Biochem Rev, 24 (2), 2003, 47-66
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two most common endocrine disorders in clinical practice. The unrecognized TD may
adversely affect the metabolic control and add more risk to an already predisposing
s
cenario for cardiovascular diseases. The objective of this study was to investigate the
prevalence of TD in patients with type2 diabetes mellitus.
Objective: To determine the prevalence and patterns of thyroid dysfunction in
patients with type2 diabetes mellitus.
Material and methods: Study included total 362 subjects (204 type2 diabetic patients
and 158 healthy non diabetic subjects). Agroup of type2 diabetic patients and control group
were evaluated for thyroid dysfunction by testing TSH and FT4 when TSH was abnormal.
The correlation of prevalence of thyroid disorder with gender distribution, age distribution,
duration of diabetes, BMI, treatment, fasting plasma glucose (FPG), serum triglyceride and
serum cholesterol was then done in diabetic patients. The observations and interpretations
were recorded and results obtained were statistically analyzed.
Results: The prevalence of thyroid dysfunction among type2 diabetic patients was
found to be 13,2%. In the control group, the prevalence of thyroid dysfunction was 6,3%.
There was a significant difference between diabetics and control subjects p= 0,031.The
most frequently TD in type2 diabetic patients was subclinical hypothyroidism (8,3%).
Thyroid dysfunction was significantly correlated with gender (women > man), age < 60
years, FPG > 130mg/dl, TG > 150mg/dl and insulin treatment in type2 diabetic patients.
Conclusion: Screening of thyroid dysfunction shoud be done in all Type2 diabetic
patients.
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To study the prevalence of the diabetic hand in a group of type 2 diabetics,
comparing to age- sex matched non-diabetics control group, and to investigate clinical features among
diabetics with or without the diabetic hand.
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