Aseries of Schiff base and their derivative (fluorene) have been synthesized primary
amines was condensed with 2-acetyl fluorene in DMF (dimethyl formamide) in the
presence of conc. HCl acid as catalyst to yield the Schiff base (1). The Schiff base
(2,3)
and (4) were prepared from the reaction of Schiff base (1) with 2-hydroxy-5-methyl-1,3-
benzenedicarboxaldehyde and 2,5-dihydroxy benzaldehyde respectively. and The Schiff’s
base (4) was treated with monochloroacetyl choride to give 1- substituted-4(2-fluorenyl)-3-
chloro Azolidine-2-on (5).
We have synthesized some new compounds from 2-Acetyl Fluorene\ Thiophene
2-carbaldehyde chalcone via condensation and cyclization reactions between the chalcone and each of thiourea and urea, hydroxylamine hydrochloride and hydrazine hydrate, these
reactions afford these compounds:
3-(2-fluorenyl)-5-(2-thienyl) pyrazoline(4), 3-(2-fluorenyl)-5-(2-thienyl) Isoxazoline(3), 4-(2-fluorenyl)-6-(2-thienyl) pyrimidinone-2 (2) and 4-(2-fluorenyl)-6-(2-thienyl) pyrimidine-2 tione (1). Also 3-(2-fluorenyl)-5-(2-thienyl) isoxazole (5), were prepared via bromination of chalcon and cyclization the later with hydroxylamine hydrochloride.
Identification and determination of compounds structurs were carried out by (IR,
1H-NMR, 13C-NMR, LC-MS) spectrum Analysis.