Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userScintimammography with 99mTc-Sestambibi Compared to Mammography and Magnetic Resonance Imaging for Breast Cancer
التصوير الومضاني لسرطان الثدي بالـ 99mTc-Sestamibi و مقارنته مع التصوير الشعاعي و الرنين المغناطيسي
1389
1 10
0
(
0
)
Authors
حمزة شبيب( باحث )
Created by
Shamra Editor
Ask ChatGPT about the research
تمت دراسة 112 مريضاً بآفات مشكوك في طبيعتها في الثدي بواسطة التصوير الومضاني بالميبي المشع (99mTc-MIBI) و التخطيط الشعاعي للثديين (Mammography) و الرنين المغنطيسي(Magnetic resonance)، للمقارنة بين الوسائل التشخيصية السابقة من حيث دقة (Accuracy) التشخيص للسرطان البدئي. تم أخذ الخزعة الاستئصالية للتشخيص النسيجي بعد أسبوع إلى عشرة أيام من الفحص بالميبي المشع. تم تشخيص 70 حالة سرطانية (55 سرطاناً مجسوساً و 15 غير مجسوس) و كانت بقية الحالات آفات سليمة (30 آفة سليمة مجسوسة و 12 حالة غير مجسوسة). تبين من الدراسة أن حساسية الفحوص الثلاثة كانت عالية و متقاربة (89% للفحص الومضاني، 90% للتخطيط الشعاعي و 94% للرنين المغنطيسي)، بينما تميز الفحص الومضاني بنوعية عالية (86%) مقارنة بالتخطيط الشعاعي (21%) و الرنين المغنطيسي (50%). هذه النوعية العالية للفحص إضافة إلى قيمة التنبؤ الإيجابية (91%) و السلبية (82%) العالية مقارنة مع التخطيط الشعاعي (65%) و الرنين المغنطيسي (76%) منحت التصوير الومضاني دقة أعلى في التشخيص (87%) مقارنة مع 64% للتخطيط الشعاعي و 78% للرنين المغنطيسي. و هكذا فإن استخدام التصوير الومضاني بصفته وسيلة متممة يمكن أن يزيد حساسية الفحوص الأخرى في اكتشاف سرطان الثدي. يمكن للتصوير الومضاني أن يلعب دوراً في التقليل من الخزعات الاستئصالية في أولئك المرضى الذين لديهم كتلة ثديية مجسوسة و غير محسومة التشخيص.
112 patients with suspected breast lesions were investigated using Scintimammography with 99mTc-MIBI, mammography and magnetic resonance to compare the diagnostic accuracy of Scintimammography with that of mammography and magnetic resonance in the detecting of primary breast cancer. Excisional biopsy was taken after 7-10 days of Scintimammography. 70 patients were diagnosed with breast cancer; 55 palpable and 15 non-palpable lesions, while 42, 30 palpable and 12 non-palpable were diagnosed as benign lesions. The sensitivity of the three methods were high and approximate (89% by Scintimammography, 90% by mammography and 94% by magnetic resonance), while Scintimammography showed higher specificity (86%) versus 21% for mammography and 50% for magnetic resonance. The high specificity in addition to high positive (91%) and negative (82%) predictive values of Scintimammography resulted in a highly accurate diagnostic (87%) method compared to mammography (64%) and magnetic resonance (78%) procedures. Through the complementary use of Scintimammography it is possible to increase the sensitivity for the detection of breast cancer. In patients in whom the status of a palpable breast mass remains unclear, Scintimammography may help to reduce the amount of unnecessary biopsies.
