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Control and evaluation the bactericidal effect of Povidone-Iodine solutions common in the local market

مراقبة و تقييم الفعالية المضادة للجراثيم لمحاليل البوفيدون اليودي الشائعة في السوق المحلية

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 Publication date 2015
  fields Pharmacy
and research's language is العربية
 Created by Shamra Editor




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The free iodine (I2) in povidone-iodine (PVP-I) solutions is responsible for its bactericidal activity, the bactericidal effect is steadily increased with the free iodine concentration. This study aims to compare some of povidone-iodine solutions common at the local market with one solution produced by Mundipharma company (Betadine®) which used as a reference. Commercial samples (PVP-I 10%) were obtained from three local companies (A, B, C), with one batch from each company. The research included controlling free iodine concentration, pH and evaluation of bactericidal activity by using disc diffusion method and rapidity of the bactericidal activity on both Staphylococcus aureus and Escherichia coli. The local samples solutions showed low pH values compared with Betadine®, furthermore, all the solutions extracted by heptane showed high levels of free iodine with a preference for one local company. The high level of free iodine was accompanied with an increase of inhibition diameter and rapidity of bactericidal effect.



References used
ATEMNKENG, M. A; PLAIZIER-VERCAMMEN, J; SCHUERMANS, A. Comparison of free and bound iodine and iodide species as a function of the dilution of three commercial povidone–iodine formulations and their microbicidal activity. International Journal of Pharmaceutics. 317, 2006, 161–166
BERKELMAN, R. L; HOLLAND, B. W; ANDERSON, R. L. Increased Bactericidal Activity of Dilute Preparations of Povidone-Iodine Solutions. Journal of Clinical Microbiology. 15, 1982, 635-639
BODRUMLU, E; ALACAM, T. Evaluation of Antimicrobial and Antifungal Effects of Iodoform-Integrating Gutta-Percha. Journal of the Canadian Dental Association. 72, 2006, 733-737
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