Objective:
Evaluate sensitivity and specificity of nitrite test to urine culture(gold standard) for
diagnosing urinary tract infection in patients with sickle cell anemia with urinary
symptoms and signs.
Methods:
The study sample included 79 chi
ldren aged 2 to 14 years with SCA presenting with
fever (temperature >38°C),abdominal pain, urgency, dysuria or increased urinary
frequency who referral to the general pediatric clinic and the children's ambulance
department in Tishreen University Hospital in Lattakia during( 2016-2017).
Midstream urine specimen was collected from children. Samples were subjected to nitrite
test, culture and sensitivity.
Results :
There was significant bacteriuria in 17 (21.5%) children with SCA. A positive test
for nitrite was obtained in 12 of the 17(70.5%) children. The nitrite test has a specificity of
95.2% in detecting bacteriuria, a sensitivity of 70.6%, a positive predictive value of 80%
and a negative predictive value of 92%. A positive nitrite test was significantly associated
with bacteriuria, while a negative test was also significantly associated with an absence of
bacteriuria.
Worldwide, iron deficiency anemia (IDA) is the most common nutritional deficiency,
and its management remains a challenge in many cases.(OIT)Oral iron therapy, in appropriate
doses and for a sufficient duration, is an effective first-line strategy
for most patients.
But some patients do not experiencean optimal response to(OIT).The need is still
current and clinically relevant for predictors of response to OIT. Hepcidin-25, a major regulator
of iron metabolism, may be use as a reliable guide for the use of iron and be one of
them.112 patientswith IDA were enrolled in this follow up clinical trial, Selected from two
university, hospitals in Damascus between JUNE2015 and JUNE2016. For patients who
met the inclusion criteria, Baseline CBC, iron studies, and serum hepcidin-25 were measured,
and then they received a 14-day course of oral iron (ferrous gluconate 325mg/ 3 times
daily). Patients who achieved <1g/dl increase in Hb in 14 days were categorized as “nonresponders”.
Screening hepcidin levels were (40.18± 86.35) versus (6.37±10.37)(p=
0.041(innonresponders versus responders to oral iron trial. HepcidinCutoff of >14.3 ng/ml,
showed sensitivity of 40%,specificity of 90.2%, andpositive predictive value of 60% andnegative
predictive value of 80% for predicting nonresponsiveness to oral iron.We conclude
that serum hepcidin25predicts poorly nonresponsivenesstooral iron therapy in IDA
patients, but it is superior to ferritin and TSAT for this purpose.
Hepcidin-25 is a peptide hormone plays an important role in
regulating the systematic iron homeostasis. This paper was
conducted to study the correlations of Hepcidin with some iron
status markers and red cell indices among patients with iron
def
iciency anemia (IDA) and healthy controls in Damascus. Our
study comprised 20 IDA patients (Hb≤11 g/dl for men and
women,Tsat≤20% and ferritin <30 ng/dl) and 10 healthy non
IDA controls. Complete hemogram was performed, iron status
markers (serum iron, total iron binding capacity and ferritin)
were measured and transferrin saturation was calculated .
Objective: To determine if there is a relationship between milk feeding and iron
deficiency anemia ,and to determine the association between anemia and infant birth order,
time of introduction solid foods, socioeconomic state , Birth weight less th
an 3000 gram .
Methods: A total of 300 children between 6 and 24 months old were attended at
Alassad and TISHREEN Hospitals were enrolled in the Study during the period July
2015-July 2016,a patient –case study ,patient definition:an infant with anemia ,case
definition:an infant without anemia we calculated the odd ratio with confidence intervals
95%,we used chi-square and TStudent test.
Results: by studying the relationship between anemia and milk feeding we found the
odd ratio=5.6,it means that the risk to have anemia is 6 times more in infants consumping
breast milk.by using chi-square test to study the relationship between anemia and both of
infant order,socioeconomic state,the resuts were :there is no association between birth
order and anemia but there is a big association between anemia and socioeconomic
state.the result of studying the relationship between taking iron complemnts and anemia
:the risk of anemia is 2 times more in infants who do not take iron ccomplemnts.there was
no relationship between introducing solid foods before the age 6 months and having
anemia .there was no association between low birth weight infants and having anemia.
In this prospective study done in Syria from mars 2014 to
February 2015, Mean serum hemoglobin ,serum hematocrit,
serum ferritin, and the ratio of serum iron to total iron-binding
capacity were investigated in 100 children aged ( 2-11) years.
The
study aimed at assessing the extention of anemia in
giardiasis intestinalis in Syrians children.
we delivered 8,000 IU epoetin three times per week to 30 anemic cancer patients for two months.we measured serum erythropoietin level before the initiation of the treatment.Hemoglobin concentration and other hematological parameters were measured dur
ing the treatment. 53% of patients responded to the treatment within 8 weeks. 71% of patients with serum erythropoietin < 100 U/L responded, whereas 27% with values > 100 U/L did.80% of patients with hematological malignancies responded, whereas 39% of patients with solid tumors did .Reticulocyte increment after two weeks in responder patients was higher than non responders.response rate was higher in patients with Hb increment > 0.5 g/dL after 2 weeks ( 83% versus 31% ), and in those with Hb increment > 1 g/dL after 4 weeks ( 93% versus 14% ). response to erythropoietin can be predicted by pretreatment serum erythropoietin level together with early changes in other hematological parameters.
Objective: Breath holding spells is a common case in children aged 5months to 6
years, and often misinterpreted with epileptic seizures.we did clinical and epidemiological
assessment for BHS.We documented the relation between sex, age, familial his
tory and the
episodes nature blue, pale or mixed.
Materials & Methods: This was a cross-sectional study in which a total of 50
children
with BHS, admitted to the out patient neuropediatric clinic 2013-2014. We took full
medical history and did the investigations to eliminate the differential diagnosis.
Results:Most patient were 7-24 month, we noticed parental consanguinity 87% and
familial history in 56%.The spells were cyanotic 70%. Anger and pain were the more
frequent risk factors 64%,60%.Anemia found in 58% of patient.Half of the patient have
socioeconomic problems.And most of them from nuclear family 66%.
Conclusion:The study mentioned the types of spells and the risk factors and the
importance of look for anemia.
This study evaluates the maternal immunity to chicken anemia virus in broiler chicks.
Two groups, of only one day old chicks, have been breeding .
The first group was obtained from a vaccinated breeder flock against chicken anemia virus .The s
econd one was obtained from unvaccinated breeder flock against the same disease.
Blood samples were collected from the chicks every five days starting from the first day of their birth.
The test was performed enzyme –linked immunoassay (ELISA) to measure antibody titer for chicken anemia virus in these birds.
The research results have shown that the average antibody levels for the first group was (3344) for the one day old chicks while (4144) for the second group.
The results have also shown that there was a decrease in the average antibody levels during 15 days.
This research has proved prevalence of disease in unvaccinated flock
This study included 502 children between 0,5-15 years old. They were all subjected to duodenal biobsy for several reasons, and underwent investigations; Hb, MCV, MCH, MCHC and RDW.
The prevalence of celiac disease among anemic children was higher
than nonanemic patients (36,04% vs 12,14%). The mean duration of compliance was higher in both anemic children and celiac patients than in comparing groups .The mean levels of Hb,MCV,MCH and MCHC were lower in celiac group, while RDW was higher. Anemia was the most common presentation of celiac disease and it was seen in 77% among celiac children, while failure to thrive was detected in 43% of celiac group. Clinicians should consider celiac disease as a possible cause of anemia in all subjects with unexplained or refractory anemia
