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Register a new userImportant of Spect 99mtc-Hmpao for Detecting Brain Perfusion Changes in Mentally Retarded Autistic Patients
أهمية التصوير الومضاني الطبقي 99mTc-HMPAO SPECT في كشف تبدلات التروية الدموية الدماغية في مرضى التوحد
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Tishreen University ورقة بحثية
Publication date
2013
fields
Medicine
and research's language is
العربية
Authors
حمزة شبيب( باحث )
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Shamra Editor
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أجري الفحص الومضاني الطبقي للدماغ 99mTc-HMPAO SPECT ل 22 طفلاً مصاباً بالتوحد و التخلف العقلي و ل 8 أطفال يعانون من التخلف العقلي كشاهد. تبين بنتيجة الفحص الومضاني الطبقي أن هناك نقص تروية دماغية مؤثراً في الفصوص الصدغية و المنطقة المهادية و النوى القاعدية للمتوحدين, مقارنة مع مجموعة الشاهد. تناسبت الأعراض السريرية للمتوحدين مع نقص التروية في المنطقة المهادية، و لم تتناسب مع نقص التروية في بقية المناطق. لم يثبت إحصائياً فروق مؤثرة بالنسبة لعمر المرضى، تقدير عمرهم العقلي، وزنهم، و محيط رأسهم بين المتوحدين و مجموعة الشاهد، بينما كان هناك فروق إحصائية مؤثرة بين المتوحدين و مجموعة الشاهد بالنسبة لمقياس تقييم التوحد الطفولي، قائمة السلوك الشاذ التي تشمل الإثارة، البلادة، التكرارية، النشاط الزائد و الإفراط في الكلام. أثبتت الدراسة فعالية المعالجة المناسبة في بعض المتوحدين الذين لديهم نقص تروية دماغية بدون وجود تبدلات بنيوية دماغية سواء بالتصوير الطبقي المحوري أو بالرنين المغناطيسي.
99mTc HMPAO single-photon emission computed tomography (SPECT) brain perfusion was conducted in 22 mentally retarded autistic individuals and 8 patients with mental retardation as control group. Autistic patients had significantly lower perfusion than control group in the following brain regions: temporal lobes, basal ganglia, and thalami. Signs and symptoms were correlated to decreased regional perfusion in the thalamic region, but no correlation between symptoms and decreased regional perfusion in the rest of the brain lobes. Statistically, no significant differences between autistic and control group for, age, assessment of mental age, weight and head circumference, while there were statistically significant differences between autistic patients and control group related to childhood autism rating scale, and aberrant behavior checklist (irritability, lethargy, stereotypic behaviors, hyperactivity and excessive speech). The study demonstrated the effectiveness of appropriate treatment in some autistic patients with brain hypoperfusion on 99mTc HMPAO-SPECT without detection of structural changes on CT or MRI.
References used
BAILEY, A, PHILIPS, W, and RUTTER, M. Autism: Towards an Integration of Clinical, genetic, Neuropsychological, and Neurobiological Perspective. J Child Psychol Psychiatry. U.S.A. Vol. 37, No. 16, 1996- pp. 877-900
KANNER, L. Autistic disturbances of Effective Contact. Nervous Child. England. 2, 1943-pp. 217-250
BELMONTE, MK, ALLEN, G, BECKEL-MITCHENER, A, et al. Autism and Abnormal Development of Brain Connectivity. Journal of Neuroscience. England. Vol. 24, No. 42, 2004- pp. 9228-9231
GOODMAN, R. Infantile Autism: A syndrome of Multiple Primary Deficits. J Autism Dev Disord. U.S.A. Vol. 19, No3. 1989- pp. 409-424
GILLBERG, C, and COLEMAN, M. Autism and Medical Disorders: A review of the Literature. Developmental Medicine and Child Neurology. England. Vol. 38, No. 3, 1996- pp. 191-202
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The aim of this research is to study the problem of social
withdrawal of mentally retarded children and its relation with the
variables of parents' wrong treatment methods, the degree of children's
mental retardation and sex.
The asymmetric face is common so that increased interest in it .
there are different ways to assess the asymmetry. Computed
tomography is an accurate way that enable the examiner for reading the
face at three planes ,and present three-dimensional
information on the
cranial mandibular Complex whereas (3D) analysis is essential for
making a precise diagnosis of craniofacial morphology . Aim : This
research aims to study the asymmetric at the facial patterns
malocclusion (class I. Class III) using CT .
This study was carried at Al Assad hospital, Lattakia. It is a retrospective study of uterine leiomyoma patients who had been accepted in the Department of Gynecology during the period between 1/6/2011 and 1/6/2013 .
The study included 103 patients.
We documented information for each patient: age, signs and symptoms, number of pregnancies and births, clinical and vaginal examination, ultrasound, blood tests: hemoglobin, hematocrit and red cell values, and the type of surgical treatment.
The prevalence of uterine leiomyoma in this study was 5.1%.
The most clinical manifestation of uterine leiomyoma was abnormal uterine bleeding (63.1 %).
Hemoglobin was less than 12 g / dL at 59.22% of cases.
Hematocrit was less than 36% at 57.28 % of cases.
This confirms that uterine leiomyoma patients are at high risk of anemia,
(we depended on cut off point of WHO for hemoglobin and hematocrit), and the anemia is by iron deficiency because the average values of red blood cells were less than normal.
Myomectomy is the surgical option among young women who want to reproduce or maintain menstruation, while abdominal and vaginal hysterectomy are surgical options for older women or who have completed their reproductive life .
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