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Register a new userThe importance of serum erythropoietin measurement before the Treatment of anemia with Recombinant Human Erythropoietin in Cancer Patients in Lattakia city
أهمية قياس إريتروبويتين المصل قبل البدء بمعالجة فقر الدم بالإريتروبويتين البشري المؤشب عند مرضى الأورام في مدينة اللاذقية
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تم إعطاء epoetin بجرعة 8,000 IU ثلاث مرات أسبوعياً لمدة شهرين إلى 30 مريض أورام لعلاج فقر الدم لديهم. تم معايرة الإريتروبويتين قبل العلاج و مراقبة الخضاب و المشعرات الدموية أثناء العلاج . تحققت الاستجابة عند 53% من المرضى, و كان معدل الاستجابة أعلى عند وجود انخفاض في مستوى الإريتروبويتين ( 100 U/L) (71% مقابل 27%) . كما كان معدل الاستجابة أعلى عند المصابين بأورام غير صلبة مقارنة مع الأورام الصلبة ( 80 % مقابل 39% ). كان متوسط ارتفاع الشبكيات بعد أسبوعين أعلى عند المرضى المستجيبين مقارنة مع غير المستجيبين .كان معدل الاستجابة أعلى عندما كان تحسن الخضاب بعد أسبوعين < 0.5 g/dL نسبة للخضاب البدئي (83 % مقابل 31%) و عندما كان تحسن الخضاب بعد 4 أسابيع < 1 g/dL نسبة للخضاب البدئي (93% تقريباً مقابل 14%). يمكن التنبؤ بالاستجابة على العلاج بالإريتروبويتين من خلال القيمة المصلية للإريتروبويتين قبل العلاج بالمشاركة مع التغيرات الباكرة في المشعرات الدموية الأخرى .
we delivered 8,000 IU epoetin three times per week to 30 anemic cancer patients for two months.we measured serum erythropoietin level before the initiation of the treatment.Hemoglobin concentration and other hematological parameters were measured during the treatment. 53% of patients responded to the treatment within 8 weeks. 71% of patients with serum erythropoietin < 100 U/L responded, whereas 27% with values > 100 U/L did.80% of patients with hematological malignancies responded, whereas 39% of patients with solid tumors did .Reticulocyte increment after two weeks in responder patients was higher than non responders.response rate was higher in patients with Hb increment > 0.5 g/dL after 2 weeks ( 83% versus 31% ), and in those with Hb increment > 1 g/dL after 4 weeks ( 93% versus 14% ). response to erythropoietin can be predicted by pretreatment serum erythropoietin level together with early changes in other hematological parameters.
References used
VOGELZANG, NJ; BREITBAT, W; CELLA, D, et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The Fatigue Coalition. SeminHematol,34(suppl 2), 1997,4-12
ASHBURY, FD; FINDLAY, H; REYNOLDS, B, et al. A Canadian survey of cancer patients’ experiences: Are their needs being met? J Pain Symptom Manage,16, 1998, 298 –306
CELLA, D. The Functional Assessment of Cancer Therapy-Anemia (FACTAn) Scale: A new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol,34(suppl 2), 1997,13–19
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