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Register a new userControl and evaluation the bactericidal effect of Povidone-Iodine solutions common in the local market
مراقبة و تقييم الفعالية المضادة للجراثيم لمحاليل البوفيدون اليودي الشائعة في السوق المحلية
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Added by
Tishreen University ورقة بحثية
Publication date
2015
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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يُعدّ اليود الحر (I2) في مطهر البوفيدون اليودي مسؤولاً بشكل مباشر عن فعاليته المطهرة, حيث تزداد هذه الفعالية بشكل يتناسب مع تركيز الشركات اليود الحر. تهدف هذه الدراسة إلى مقارنة بعض محاليل البوفيدون اليودي المسوقة محلياً مع محلول مصنّع من قبل إحدى الأجنبية Betadine® و الذي اعتبر كشكل مرجعي للمقارنة. تم الحصول على العينات التجارية (PVP-I 10%) من ثلاث شركات محلية (A, B, C) مع اختيار طبخة واحدة من كل شركة. شمل البحث مراقبة تركيز اليود الحر, درجة الحموضة بالإضافة إلى تقييم الفعالية المضادة للجراثيم بطريقة الانتشار بالأقراص و سرعة تأثير المطهر على كل من Staphylococcus aureus و Escherichia coli. أبدت محاليل الشركات المحلية قيم pH منخفضة بالمقارنة مع محلول البيتادين الأجنبي, من جهة أخرى أبدت المحاليل التجارية لدى استخلاص اليود الحر منها بالهيبتان احتواءها على تراكيز كافية من اليود الحر مع ظهور أفضلية لإحدى الشركات. ترافق ارتفاع مستوى اليود الحر مع ازدياد في قطر التثبيط و السرعة في الفعل القاتل للجراثيم.
The free iodine (I2) in povidone-iodine (PVP-I) solutions is responsible for its bactericidal activity, the bactericidal effect is steadily increased with the free iodine concentration. This study aims to compare some of povidone-iodine solutions common at the local market with one solution produced by Mundipharma company (Betadine®) which used as a reference. Commercial samples (PVP-I 10%) were obtained from three local companies (A, B, C), with one batch from each company. The research included controlling free iodine concentration, pH and evaluation of bactericidal activity by using disc diffusion method and rapidity of the bactericidal activity on both Staphylococcus aureus and Escherichia coli. The local samples solutions showed low pH values compared with Betadine®, furthermore, all the solutions extracted by heptane showed high levels of free iodine with a preference for one local company. The high level of free iodine was accompanied with an increase of inhibition diameter and rapidity of bactericidal effect.
References used
ATEMNKENG, M. A; PLAIZIER-VERCAMMEN, J; SCHUERMANS, A. Comparison of free and bound iodine and iodide species as a function of the dilution of three commercial povidone–iodine formulations and their microbicidal activity. International Journal of Pharmaceutics. 317, 2006, 161–166
BERKELMAN, R. L; HOLLAND, B. W; ANDERSON, R. L. Increased Bactericidal Activity of Dilute Preparations of Povidone-Iodine Solutions. Journal of Clinical Microbiology. 15, 1982, 635-639
BODRUMLU, E; ALACAM, T. Evaluation of Antimicrobial and Antifungal Effects of Iodoform-Integrating Gutta-Percha. Journal of the Canadian Dental Association. 72, 2006, 733-737
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