Investigation The Expression of Chemokine Receptor CXCR4 in Head and Neck Squamous Cell Carcinoma-metastiatic lymph Nodes and Compare It with its Primary Tumor (clinical immunohistochemistry study)

this study Aimes to Investigate CXCR4 expression in primary head and neck squamous cell carcinomas tumors in all clinical stages and histological grades, then compare it with control normal oral epithelial tissues. Compare metastatic lymph nodes CXCR4 expression with their primary HNSCC tumors at high stages which associated with metastatic lymph nodes.

Investigation The Expression of Chemokine Receptor CCR7 in Head and Neck Squamous Cell Carcinomametastiatic lymph Nodes and Compare It with its Primary Tumor (clinical immunohistochemistry study)

Squamous cell carcinoma SCC is an important malignancy in head and neck tumors , Its high stages resulting in poor survival because of metastasis–especially lymph nodes- and secondary tumors . lymph nodes LN have biological importance because of their immunity role as a base of immunity defensive lines and lymphatic fluid purification, Recently chemokine receptors have been reported to be correlated with many malignancies ,In particular CCR7.