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Register a new userInvestigating the effects of rh-BMP2 on the expression of Vascular Endothelial Growth Factor marker in the human bone tissue
دراسة تأثير بروتين rh-BMP2 على تعبيرية واسم عامل التنشؤ الوعائي البطاني في النسيج العظمي عند البشر
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Aِl-Baath University ورقة بحثية
Publication date
2018
fields
Dentistry
and research's language is
العربية
Authors
غسان بسيط( باحث )
Created by
Shamra Editor
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هدف البحث : إلى تحري وجود تأثير لإضافة بروتين rh-BMP2 على تعبيرية عامل التنشؤ الوعائي البطاني VEGFُ.
Aim of the Study: Investigating the effect of adding rh-BMP2 on the expression of vascular endothelial growth factor VEGF.
References used
Reddi, A.H. and A. Reddi, Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev, 2009. 20(5-6): p. 341-2
Nana, A.W., P.M. Yang, and H.Y. Lin, Overview of Transforming Growth Factor beta Superfamily Involvement in Glioblastoma Initiation and Progression. Asian Pac J Cancer Prev, 2015. 16(16): p. 6813-23
Peng, J., et al., The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-a potential therapeutic target. Mol Carcinog, 2015
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:Bone morphogenetic proteins (BMPs) belong to the
family of transforming growth factors-β (TGF-β) and play an
essential role in the cellular proliferation and differentiation. Trails
that used immunohistochemistry have shown that Ki67 is existed i
n
all normal cells which is in proliferating phase and absent in
differentiated cells in resting phase.
Aim : to investigate the effects of rhBMP-2 on the proliferative
activity of rabbits bone tissue using Ki67 staining.
Recombinant human bone morphogenetic protein-2 (rhBMP-2 ) is
effectively to regenerate defects of the maxillary and mandible
bones. Such defects are sometimes caused by resection of oral
squamous cell carcinoma (OSCC) yet the biologic effects of
rhBMP-2 on this malignancy and its histological relations and the
ability of invasion and metastasis are not fully clear.
Aim of the study : this study aimed to investigate the effects of
rhBMP2 on E-cadherin expression , which plays a pivotal role in the
cellular adhesion through the adherent junctions.
Objective and Aim of the study: The benign lesions of benign origin
originating from the remnants of the dental lamina within the jaws are very
important to the researchers because of the recurrence and inversion rates.
Angiogenesis is a major step in the development and growth of tumours.
Background and Objective : Bone morphogenic protine-2 (BMP-2) plays an essential
role in mesenchymal cells differentiation into osteoblasts، through many intracellular
pathways which crosses with tumoral pathways . Oral squamous cell carcinoma is a
n
invasive epithelial neoplasm، counts more than 90% of head and neck malignancies. It is
classified into three degrees according to the epithelial cells differentiation. The study
aimed to investigate the changes in BMP-2 expression according to the histological
degrees of the tumor.
Materials and methods : In the present study، BMP-2 expression was compared
immunohistochemically among oral squamous cell carcinoma in 27 cases (19 male+8
female) ranging between (22-74) years، mean age of (48) years. Patients have been divided
into 3 groups (each contain 9 case) according to the histological grade.
Results : By analyzing the statistical results, No significant correlation between
BMP-2 expression and the histological grad was observed. The severity of expression was
not affected by the tumour degree. Changes in membranous localization and intense
cytoplasmic staining were also not observed.
Conclusion : according to this study BMP-2 does not represent a prognostic marker
for the histological grade of oral squamous cell carcinoma.
Oral epithelial dysplasia is a precancerous change develops in the oral mucosa, and
leukoplakia is the most common precancerous lesions in oral mucosa.
The epithelial-mesenchymal transition (EMT) is considered the mechanism through
which the oral
leukoplakia becomes malignant, and it's also responsible for the invasion
and metastasis of cancers. This study investigates the expression of β-catenin in epithelialmesenchymal
transition detected by immunohistochemical staining in the different grades
of oral epithelial dysplasia.
The sample consisted of 45 formalin-fixed, paraffin-embedded specimens of oral
leukoplakia with different grades of oral epithelial dysplasia; specimenswere
immunohistochemically stained with β-catenin antibody.
The control group was consisted of biopsies from the normal oral epithelia.
The EMT rates are associated with the severity of the oral epithelial dysplasia.That
means, the epithelial-mesenchymal transition marker β-catenin could be used to evaluate
the potentiality of malignant transformation in the precancerous lesions.
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