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Purpose: To evaluate and compare the pharmacological characteristics and clinical efficacy of two topical steroid prednisolone preparations (Redmond®, prednisolone acetate 1%; and Pred Forte®, prednisolone acetate 1%) in reducing postoperative inflam mation in patients having phacoemulsification surgery with IOL implantation, which will support our trust in national products considering it's availability and lower costs compared with universal products. Methods: I- Laboratory Study: Direct microscopic examination of the ophthalmic suspension for both formulations. II- Clinical Study: This study was interventional, prospective, randomized controlled study included 60 eyes of patients undergoing emulsification surgery with IOL implantation. Patients were assigned to one of two treatment groups, The first group (30 eyes) received Redmond® while the second group (30 eyes) received Pred Forte® in addition to standard therapy. Study drug was administered postoperatively every 2 hours while awake for 7 days, then four times daily for 7 days, then twice daily for 7 days, then once daily for 7 days. Clinical efficacy was compared for differences in visual acuity, anterior chamber cells (scale 0-4), fundus and macula, drug's ocular adverse effects: foreign body sensation and irritation (scale 1-3), and intraocular pressure (IOP). Results were compared on day 1, day 3, 1 week, 2 weeks, and 1 month postoperatively. Results: I- Average particle size in ophthalmic suspension for both formulations was (< 1 μm). (Redmond® = 0.95 μm, Pred Forte® = 0.77 μm). II- No statistical differences in clinical efficacy or safety were seen between the two formulations tested at any time point evaluated with respect to visual acuity, anterior chamber cells, fundus and macula, foreign body sensation and irritation, and intraocular pressure (IOP). Conclusions: In this study of routine cataract patients, both prednisolone acetate 1% formulations are comparably effective and safe when administered for the reduction of inflammation after phacoemulsification surgery with IOL implantation. Direct microscopic examination showed that both formulations achieved the condition that particle size in ophthalmic suspension must be less than one micron.
Objective:Infantile spasm is one of the most epileptic syndromes in infant which respond poorly to most anticonvulsants, and the importance of research attempting to provide effective treatment and has a few side effects compared to other therapies u sed in the treatment (cortisone, ACTH, and other anti-convulsants). Materials&Methods:The study included 37 patients with infantile spasm, 5 patients were excluded. The other 32 patients were divided in two groups randomly each group 16 patients, first group were treated with vitamin B 6, the second were treated with prednisolone and patients were also divided to groups according to their ages older than one year and younger than one year, patients were followed for six months where it has made observations within two weeks of treatment.
Background& Objective: pemphigus vulgaris is a life threatening relapsing disease, the first line in its treatment is systemic steroids, and due to the high rate of side effects caused by systemic steroids in pemphigus vulgaris patients ,some immun osuppressant drugs have been introduced as an adjuvant steroid sparing agents , and one of these immunosuppressants is azathioprine, which is the most used drug by therapists, but this use was due to experience and not due to strict studies , this research studies the relationship between azathioprine and relapse in pemphigus vulgaris patients during the prednisolone reduction period. Materials & Methods: 70 pemphigus vulgaris patients have been studied, from the patients of the dermatology university hospital during the period between 1/8/2008 -29/5/2011 (the first year for collecting the sample and the rest for follow-up) they have been divided into 2 groups. The first: were treated with prednisolone plus azathioprine (30 patients ), the second : were treated with prednisolone alone (40 patients ).and after the control of the disease the dose of prednisolone was reduced gradually ,till it was stopped, and patients were observed for relapse. Results: there was no meaningful statistical difference between the two groups in the terms of relapse, as giving azathioprine did not reduce the relapse rate, and did not reduce the prednisolone dose needed to prevent relapse. Conclusion: in this study no use of azathioprine in preventing relapse in pemphigus vulgaris patients, so we advise for more studies to confirm that, and to give more attention during its prescription.
pemphigus vulgaris is a life threatening relapsing disease, the first line in its treatment is systemic steroids, and due to the high rate of side effects caused by systemic steroids in pemphigus vulgaris patients, some immunosuppressant drugs have been introduced as an adjuvant steroid sparing agents, and one of these immunosuppressants is methotrexate, and in spite of the lack of its use in pemphigus vulgaris, a few studies have shown an encouraging results of its use, and have advised to carry out more studies about it as an immunosuppressant which has been omitted from usage in pemphigus vulgaris for a long time.
Pephigus vulgaris is a recurrent life threatening disease. Its basic treatment is systemic steroids, after treating the first attack of the disease by systemic steroids we start to reduce the dose of the steroids gradually. During this reduction th e desease may flare up, this recurrence is routinely treated by increasing the dose of the steroids again to control the disease, this study was made to compare the benefits of tetracycline in controlling the recurrence of pemphigus vulgaris with the routinely used way which is elevating the dose of prednisolone.
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