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Register a new userThe effect of magnesium sulphate with salbutamol in the treatment of acute asthma attack
تأثير سلفات المغنزيوم مع السّالبوتامول في علاج النَّوبة الرَّبوية الحادة
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Tishreen University ورقة بحثية
Publication date
2018
fields
Medicine
and research's language is
العربية
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Shamra Editor
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تتراوح النّوبة الرّبوية الحادة من خفيفة إلى مُهدِّدة للحياة, و يُعدّ سلفات المغنزيوم أحد العلاجات المقترحة في تدبير النّوبة الرّبوية الحادة, و في حين تمَّ إثبات فعاليته بالطَّريق الوريدي, لازالت المعلومات المتوفرة عن دوره بالطَّريق الإنشاقي قليلة و متضاربة, لذا هدفت الدّراسة إلى البحث عن تأثير مشاركة سلفات المغنزيوم مع السّالبوتامول بالطّريق الإنشاقي في تدبير النّوبة الرّبوية الحادة. أُجريت دراسة تجربة سريرية عشوائية على 76 مريضاً, تمَّ توزيعهم على مجموعتين: تجريبية (40) مريضاً, ضابطة (36) مريضاً, حيث تلقت التّجريبية ارذاذ سالبوتامول مع سلفات المغنزيوم و الضابطة ارذاذ سالبوتامول مع السيروم الملحي 0,9% على ثلاث جلسات بفاصل 20 دقيقة, تم َّ تقييم علامات الشِّدة التَّنفسية, الأزيز, عدد مرات التنفس, النبض, Sao2وPEF. أظهر سلفات المغنزيوم تأثير ملحوظ في تحسين عدد مرات التنفس, Sao2وPEF بدءاً من الدقيقة 20, حيث كانت P<0,05 , و لكن لم نلاحظ وجود تأثير لسلفات المغنزيوم على علامات الشّدة التنفسية, الأزيز والنبض فكانت P>0,05, كما أنّه لم نلحظ وجود آثار جانبية تُعزى إلى سلفات المغنزيوم, و بالتالي ننصح بإضافة سلفات المغنزيوم إلى السّالبوتامول بالطّريق الإنشاقي في علاج النّوبة الرّبوية الحادة.
Asthma exacerbations can be frequent and range in severity from relatively mild to status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the informations available on its inhaled role still low and conflicting, so the study aim to investigate the effect of thecombinationof MgSO4and salbutamol in the management of acute asthma attack. A randomized clinical trial was conducted on 76 patients, divided into two groups: experimental (40) and control (36) patients. The trial received nebulised salbutamol with magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse, Sao2 and PEF were assessed. Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2 and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4 in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with salbutamol, appears to have benefits in the treatment of acute asthma attack.
References used
Syed Shahzad Mustafa, MD .Asthma. August 4, 2015. <http://www. Medicinenet.com >5-Centers for Disease Control and Prevention: National Center for Health Statistics, National Health Interview Survey Raw Data, 2011. Analysis by the American Lung Association Research and Health Education Division using SPSS and SUDAAN software
Centers for Disease Control and Prevention. Most Recent Asthma Data.http://www.cdc.gov/asthma/most_recent_data.htm.(RetrievedAugust18- 2017)
OOrtiz-Alvarez, A Mikrogianakis . Managing the paediatric patient with an acute asthma exacerbation . Paediatr Child Health 2012;17(5):251-5
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This study was done to determine whether use of nebulized salbutamol therapy for
treatment of an acute attack of asthma in children is associated with hypokalaemia and if
so what is its frequency, severity and what is accompanying clinical symptoms
103 child,
aged 3 years to 14 years with asthma attack, treated with three doses of nebulized
salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium
was obtained at the beginning and after three doses of nebulized salbutamol therapy.The
mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A
decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild
hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate
hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was
accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15,
headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate
hypokalemia.
COPD is a major public health problem , and it results with an extensive social and
economical burden on both the patient and his family on one hand and the healthcare
system on the other . Despite the great advances in the management of patients w
ith COPD
, the use of the optimal treatment of the proposed treatment options is still being discussed ,
and Must achieve greater benefit for both patients and the healthcare system .
This research is designed to study and compare the effect of the combination
(salbutamol and ipratropium bromide) with the effect of salbutamol alone in the treatment
of patients with stable COPD , by studying and comparing the improvement in the forced
expiratory volume in the first second (FEV1) and in forced vital capacity
( FVC) after a month of a treatment .
The study included 80 patients (53 males and 27 females), the patients were between
45-81 years of age , 63 patients were smokers and 17 were nonsmokers.
The study showed that after a month on therapy , for patients treated with the
combination (salbutamol + ipratropium bromide) the increasing in FEV1 was 0.35 liters
and in FVC was 0.61-liter , while , for the patients treated with salbutamol alone , the
increasing in FEV1 was 0.28 liters and FVC was 0.48-liter .
We concluded that a combination of ipratropium bromide and salbutamol is more
effective at improving pulmonary function than salbutamol alone.
Objective: Many children experience acute asthma exacerbations ,Many children
also require hospitalization despite treatment in an emergency department with current
standard therapy (corticosteroids ,and inhaled salbutamol). These hospitalizations
may be
avoided if effective adjunctive therapies can be developed to adequately treat severe
exacerbations.
the research performed by the ITP study group in 2006[15] studying the efficacy
of single dose IV-Rhesus antibodies (Anti-D) "50 ug/kg or 75 ug/kg" compared to the single dose IVIG
"800 mg/kg"; that study revealed that both have a similar therapeutic effect. that study suggest to compare the single high dose of Anti-D withthree consecutive doses of Methyl-prednisolone in respect of:
1- Time of platelet recovery
2- The continuity of mediation effect throughout ( 6 months)
3- Side effects, hospitalization and cost.
This study aimed to determine the effect of antifungal drug (copper
Sulphate) on blood picture of broiler chickens Vaccinated with
Newcastle Disease Vaccine, We used the drug being tested by two
doses: (50, 100) ppm from the age of 7 till 45 Days.
We used /150/
chick were divided into three equal groups.
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