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Register a new userThe role of 99mTc-Sestamibi in the Distinction of Histopathologic Type of Hepatocellular Carcinoma
دور التصوير الومضاني بال Sestamibi -Tc99m في تحديد النوع النسيجي لسرطان الخلية الكبدية
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تمت دراسة 32 آفة سرطانية في 30 مريضاً بسرطان الخلية الكبدية بوساطة التصوير الومضاني باستخدام العقار المشع 99mTc-MIBI والكاميرا الغامية (سوف نشير للعقار المشع اختصاراً بـ الميبي المشع) لتقييم أنموذج التثبيت للعقار المشع في الآفات وعلاقته بالأنموذج النسيجي لسرطان الخلية الكبدية. تم تشخيص كل الآفات بوساطة الخزعة المأخوذة عبر الجلد. أظهر التصوير الومضاني زيادة تثبيت الميبي المشع في 14 آفة ونقصاً للتثبيت في 18 آفة. كل الآفات التي أظهرت زيادة في التثبيت للعقار المشع كانت من النوع المسمط (Compact). من بين الآفات التي أظهرت نقصاً في تثبيت العقار المشع، 17 آفة كانت من النوع التربيقي (Trabecular) بينما أظهرت آفة واحدة (ناقصة التثبيت للميبي المشع : ورم متنخر) أنها من النوع المسمط. تقترح هذه النتائج أن أنموذج التثبيت للميبي المشع في سرطان الخلية الكبدية يقسم إلى أنموذجين إيجابي وسلبي وتتوافق هذه الأشكال من التثبيت مع البناء النسيجي لسرطان الخلية الكبدية.
32 lesions in 30 patients with Hepatocellular carcinoma (HCC) were studied using gamma camera and technetium-99m metoxyisobutylisonitrile (99mTc-MIBI) to evaluate the pattern of uptake of 99mTc-MIBI in the lesions and the relationship between the uptake pattern and histopathology of HCC. All lesions were diagnosed as HCC by percutaneous needle biopsy. 14 of 32 lesions showed positive uptake of 99mTc-MIBI, while the other 18 showed negative uptake. All of the lesions which showed positive uptake were of the compact type. Of the 18 lesions that showed negative uptake, 17 were of the trabecular type while one was of the compact type (necrotic compact tumor). These results suggest that the pattern of 99mTc-MIBI accumulation in HCC is divided into positive and negative types and those uptake patterns are corresponded to tissue structure of HCC.
References used
OKADA, RD, GLOVER, D,. GAFFINEY, T, et al. Myocardial Kinetics of Technetium-99m-Hexasis-2-methylpropyl-isonitrile. Circulation. Vol. 77, No. 2, 1988- 491-498
AKTOLUN, C, BAYHAN, H, KIR, M, et al. Clinical Experience with Tc-99m MIBI Imaging in Patients with Malignant Tumours: Preliminary Ressults and Comparison with Tl-201. Clin Nucl Med. Vol. 17, No. 3, 1992 - 171-176
MAFFIOLI, L, STEENS, J, PAUWELS, E. et al. Applications of 99mTc-sestamibi in Oncology. Tumori. Vol. 82, No. 1, 1996- 12-21
DELMON-MOINGEON, LI, PIWNICA-WORMS, D, VON DEN ABBEELE, AD. et al. Uptake of Cation Hexasis (2-methoxyisobutyleisonitrile)-Technetium-99m by Human Carcinoma Cell Line in Vitro. Cancer Res. Vol. 50, No. 7, 1990- 2198-2202
PIWNICA-WORMS, D, and HOLMAN, BL. Noncardiac Applications of Hexasis-(alkylisonitrile)-Technetium-99m Complexs. J Nucl Med. Vol. 31, No. 7, 1990- 1166-1167
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112 patients with suspected breast lesions were investigated using Scintimammography with 99mTc-MIBI, mammography and magnetic resonance to compare the diagnostic accuracy of Scintimammography with that of mammography and magnetic resonance in the d
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Hepatocellular carcinoma (HCC) is a common malignancy and the
leading cause of death worldwide, due to late detection and high
recurrence rates. Osteopontin (OPN) has various functions,
including prevention of apoptosis and modulation of angiogene
sis
which lead to tumor formation and progression, although the exact
mechanisms for the development of cancer are still unknown.
99mTc HMPAO single-photon emission computed tomography (SPECT) brain perfusion was conducted in 22 mentally retarded autistic individuals and 8 patients with mental retardation as control group. Autistic patients had significantly lower perfusion tha
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Perfect localization of hyperactive parathyroid glands is useful to minimize operation time, incision and reduce patient morbidity. 52 patients with hyperparathyroidism were investigated, 14 with primary and 38 with secondary hyperparathyroidism foll
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Despite of the great evolution in the field of radiological technologies ,
panoramic radiography is still the most important radiological –diagnostic
method in the maxillofacial area .
Panoramic radiographs reveal a wide area of tissue in one x-ra
y.
In addition . It seems to be preferred by the maxillofacial surgeon due to its
simplicity and rapidity of application , and low dose of radiation.
In oral and maxillofacial fractures , panoramic radiography is still the best
way of having a quick and preliminary diagnosis of most of these fractures.
In our study we made a precise diagnosis of about 88.79% of our cases by
using this method .
For that we recommend to use panoramic radiography in most cases of oral
and maxillofacial injuries .
In cases that clinical diagnosis does not match the panoramic radiography
diagnosis we must look for another radiological method.
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