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Register a new userInvestigate Expression some Angiogenesis Proteins in Keratocystic Odontogenic Tumour and Dentigerous Cyst
تحري تعبيرية بعض عوامل التنشؤ الوعائي في الورم الكيسي المتقرن سني المنشأ و الكيس التاجي
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Aِl-Baath University ورقة بحثية
Publication date
2017
fields
Dentistry
and research's language is
العربية
Created by
Shamra Editor
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إن الآفات سنية المنشأ الحميدة و التي تنشأ عن بقايا الصفيحة السنية الموجودة ضمن الفكين شديدة الأهمية لدى الباحثين و ذلك نظرا لتكرار معدلات النكس و الغزو فيها. يعتبر التنشؤ الوعائي خطوة رئيسة في تطور و نمو الأورام.
Objective and Aim of the study: The benign lesions of benign origin originating from the remnants of the dental lamina within the jaws are very important to the researchers because of the recurrence and inversion rates. Angiogenesis is a major step in the development and growth of tumours.
References used
Madras, J. and H. Lapointe, Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. J Can Dent Assoc, 2008. 74(2): p. 165-165h
Stoelinga, P.J., Etiology and pathogenesis of keratocysts. Oral Maxillofac Surg Clin North Am, 2003. 15(3): p. 317-24
Cakur, B., et al., Keratocystic odontogenic tumor invading the right maxillary sinus: a case report. J Oral Sci, 2008. 50(3): p. 345-9
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Amelogenins are the major enamel proteins that play a major role
in the biomineralization and structural organization of enamel ,
Aberrations of enamrl-related proteins are thought to be involved in
oncogenesis of odontogenic epithelium. The expre
ssion of
amelogenin is possibly an indicator of differentiation of epithelial
cells in the odontogenic lesions.
Aim of the Study:
Investigating the effect of adding rh-BMP2 on the expression of
vascular endothelial growth factor VEGF.
Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
Squamous cell carcinoma SCC is an important malignancy in
head and neck tumors , Its high stages resulting in poor survival
because of metastasis–especially lymph nodes- and secondary
tumors . lymph nodes LN have biological importance because of
their immunity role as a base of immunity defensive lines and lymphatic fluid purification, Recently chemokine receptors have been reported to be correlated with many malignancies ,In
particular CCR7.
Oral epithelial dysplasia is a precancerous change develops in the oral mucosa, and
leukoplakia is the most common precancerous lesions in oral mucosa.
The epithelial-mesenchymal transition (EMT) is considered the mechanism through
which the oral
leukoplakia becomes malignant, and it's also responsible for the invasion
and metastasis of cancers. This study investigates the expression of β-catenin in epithelialmesenchymal
transition detected by immunohistochemical staining in the different grades
of oral epithelial dysplasia.
The sample consisted of 45 formalin-fixed, paraffin-embedded specimens of oral
leukoplakia with different grades of oral epithelial dysplasia; specimenswere
immunohistochemically stained with β-catenin antibody.
The control group was consisted of biopsies from the normal oral epithelia.
The EMT rates are associated with the severity of the oral epithelial dysplasia.That
means, the epithelial-mesenchymal transition marker β-catenin could be used to evaluate
the potentiality of malignant transformation in the precancerous lesions.
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