Objective: to study and evaluate the surgical operative process in the management of
Benign Tumors and Leukoplakia in the Oral Cavity by using Laser CO2.
Materials and methods: a total of 18 patients (10 males and 8 females) with mean age
50 years
, and diagnosed with Benign tumorous Lesions or Leukoplakia on mucosa of the
oral cavity, were treated by Vaporization by using CO2 Laser in Al-Assad university
hospital. The postoperative complications were recorded within 7 days after the surgery,
and the wounds was assigned until entire healing.
Results: 8(44%) patients had week pain after 24 hour of surgery, and reduced to
2(11%) patients in the third day. Edema was seen by 8(44%) patients after 24 hour of
surgery, and reduced to 1(6%) patient in the third day.5 (28%) patients showed disturbance
within oral functions, and became 1(6%) patient in the third day. No complications were
seen after 7 days of surgery. No infection or bleeding were recorded within following
time.no statistically significant differences between Lesion kind and pain degree, and no
relationship between Pain degree and Disturbance of the Lesions. Entire healing was
satisfactory in all Wounds and no scar were seen .
Conclusion: CO2 Laser is effective method in manage and minimize the
complications during Healing process after the management of Benign Tumors and
Leukoplakia in oral cavity.
Oral epithelial dysplasia is a precancerous change develops in the oral mucosa, and
leukoplakia is the most common precancerous lesions in oral mucosa.
The epithelial-mesenchymal transition (EMT) is considered the mechanism through
which the oral
leukoplakia becomes malignant, and it's also responsible for the invasion
and metastasis of cancers. This study investigates the expression of β-catenin in epithelialmesenchymal
transition detected by immunohistochemical staining in the different grades
of oral epithelial dysplasia.
The sample consisted of 45 formalin-fixed, paraffin-embedded specimens of oral
leukoplakia with different grades of oral epithelial dysplasia; specimenswere
immunohistochemically stained with β-catenin antibody.
The control group was consisted of biopsies from the normal oral epithelia.
The EMT rates are associated with the severity of the oral epithelial dysplasia.That
means, the epithelial-mesenchymal transition marker β-catenin could be used to evaluate
the potentiality of malignant transformation in the precancerous lesions.