References used
PARKIN, DM, PISANI, P, FERLAY, J, et al. Global Cancer Statistics. CA Cancer J Clin. Vol. 49, No. 1, 1999- pp. 33-64
POLLEI, SR, METTLER, FA, BARTOW, SA, et al. Occult Breast Cancer: prevalence and Radiographic Detectability. Radiology. Vol. 163, No. 2, 1987- pp. 459-462
BASSET, LW, LIU, TH, GIULIANO, AE, et al. The Prevalence of Carcinoma in Palpable Versus Impalpable, mammographically detected lesions. AJR. Vol. 157, No. 1, 1991- pp. 21-24
SICKLES, EA. Mammographic Features of Early Breast Cancer. AJR. Vol. 143, No. 3, 1984- pp. 461-464
MOSKOWITZ, M. The Predictive Value of Certain Mammographic Signs in Screening for Breast Cancer. Cancer. Vol. 51, No. 6, 1983- pp. 1007-1011
rate research
Read More
32 lesions in 30 patients with Hepatocellular carcinoma (HCC) were studied using gamma camera and technetium-99m metoxyisobutylisonitrile (99mTc-MIBI) to evaluate the pattern of uptake of 99mTc-MIBI in the lesions and the relationship between the upt
ake pattern and histopathology of HCC. All lesions were diagnosed as HCC by percutaneous needle biopsy. 14 of 32 lesions showed positive uptake of 99mTc-MIBI, while the other 18 showed negative uptake. All of the lesions which showed positive uptake were of the compact type. Of the 18 lesions that showed negative uptake, 17 were of the trabecular type while one was of the compact type (necrotic compact tumor). These results suggest that the pattern of 99mTc-MIBI accumulation in HCC is divided into positive and negative types and those uptake patterns are corresponded to tissue structure of HCC.
Perfect localization of hyperactive parathyroid glands is useful to minimize operation time, incision and reduce patient morbidity. 52 patients with hyperparathyroidism were investigated, 14 with primary and 38 with secondary hyperparathyroidism foll
owing renal failure. Surgery has been done on 36 patients (14 with primary and 22 with secondary hyperparathyroidism). Sensitivity of 99mTc-tetrofosmin scintigraphy was estimated after surgical removal of Hyperfunctioning glands and compared with that of ultrasound and magnetic resonance imaging. The sensitivity of 99mTc-scintigraphy (79,5%) exceeded the sensitivity of ultrasound (68,2%) and magnetic resonance imaging (71,6%). Parathyroid hormone (P.T.H.) and calcium levels in serum were compared with positive 99mTc-tetrofosmin Scintigraphy. Results demonstrated correlation between positive 99mTc-tetrofosmin scintigraphy and parathyroid hormone levels with significant statistical difference of P < 0.001 and all patients with primary hyperparathyroidism with P.T.H. levels of 195 pg/ml or more were scintigraphically positives. All patients with secondary hyperparathyroidism with P.T.H. levels of 1200 or more were positives. No correlation was detected between calcium levels and positivity or negativity of scintigraphic results.
99mTc HMPAO single-photon emission computed tomography (SPECT) brain perfusion was conducted in 22 mentally retarded autistic individuals and 8 patients with mental retardation as control group. Autistic patients had significantly lower perfusion tha
n control group in the following brain regions: temporal lobes, basal ganglia, and thalami. Signs and symptoms were correlated to decreased regional perfusion in the thalamic region, but no correlation between symptoms and decreased regional perfusion in the rest of the brain lobes. Statistically, no significant differences between autistic and control group for, age, assessment of mental age, weight and head circumference, while there were statistically significant differences between autistic patients and control group related to childhood autism rating scale, and aberrant behavior checklist (irritability, lethargy, stereotypic behaviors, hyperactivity and excessive speech). The study demonstrated the effectiveness of appropriate treatment in some autistic patients with brain hypoperfusion on 99mTc HMPAO-SPECT without detection of structural changes on CT or MRI.
This research aims to developing new method for breast tumors extraction and
features detection in breast magnetic resonance images by depending on clusteringand
image processing algorithms. At the beginning, one of clustering algorithms was used f
or
image segmentation and grouping pixels by their gray scale values. Then morphological
operations were implemented in order to remove noise and undesired regions, after that
suspected areas were extracted. Finally some shape features for extracted area were
detected, this features could be very useful for tumors diagnosis. A database consisted of
96breast magnetic resonance images were used and proposed approach was appliedby
MATLAB program, and we obtainedbreast tumors extraction and its features and
compared them with the doctor's opinion .
Writing mammography reports can be error-prone and time-consuming for radiologists. In this paper we propose a method to generate mammography reports given four images, corresponding to the four views used in screening mammography. To the best of our
knowledge our work represents the first attempt to generate the mammography report using deep-learning. We propose an encoder-decoder model that includes an EfficientNet-based encoder and a Transformer-based decoder. We demonstrate that the Transformer-based attention mechanism can combine visual and semantic information to localize salient regions on the input mammograms and generate a visually interpretable report. The conducted experiments, including an evaluation by a certified radiologist, show the effectiveness of the proposed method.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
