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Register a new userThe role of intravenous magnesium sulfate in reduce of hospitalization in asthmatic children with moderate severity exacerbation
دور سلفات المغنيزيوم الوريدي في خفض نسب الاستشفاء عند مرضى النوبة الربوية الحادة متوسطة الشدة المراجعين لقسم الإسعاف
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Tishreen University ورقة بحثية
Publication date
2018
fields
Medicine
and research's language is
العربية
Created by
Shamra Editor
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هدف الدراسة: يحتاج العديد من الأطفال مع نوب ربوية حادة للاستشفاء على الرغم من تلقي العلاج التقليدي (السّتيروئيدات و السّالبوتامول الإنشاقي)، أظهرت العلاجات الحديثة فائدة تسريب سلفات المغنيزيوم وريدياُ في خفض نسب الاستشفاء عند البالغين , و لكنَّ ليس من الواضح حتى الآن فيما إذا كان لها نفس الفعالية عند الأطفال .
Objective: Many children experience acute asthma exacerbations ,Many children also require hospitalization despite treatment in an emergency department with current standard therapy (corticosteroids ,and inhaled salbutamol). These hospitalizations may be avoided if effective adjunctive therapies can be developed to adequately treat severe exacerbations.
References used
Centers for Disease Control and Prevention: National Center for Health Statistics, National Health Interview Survey Raw Data, 2011. Analysis by the American Lung Association Research and Health Education Division using SPSS and SUDAAN software
DEVI PR, KUMAR L, SINGHI SC, PRASAD R, SINGH M. Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatrics 199797–389:)5(34
GÜRKAN F, HASPOLAT K, BONAK M, DIKICI B, DERMAN O, ECE A. Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy. European Journal of Emergency Medicine 1999;6(3):2015
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Asthma exacerbations can be frequent and range in severity from relatively mild to
status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the
informations available on its inhaled role still low and conflicting, so the st
udy aim to
investigate the effect of thecombinationof MgSO4and salbutamol in the management of
acute asthma attack.
A randomized clinical trial was conducted on 76 patients, divided into two groups:
experimental (40) and control (36) patients. The trial received nebulised salbutamol with
magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three
sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse,
Sao2 and PEF were assessed.
Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2
and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4
in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects
attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with
salbutamol, appears to have benefits in the treatment of acute asthma attack.
Background: Lidocaine had shown to inhibit neural conduction and antiinflammatory
properties. The purpose of this research was to study the effect of using
intravenous lidocaine with general anesthesia drugs on opioids and inhaled anesthesics
cons
umption during surgery and the require of analgesics after surgery.
Setting: This study was carried out in the department of anesthesia and reanimation
at Tishreen University Hospital, Lattakia, Syria during 2017-2018.
Type of study: Double-blinded randomized comparative study.
This study was done to determine whether use of nebulized salbutamol therapy for
treatment of an acute attack of asthma in children is associated with hypokalaemia and if
so what is its frequency, severity and what is accompanying clinical symptoms
103 child,
aged 3 years to 14 years with asthma attack, treated with three doses of nebulized
salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium
was obtained at the beginning and after three doses of nebulized salbutamol therapy.The
mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A
decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild
hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate
hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was
accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15,
headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate
hypokalemia.
Serum levels of vitamins E and C were measured in 15 patients with Osteoarthritis
( OA ) and those patients received Magnesium 10mg /kg /day for
two weeks ,and 15 healthy subjects as a control group
Patients were classified into subgroups ,those w
ith OA according to
disease activity and /or sevirety .
pemphigus vulgaris is a life threatening relapsing disease, the first line in its
treatment is systemic steroids, and due to the high rate of side effects caused by systemic steroids in
pemphigus vulgaris patients, some immunosuppressant drugs have
been introduced as an adjuvant
steroid sparing agents, and one of these immunosuppressants is methotrexate, and in spite of the lack of
its use in pemphigus vulgaris, a few studies have shown an encouraging results of its use, and have advised
to carry out more studies about it as an immunosuppressant which has been omitted from usage in
pemphigus vulgaris for a long time.
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