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Register a new userInvestigation The Expression of Chemokine Receptor CCR7 in Head and Neck Squamous Cell Carcinomametastiatic lymph Nodes and Compare It with its Primary Tumor (clinical immunohistochemistry study)
تحري تعبيرية المستقبل الكيموكيني CCR7 في النقائل العقدية للسرطان شائك الخلايا في الرأس و العنق و مقارنتها مع ورمها الأولي (دراسة سريرية كيميانسيجية مناعية)
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يعد السرطان شائك الخلايا من أهم سرطانات الرأس و العنق و يكون انذار درجاته السريرية ً العالية سيئا بسبب انتشار الخلايا السرطانية إلى أعضاء أخرى - منها العقد اللمفية - بعيدا عن مكان نشوئها الأصلي و تنشؤ أورام ثانوية على حسابها ، للنقائل العقدية أهمية بالغة لأن للعقد أهمية بيولوجية في كونها مركز للخطوط الدفاعية المناعية و لدورها في تنقية اللمف.
Squamous cell carcinoma SCC is an important malignancy in head and neck tumors , Its high stages resulting in poor survival because of metastasis–especially lymph nodes- and secondary tumors . lymph nodes LN have biological importance because of their immunity role as a base of immunity defensive lines and lymphatic fluid purification, Recently chemokine receptors have been reported to be correlated with many malignancies ,In particular CCR7.
References used
ARNOLD, C. N., CAMPBELL, D. J., LIPP, M. & BUTCHER, E. C. 2007. The germinal center response is impaired in the absence of T cellexpressed CXCR5. European journal of immunology, 37, 100-109
ASTARITA, J. L., ACTON, S. E. & TURLEY, S. J. 2012. Podoplanin: emerging functions in development, the immune system, and cancer. Frontiers in immunology, 3, 283
BAJENOFF, M., EGEN, J. G., KOO, L. Y., LAUGIER, J. P., BRAU, F., GLAICHENHAUS, N. & GERMAIN, R. N. 2006. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity, 25, 989-1001
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this study Aimes to Investigate CXCR4 expression in primary head
and neck squamous cell carcinomas tumors in all clinical stages and
histological grades, then compare it with control normal oral
epithelial tissues.
Compare metastatic lymph nodes
CXCR4 expression with their
primary HNSCC tumors at high stages which associated with
metastatic lymph nodes.
The protein p53 is the guardian of the cell gene contents from changes, and the
gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell
carcinoma’s cases producing defective protein .Studies have not detailed the
expression ratio of the
defective protein Within the cancer cells, also studies have less details about the cases which did not show
a mutated protein.
Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
Cancer of the lip is relatively common malignancy of the head and neck region.
Squamous cell carcinoma most frequently occurs in the lower lip (LLSCC) or Lower Lip Squamous Cell
Carcinoma. This study aimed to evaluate the correlation between the in
volved lymph nodes level and the
tumor appearance, greatest dimension (T) and its degree of differentiation.
This retrospective study is to correlate oral squamous cell carcinoma with age,
gender and location of lesion, and to investigate the correlation between the grade of the malignancy and
lymph nodes in patients of the faculty of dentistry, Damascus university.
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