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Register a new userStudy of optic nerve head (ONH) and intra-ocular pressure (IOP) in pseudoexfoliation syndrome (PXS) patients Thesis prepared to get master’s degree in ophthalmology
" دراسة القرص البصري و ضغط العين عند مرضى متلازمة التقشر الكاذب "
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الهدف: دراسة انتشار الأذيات الزرقية لدى مرضى التوسف الكاذب , و دراسة قيم ضغط العين لديهم و علاقتها مع هذه الأذيات. الطرائق: تمت دراسة 75 عيناً مصابة بالتوسف الكاذب و مقارنتها مع 75 عيناً طبيعية لمرضى مقاربين في العمر, كما شملت دراسة 21 مريضاً لديهم توسف سريري بعين واحدة و تمت مقارنة العينين , و شملت المقارنة دراسة العصب البصري بجهاز HRT) Heidelberg Retina Tomograph) و قياس ضغط العين الوسطي و مقدار تأرجحه. النتائج: قياسات العصب البصري التي تمت مقارنتها شملت: مساحة العصب, مساحة الحافة العصبية الشبكية, مساحة القرص, سماكة طبقة الألياف العصبية حول الحليمة, نسبة التقعر العمودي إلى القرص, نتيجة تحليل (Moorfields Regression Analysis (MRA, و نتيجة تحليل GPS) Glaucoma Probability Score). و كان الفرق هاماً إحصائياً في جميع هذه النتائج بين المرضى و الشواهد, كما كان الفرق هاماً في وسطي ضغط العين و مقدار تأرجحه. أما لدى المرضى المصابين بعين واحدة فكانت قياسات العصب البصري متقاربة دون فروق هامة, و لكن الفرق كان هاماً في وسطي و تأرجح ضغط العين. الخلاصة: العيون المصابة بالتوسف الكاذب ذات خطورة عالية لحدوث أذية زرقية في العصب البصري و يزداد احتمال هذه الأذية بزيادة ضغط العين و تأرجحه, كما تشمل الخطورة العين الأخرى السليمة في الإصابة أحادية الجانب, ما يؤكد أن التوسف الكاذب مرض جهازي ذو تظاهرات عينية.
Aim: to study the prevalence of glaucomatous injury in pseudoexfoliation patients, and the relation of these injuries with IOP values. Methods: 75 PXS eyes were compared with 75 age matched control eyes, and so 21 unilateral PXS patients were studied by comparing their two eyes. The study contained ONH study with Heidelberg Retina Tomograph (HRT), and mean and range of IOP values. Results: ONH parameters which were compared between patients and controls included: disk area, rim area, cup area, mean RNFL thickness, vertical cup\disk ratio, MRA result, and GPS result. The difference was significant in all these parameters between patients and controls, also it was significant in mean IOP and its fluctuation. For unilateral PXS patients, no statistically significant difference was found in ONH parameters between the two eyes, but there was in IOP mean and range. Conclusion: PXS eyes are at high risk for developing glaucomatous optic nerve injuries, which were more probable with raised IOP mean and range; the risk also involved the other normal eye in unilateral PXS, certaining the systemating nature of pseudo exfoliation disease.
References used
KOLIAKOS GG, KONSTAS AG, SCHLÖTZER-SCHREHARDT U, et al. 8-Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol. 87(3): 2003; 353–356
ROTH M, EPSTEIN DL. Exfoliation syndrome. Am J Ophthalmol. 89(4): 1980; 477–481
MANISHI A. DESAI, MD AND RICHARD K. LEE, MD, PHD. The Medical and Surgical Management of Pseudoexfoliation Glaucoma. Int Ophthalmol Clin. 48(4): 2008 ; 95–113
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Purpose: to study the Distribution of intraocular pressure in the age group 20-40 years old and the related factors: age, gender, family history, BMI, smoking.
Methods: This was a population-based cross-sectional study of 1000 subjects All particip
ant underwent IOP (intraocular pressure) measurement and a standardized survey for the initial data of the study.
Results: The mean IOP for the study subjects was (17.6mmHg); the mean IOP in men was higher than women (17.53) vs (16.8) mmHg respectively. Ocular hypertension was found in 16.8% participants. IOP increased 0.5 mmHg for every 10 years of age. BMI (Body Mass Index) had a positive association with IOP. Subjects with positive family history of ocular hypertension had higher IOP (18.46) vs (16.98) mmHg. IOP was higher in smokers’ group (17.77) vs (16.29) mmHg. Multivariate analyzing showed that aging, smoking, male sex, family history were independent risk factors for ocular hypertension, otherwise there was no significant relationship between ocular hypertension and BMI.
Hyperimmunoglobulin E (Job) syndrome is considered to be a relatively rare
disease. Its characterized by recurrent infections in skin (eg. boils, abscesses), recurrent upper respiratory
tract infections (eg. otitis media, sinusitis and mastoiditis)
, and lower respiratory infections (eg. recurrent
pneumonia, which is often complicated by pneumatoceles and lung abscess), that are usually difficult to
treat. The highly increased IgE levels are considered to be the hallmark of the disease. The syndrome has
two types: one is inherited as an autosomal recessive, and the other, as an autosomal dominant trait.
To highlight the clinical manifestations and laboratory findigs of Job disease, and to compare it with
medical literature, to study the bacterial complications and differrent types of antibacterial treatments
and treir results, and to increase the level of awareness among physicians.
Background& Objective: Selective IgA deficiency is the most common primary immunodeficiency in
humans. Its prevalence ranges from 1 in 100 to 1 in 1000 in among Arab populations. The majority of
patients with selective IgA deficiency are asymptomat
ic. The remaining present with recurrent upper and
lower respiratory tract infections, recurrent gastrointestinal infections, otitis media, sinusitis, celiac
disease, giardiasis, allergic disorders and some autoimmune diseases.
to highlight the clinical manifestations and laboratory findings of Selective IgA deficiency in our study,
and to compare it with medical literature. To study the bacterial complications and their prevalence.
Materials & Methods: A retrospective study was carried out in Damascus University Children’s Hospital
on sixteen child diagnosed as Selective IgA deficiency, in a period of the last ten years (from 2000 till
September 2010).
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medical literature. In general, the infectious complications had a good response to antibacterial therapy,
and the IgA levels became normal in one patient, when he reached the age of eleven years.
Conclusion: there is no information in medical literature about the association of selective IgA deficiency
with hepatomegaly, splenomegaly, failure to thrive and an increased prevalence of urinary tract
infections, therefore, it is necessary to conduct researches about this association.
The chronic administration of intraocular pressure –lowering eye
drops is associated with changes on the surface of the cornea and
our study aim to evaluate the corneal sensitivity in patients treated
with eye drops contain benzalkonium hydrochloride for glaucoma .
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