تمت مفاعلة مشتقات الفينول مع هاليدات الأريل في وسط قلوي غير متجانس
(أمبرلست- 21) بوجود % 5 مول من معقد النحاس (I) ذو الصيغة [CuClPPh3]4.
حيث أجري تفاعل بارا كريزول مع برومو البنزن كتفاعل نموذجي، استخدم في هذا
التفاعل كمحل أورتو كزايلين و الذي لا ينحل فيه المعقد لذا فيه يدخل في الوساطة بشكل
غير متجانس و يرشح في نهاية التفاعل ليدخل عدة مرات في تفاعلات لاحقة، وفقاً لهذه
الشروط حضرت مركبات جديدة بتفاعل أحد مشتقات برومو الأريل مع باراسيتامول،
المركبات المحضرة يتوقع أن يكون لها تطبيقات صيدلانية كمضادات التهاب غير
ستيروئيدية و تم إثبات بنى المركبات المحضرة باستخدام مطيافيات NMR و IR .
Phenol derivatives have been reacted with aryl halides under
heterogeneous basic catalyst (Amberlyst-21) using 5 mol% Cu(I)
Complex as catalyst, [CuClPPh3]4. The typical reaction has been
performed between p-cresol and bromobenzene. This reaction is
achieved in o-xylene as solvent. However, the catalyst complex
does not dissolve in toluene rather it acts as heterogeneous catalyst.
Therefore, it is filtrated at the end of the reaction and reused several
times. Accordingly, new compounds were prepared by reacting one
of the bromoaryl derivatives with paracetamol. It is anticipated that
the synthesized compounds may have pharmaceutical application as
non-steroidial anti-inflammatory drugs (NSAIDs).
References used
D. C. Atkinson, K. E. Godfrey, B. J. Jordan, E. C. Leach, B. Meek, J. D. Nichols and J. F. Saville, (1974) 2-(2,4- Dichlorophenoxy) phenylacetic acid (fenclofenac): one of a novel series of anti-inflammatory compounds with low ulcerogenic potential, V.26, P.357-359
NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. ED McNicol, S Strassels, L Goudas, J Lau… - The Cochrane …, 2015 - Wiley Online Library
The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation EM Spiers, NT Watson, JS Beck, IV Chapman… - International journal of …, 1993 – Elsevier
The Reaction of Glycerol carried out with tow aryl halides
under basic conditions (K2CO3) using 5 mol% of Pd(II)Complex as
catalyst, Pd(PPh3)2Cl2. The typical reaction has been performed
between glycerol and bromobenzene. This reaction is achieved
Two ethers coumarin derivatives: 7-phenoxy -4-carboxylic
coumarin (B) and 7- (6,2-di-chloro) -4-carboxylic coumarin (C)
have been synthesized from the 7-hydroxy-4-methy coumarin
(A) as beginning compound and the copper complex [CuPPh3Cl]4
carried on the amberlyst-21 as the eco-friendly catalyst, these ethers
coumarin derivatives have an important biological properties may
be used in the treatment of breast cancer.
The history of medicine using medicinal plants goes back thousands of years, and according to the reports of the World Health Organization, many of the world's people mainly use the plant to treat many diseases, and one of the plants that is famous for its widespread use is the leaves of Ginkgo biloba.
During this study, various types of silicon oxide were prepared
as aerogel and xerogel using multiple precursors and different
drying technics. Some of these samples were prepared from
Sodium silicate (waterglass) Na2SiO3 as a precursor which is a
Radar detects the targets and measures its parameters, range,
azimuth, height, and velocity of the target.
In some application, such as early warning radar we don’t
have extremely measure all these parameters, but in other
application like detect