تصف هذه الدراسة طريقة تحليلية مطورة لتقـدير المركبـات الآتيـة: كاربينوكـسامين ماليئـات،
ديكستروميتورفان هيدروبروميد و بسودوافدرين هيدروكلوريد في مزائج نقية و في مستحـضرات دوائيـة
باستعمال الكروماتوغرافيا السائلة عالية الأداء chromatography liquid performance High.
أجري التحليل على عمود من السيليكا (6 ميكرون)، و استخدم كطور متحرك مزيج مؤلف من الإيتانول ـ
محلول خلات الأمونيوم M 05.0 و بنسب قدرها [85 : 15 [ على الترتيب، و كاشف يعمل عند طول موجة
قدرها nm 276 و معدل تدفق هو 1 مل/دقيقة. النتيجة كانت هناك خطية في مجال التراكيز المدروسـة،
حيث كانت قيم معامل الارتباط لجميع المواد المدروسة 9996.0 > R .
A simple and accurate method was developed for the analysis of
carbinoxamine maleate, dextromethorphan hydrobromide and
pseudoephedrine hydrochloride content in pure form and pharmaceutical
preparations using HPLC. Analysis was conducted on a silica column (6 μm)
with mobile phase consisting of ethanol – ammonium acetate (0.05 M) in rate
[85:15] respectively, and at detection wavelength of 276 nmand flow rate 1ml/ min.
Results were linear (correlation coefficient R > 0.9996) in the range of the
studied concentrations for the active materials. The relative standard
deviations (n=6) of intra and interday assay were 0.931%, 1.527% for
carbinoxamine maleate and 0.717%, 1.058 % for dextromethorphan
hydrobromide and 0.309%, 0.891% for pseudoephedrine hydrochloride,
respectively. This method, proved to be easy, precise and economical, is useful
for quality control of pharmaceutical drugs industrial samples.
References used
Duterhoff, H. und Kover, K-M. (1977). Identifizierung von Arzneistoffen, Stuttgart, Germany
David Harvey. (2000). Modern Analytical chemistry, Depauw University, USA
Silverstem, R.M. and Webster, F. X. (1998). Spectrometric Identification of Organic Compounds, sixth Edition State of University of New York
A simple and rapid analytical method for routine quantification of Hyoscine
butyl bromide (scopolamine butyl bromide) in liquid oral formulations by highperformance
liquid chromatography was developed and validated. The oral
solution samples can be directly analyzed by reversed-phase HPLC on Intersil
ODS-3.
spectrophotometric and chromatographic methods was used for
determination of five water-soluble vitamins, including : Thiamine
HCl (B1), Ascorbic acid (VC), Niacinamide (PP), Cyanocobalamin
(B12), Riboflavin (B2) in this research.
The conditions
An analytical chromatographic method for determination of total
benzalkonium chloride in eye drops preparations samples containing
gentamicin sulphate, tobramicin and viscous eye drops samples containing
fusidic acid has been developed.
The purpose of this article is how to determine simultaneously the content of
some Anti-Inflammatory (NSAIDS):, Ketoprofen, Flurbiprofen, Orphenadrine
Citrate (Muscle relaxant( and Clopidogrel Bisulfate (Anti-thrombocytopenia( in
pure and pharmace
Ninety-nine randomized samples of milk and white cheeses were collected
from five districts in Damascus city during 2012-2013 to determinef Aflatoxin
M1 using High Performance Liquid Chromatography (HPLC). The procedure
for determination of Aflato