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Register a new userNew Kinetic Spectrophotometric Method for Determination of Fluvastatin in Pure and Pharmaceutical Dosage Forms
طريقة طيفية ضوئية حركية جديدة لتحديد فلوفاستاتين في الحالة النقية و في المستحضرات الصيدلانية
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رغد الخليل( باحث )
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طورنا طريقة طيفية ضوئية حركية جديدة و دقيقة و صحيحة لتقدير فلوفاستاتين الصوديوم FVS في الحالة النقية و في المحافظ. تتضمن الطريقة تفاعل تزاوج تأكسدي للمركب FVS مع 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate(MBTH) بوجود Ce(IV) في وسط حمضي لتشكيل ناتج ملون يمتص عند 615 nm.
New, accurate, sensitive and reliable kinetic spectrophotometric method for the assay of fluvastatin sodium (FVS) in pure form and capsules has been developed. The method involves the oxidative coupling reaction of FVS with 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate (MBTH) in the presence of Ce(IV) in an acidic medium to form colored product with lambdamax at 615 nm.
References used
Shitara Y., Sugiyama Y., 2006–Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions, Pharmacology & Therapeutics, 112, 71–105
Jin-long Y.A.N., Xiu-ping L.U., 2006–Determination of fluvastatin sodium by differential pulse voltammetry, Journal of Chinese Clinical Medicine, 1(1), 33–36
Neves Marta M.P.S., Nouws Henri P.A., Delerue-Matos C., 2008– Direct electroanalytical determination of fluvastatin in a pharmaceutical dosage form: batch and flow analysis, Analytical letters, 41(13–15), 2794–2804
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A new, simple and sensitive kinetic spectrophotometric
method has been proposed for the determination of tropicamed
(TPC) in pure and pharmaceutical formulations. The method is
based on oxidation TPC by potassium permanganate in strong
alkaline m
edium (pH=12) to form green colored product with
absorbance maximum at 610nm.
A Simple, accurate and highly sensitive spectrophotometric method have been
developed for the rapid determination of Ofloxacine (OFX) in pure form and
pharmaceutical formulations. The visible spectrophotometric method was based on the
formation of
a Orange Yellow colored complex between the (OFX) and 2-amino-6-
nitrobenzothiazole (ANB) at pH 5.2 and 80±5 ºC in 5 min., and λmax at 440 nm. The
effects of analytical parameters on the reported system were investigated. Beer's law was
obeyed in the concentration range of 1.80-86.72 μg/mL, with a percentage relative standard
deviation not exceed ±2.54 and the molar absorptivity coefficients was 3.952×103
(L/mol.cm). Interferences of the other ingredients and excipients were not observed, the
results showed that the developed method with the accuracy and sensitivity highs.
Simple, accurate and reliable spectrophotometric method
has been developed for the quantitative determination of
Cephalosporins: Cefaclor, Cefalexin, Cefadroxil in pure and
pharmaceutical formulations. The method is based on the
determination of that in aqueous medium pH=6.45 at
25±0.5ºC.
A sensitive, simple and selective spectrofluorimetric method
has been proposed for determination Captopril (CPT) in pure form
and pharmaceutical preparations. This method depends on the
formation of complex between Captopril and Copper (II) at
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In this research two analytical methods were developed for the determination of Azelastin as raw material and in Nasal Spray formulation.
The first method was spectrophotometric while the other used the technic of HPLC The first method based on meas
uring the absorbance at λmax 284 nm .
The relationship between the absorbance and the concentration is rectilinear over the range 0.001 – 0.008 g %.
The proposed spectrophotometric method was successfully applied to the determination of Azelastin in nasal spray.
The percentage recoveries were 99.378±1 (10 duplicate readings)1
No interference was noticed from co-formulated drugs.
For the absorbance at λmax the obtained results were in good agreement with which obtained by the Pharmacopeia method.
The substance gave a good separation while the retention time was 1.467 min.
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