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Register a new userDetermination of Tropicamed by Kinetic Spectrophotometric Method in Pharmaceutical Preparations
تحديد التروبيكاميد بالطريقة الطيفية الضوئية الحركية في المستحضرات الصيدلانية
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اقترحت طريقة طيفية حركية جديدة لتحديد التروبيكاميد (TPC) في الحالة النقية و في المستحضرات الصيدلانية. اعتمدت الطريقة على أكسدة (TPC) بواسطة برمنغنات البوتاسيوم في وسط قلوي قوي من هيدروكسيد الصوديوم عند القيمة (pH=12), لتشكيل ناتج تفاعل أخضر اللون يملك قمة امتصاص عظمى عند nm610 عند درجة الحرارة 25±0.5 ºC.
A new, simple and sensitive kinetic spectrophotometric method has been proposed for the determination of tropicamed (TPC) in pure and pharmaceutical formulations. The method is based on oxidation TPC by potassium permanganate in strong alkaline medium (pH=12) to form green colored product with absorbance maximum at 610nm.
References used
Hardman J. G., Limbird L. E., Molinoff P. B., Ruddon R. W., 1996- The Pharmacological Basis of Therapeutics, Goodman and Gilman's, 9th edition, Mc Graw-Hill, New York, 156- 7,1635
Hardman J. G., Goodman Gilman A., Limbird L. E., 2001- The pharmacological pasis of therapeutics, 10th ed. New York: Mc Graw-Hill, 1673-1685
Delgabo J. N., Remers (editors.), W. A., 2004- Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry, 10th ed. New York: Lippincott-Raven Publ, 585
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