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Register a new userSynthesis of som ethers coumarin via green method
اصطناع بعض الإيترات الكومارينية بطريقة صديقة للبيئة
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Chemistry
and research's language is
العربية
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Shamra Editor
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تم في هذا البحث اصطناع مشتقان من الايترات الكومارينية 7-فينوكسي -4- ميتيل مومارين و 7- (2,6-دي كلورو) فينوكسي-4- ميتيل كومارين انطلاقا من 7-هيدروكسي 4- ميتيل كومارين و هما مركبات يمتازان بخواص بيولوجية هامة حيث يمكن أن يكون لهما تطبيقات داوئية في معالجة سرطان الثدي.
Two ethers coumarin derivatives: 7-phenoxy -4-carboxylic coumarin (B) and 7- (6,2-di-chloro) -4-carboxylic coumarin (C) have been synthesized from the 7-hydroxy-4-methy coumarin (A) as beginning compound and the copper complex [CuPPh3Cl]4 carried on the amberlyst-21 as the eco-friendly catalyst, these ethers coumarin derivatives have an important biological properties may be used in the treatment of breast cancer.
References used
R. I. Al-Bayati1, A. A. Hussain Al-Amiery2 and Y. K. Al- Majedy, Design, synthesis and bioassay of novel coumarins, African Journal of Pure and Applied Chemistry, 4,(2010), 74-86
G. Cravotto, G.M. Nano, G. Palmisano, S. Tagliapietra, An asymmetric approach to coumarin anticoagulants via hetero-Diels– Alder cycloaddition, Tetrahedron: Asymmetry, 12, (2001), 707–709
O. Kayser, H. Kolodziej, Antibacterial Activity of Extracts and Constituents of Pelargonium sidoides and Pelargonium reniforme, Planta Med., 63, (1997) 508–510
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Phenol derivatives have been reacted with aryl halides under
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is
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between glycerol and bromobenzene. This reaction is achieved
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in aqueous solutions rather it acts as heterogeneous catalyst.
Therefore, it is filtrated at the end of the reaction and reused several
times. Accordingly, new compound were prepared by reacting
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