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Register a new userThe Reaction of some triazole derivatives with 1-halogen esters
دراسة تفاعل بعض مشتقات التريازول مع 1- هالوجين الاسترات
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Aِl-Baath University رسالة ماجستير
Publication date
2017
fields
Chemistry
and research's language is
العربية
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تم في هذا البحث استخدام طريقة صديقة للبيئة لاصطناع أربع مركبات جديدة من مشتقات -4,2,1 تريازول الاسترات وذلك من خلال تفاعل الاستبدال النوكليوفيلي العام .
In this research, we have used eco-friendly method to prepare four derivatives of 1,2,4-triazole Esters by using the following general nucleophilic substitution reaction.
References used
Pat.443763 (USA) . Process for cyanohydrin esters, 12-9-1978
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This research includes the manufacture of the following compounds: Synthesis of three compounds 1- Chlorine esters. 2- Synthesis of ester derivatives of Tiwalbola. 3- Synthesizing a derivative of Tiwalbola, which is Ethylene Tiwalbola. 4- Synthesis of ester derivatives of Ethylene Tiwalpola
In this research two Indomethacin derivatives were
synthesized, Indomethacin ethyl ester was synthesized by
The Direct Esterification method by reacting indomethacin
with ethanol within different conditions of time, molar
ratios and solvents in a
cidic medium using homogeneous
acid catalysts such as sulfuric acid and methane sulfuric
acid and heterogeneous acid catalysts such as amberlyst-
15. Then indomethacin acid hydrazide was synthesized by
condensing the previous ester with hydrazine hydrate and
the best conditions were studied of time, molar ratios,
solvents and different temperatures without using any
catalyst.
The 1,3-dipolar cycloaddition of the aryl azide and some its of derivatives with cyclohex-
2-en-1-one was studied theoretically using different methods of Density Functional
Theory (DFT): B3LYP, B3PW91, MPW1PBE, MPW1PW91 and M062X with the basic
s
et 6-31g(d). Most of the used levels of theories provide closed results qualitatively, and
the results of the level of theory M062X / 6-31g (d) show that these reactions in the gas
state are spontaneously to form two products, but all the reactions are very slow and one of
the products P1 is more spontaneous and faster than the other P2 , and when these
reactions were studied with different solvents, it is found that solvents to have no actual
effects on the rates of these reactions.
The results of the level of theory M062X / 6-31g (d) indicate that the Gibbs free energy of
the reactions for the substitutes of Aryl increases in negative values in order of 2,6-Cl, -4
NO2, 4-OCH3, 3-OCH3, 3-Cl, 2 -Cl, H-; i.e., the substitutes do not have a significant
effect on the spontaneity of reactions compared to the substitute-H. It was observed that
TS-P1 transition state energy for all substitutes was lower than TS-P2 transition state
energy.
Quinaldine includes shifting hydrogenes which might be involved in
important reactions as the condensation and Mannich reactions.
Quinophtalone has been prepared through the reaction of quinaldine with
phtalyic anhydride in the presence of alumini
um chloride anhydrous
Imines derivatives have been prepared through the reaction of
Quinophtalone with hydroxideamine and phenyl hydrazine and then
diazotion anyhydride has been done to the resulting compounds.
The prepared compounds were characterized by ( H1NMR,IR, MS)
Four Model Maillard reactions (MRs) have been carried out using Leucine
with each of the following Saccharides; aldohexose (glucose, Glc), ketohexose
(fructose, Fru), aldopentose (xylose, Xyl) and disaccharide (Lactose, Lac) at
100 °C and for 24hr
s. The pH changes with time were monitored during the
reactions at different initial reactant ratio. The products of the reactions
(MRPs) were then separated by absolute ethanol into low and high molecular
weight fractions (LMW & HMW). The four distinct Saccharides–Leucine
MRPs were studied by fluorescence and ultraviolet /visible spectrophotometer.
The results showed the tendency of Xyl–Leu MRPs to form brown polymers
with relatively high reaction rates compared to Fru, Glc and Lac -Leu MRPs
respectively. Further characterization of reducing power of the Saccharides –
Leu (MRPs) was performed and showed that different Saccharides –LeuHMW
(MRPs) had a higher reducing power than LMW ( MRPs).
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