Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userStudy of the synthesis of some Indomethacin derivatives
دراسة اصطناع بعض مشتقات الإندوميتاسين
1081
0 13
0
(
0
)
Created by
Shamra Editor
Ask ChatGPT about the research
تم في هذا البحث اصطناع مشتقين للإندوميتاسين، حيث تم اصطناع الاستر الإيتيلي للإندوميتاسين بطريقة الأسترة المباشرة من خلال مفاعلة الإندوميتاسين مع الإيتانول ضمن شروط مختلفة من زمن و نسبة مولية و مذيبات مختلفة في وسط حمضي باستخدام حفازات حمضية متجانسة مثل حمض الكبريت و حمض ميتان سلفونيك و غير متجانسة مثل الأمبرليست- 15 ، ثم تم اصطناع هيدرازيد أسيد الإندوميتاسين من خلال مكاثفة الاستر السابق مع الهيدرازين المائي و درست الشروط الأفضل من زمن و نسبة مولية و مذيبات و درجات حرارة مختلفة بدون استخدام أي حفاز.
In this research two Indomethacin derivatives were synthesized, Indomethacin ethyl ester was synthesized by The Direct Esterification method by reacting indomethacin with ethanol within different conditions of time, molar ratios and solvents in acidic medium using homogeneous acid catalysts such as sulfuric acid and methane sulfuric acid and heterogeneous acid catalysts such as amberlyst- 15. Then indomethacin acid hydrazide was synthesized by condensing the previous ester with hydrazine hydrate and the best conditions were studied of time, molar ratios, solvents and different temperatures without using any catalyst.
References used
SHEN. T.Y., (1982) The Discovery of Indomethacin and the Proliferation of NSAIDs, Semfnars in Arthritts and Rheumarrsm, Vol. 12, No. 2, pp 89-93
BADIGER. J., Manjulatha. K., Girish.M., Sharif. A., and Purohit. M. G., (2009) Synthesis and biological evaluation of some N-substituted indoles, Arkivoc, Vol. 12, pp 217-231
VARDANYAN. R.S. and HRUBY. V.J., (2006) Synthesis of Essential Drugs. Elsevier, chapter 3, pp. 38-39
rate research
Read More
We have synthesized some new compounds from 2-Acetyl Fluorene\ Thiophene
2-carbaldehyde chalcone via condensation and cyclization reactions between the chalcone and each of thiourea and urea, hydroxylamine hydrochloride and hydrazine hydrate, these
reactions afford these compounds:
3-(2-fluorenyl)-5-(2-thienyl) pyrazoline(4), 3-(2-fluorenyl)-5-(2-thienyl) Isoxazoline(3), 4-(2-fluorenyl)-6-(2-thienyl) pyrimidinone-2 (2) and 4-(2-fluorenyl)-6-(2-thienyl) pyrimidine-2 tione (1). Also 3-(2-fluorenyl)-5-(2-thienyl) isoxazole (5), were prepared via bromination of chalcon and cyclization the later with hydroxylamine hydrochloride.
Identification and determination of compounds structurs were carried out by (IR,
1H-NMR, 13C-NMR, LC-MS) spectrum Analysis.
In this research, we have used eco-friendly method to prepare four derivatives of 1,2,4-triazole Esters by using the following general nucleophilic substitution reaction.
Quinaldine includes shifting hydrogenes which might be involved in
important reactions as the condensation and Mannich reactions.
Quinophtalone has been prepared through the reaction of quinaldine with
phtalyic anhydride in the presence of alumini
um chloride anhydrous
Imines derivatives have been prepared through the reaction of
Quinophtalone with hydroxideamine and phenyl hydrazine and then
diazotion anyhydride has been done to the resulting compounds.
The prepared compounds were characterized by ( H1NMR,IR, MS)
In this work the electrochemical behavior of Para-nitro aniline
and metoxy benzealdehyde was studied by cyclic voltammetric
method on glassy carbon electrode in alkaline medium . It was
found that the Para- nitro aniline needed five electrons to reduce to
the azo group.
Two ethers coumarin derivatives: 7-phenoxy -4-carboxylic
coumarin (B) and 7- (6,2-di-chloro) -4-carboxylic coumarin (C)
have been synthesized from the 7-hydroxy-4-methy coumarin
(A) as beginning compound and the copper complex [CuPPh3Cl]4
carried on the amberlyst-21 as the eco-friendly catalyst, these ethers
coumarin derivatives have an important biological properties may
be used in the treatment of breast cancer.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
