The free iodine (I2) in povidone-iodine (PVP-I) solutions is responsible for its
bactericidal activity, the bactericidal effect is steadily increased with the free iodine
concentration. This study aims to compare some of povidone-iodine solutions c
ommon at
the local market with one solution produced by Mundipharma company (Betadine®) which
used as a reference. Commercial samples (PVP-I 10%) were obtained from three local
companies (A, B, C), with one batch from each company. The research included
controlling free iodine concentration, pH and evaluation of bactericidal activity by using
disc diffusion method and rapidity of the bactericidal activity on both Staphylococcus
aureus and Escherichia coli. The local samples solutions showed low pH values compared
with Betadine®, furthermore, all the solutions extracted by heptane showed high levels of
free iodine with a preference for one local company. The high level of free iodine was
accompanied with an increase of inhibition diameter and rapidity of bactericidal effect.
The aim of this clinical study compared the use of normal
saline versus (PVP-I) as Irrigating solution during bone
removal on the following edema of The surgical extraction of
the lower third molar impacted.
