The Reaction of Glycerol carried out with tow aryl halides
under basic conditions (K2CO3) using 5 mol% of Pd(II)Complex as
catalyst, Pd(PPh3)2Cl2. The typical reaction has been performed
between glycerol and bromobenzene. This reaction is achieved
in
water as solvent. However, the catalyst complex does not dissolve
in aqueous solutions rather it acts as heterogeneous catalyst.
Therefore, it is filtrated at the end of the reaction and reused several
times. Accordingly, new compound were prepared by reacting
glycerol with 1-bromo-2,6-dichlorobenzene. It is anticipated that the
synthesized compounds may have pharmaceutical application.
Phenol derivatives have been reacted with aryl halides under
heterogeneous basic catalyst (Amberlyst-21) using 5 mol% Cu(I)
Complex as catalyst, [CuClPPh3]4. The typical reaction has been
performed between p-cresol and bromobenzene. This reaction
is
achieved in o-xylene as solvent. However, the catalyst complex
does not dissolve in toluene rather it acts as heterogeneous catalyst.
Therefore, it is filtrated at the end of the reaction and reused several
times. Accordingly, new compounds were prepared by reacting one
of the bromoaryl derivatives with paracetamol. It is anticipated that
the synthesized compounds may have pharmaceutical application as
non-steroidial anti-inflammatory drugs (NSAIDs).
Two ethers coumarin derivatives: 7-phenoxy -4-carboxylic
coumarin (B) and 7- (6,2-di-chloro) -4-carboxylic coumarin (C)
have been synthesized from the 7-hydroxy-4-methy coumarin
(A) as beginning compound and the copper complex [CuPPh3Cl]4
carried on the amberlyst-21 as the eco-friendly catalyst, these ethers
coumarin derivatives have an important biological properties may
be used in the treatment of breast cancer.
