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Study of optic nerve head (ONH) and intra-ocular pressure (IOP) in pseudoexfoliation syndrome (PXS) patients Thesis prepared to get master’s degree in ophthalmology

" دراسة القرص البصري و ضغط العين عند مرضى متلازمة التقشر الكاذب "

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 Publication date 2016
and research's language is العربية
 Created by Shamra Editor




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Aim: to study the prevalence of glaucomatous injury in pseudoexfoliation patients, and the relation of these injuries with IOP values. Methods: 75 PXS eyes were compared with 75 age matched control eyes, and so 21 unilateral PXS patients were studied by comparing their two eyes. The study contained ONH study with Heidelberg Retina Tomograph (HRT), and mean and range of IOP values. Results: ONH parameters which were compared between patients and controls included: disk area, rim area, cup area, mean RNFL thickness, vertical cup\disk ratio, MRA result, and GPS result. The difference was significant in all these parameters between patients and controls, also it was significant in mean IOP and its fluctuation. For unilateral PXS patients, no statistically significant difference was found in ONH parameters between the two eyes, but there was in IOP mean and range. Conclusion: PXS eyes are at high risk for developing glaucomatous optic nerve injuries, which were more probable with raised IOP mean and range; the risk also involved the other normal eye in unilateral PXS, certaining the systemating nature of pseudo exfoliation disease.


Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى تحليل انتشار الأذيات الزرقية لدى مرضى متلازمة التقشر الكاذب ودراسة قيم ضغط العين لديهم وعلاقتها بهذه الأذيات. شملت الدراسة 75 عيناً مصابة بالتقشر الكاذب و 75 عيناً طبيعية للمقارنة، بالإضافة إلى 21 مريضاً لديهم تقشر سريري في عين واحدة. تم استخدام جهاز Heidelberg Retina Tomograph (HRT) لدراسة العصب البصري وقياس ضغط العين. أظهرت النتائج فروقاً هامة إحصائياً بين المرضى والشواهد في جميع قياسات العصب البصري وضغط العين، مما يشير إلى أن العيون المصابة بالتقشر الكاذب ذات خطورة عالية لتطوير أذيات زرقية. كما أكدت الدراسة أن التقشر الكاذب مرض جهازي ذو تظاهرات عينية، وأن ضغط العين وتأرجحه يلعبان دوراً هاماً في زيادة خطورة الأذيات الزرقية.
Critical review
دراسة نقدية: تعتبر هذه الدراسة ذات أهمية كبيرة في فهم العلاقة بين متلازمة التقشر الكاذب والأذيات الزرقية. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين عدد أكبر من المرضى لتحسين قوة النتائج الإحصائية. ثانياً، لم يتم استخدام اختبارات إضافية مثل الساحة البصرية لتأكيد وجود الأذيات الزرقية، مما قد يؤثر على دقة النتائج. وأخيراً، كان من الممكن توسيع الدراسة لتشمل تأثير العلاجات المختلفة على ضغط العين والأذيات الزرقية لدى المرضى. بشكل عام، تعتبر الدراسة خطوة هامة في هذا المجال ولكنها تحتاج إلى مزيد من البحث لتأكيد النتائج وتوسيعها.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تحليل انتشار الأذيات الزرقية لدى مرضى متلازمة التقشر الكاذب ودراسة قيم ضغط العين لديهم وعلاقتها بهذه الأذيات.

  2. ما هي الأدوات المستخدمة في الدراسة لقياس العصب البصري وضغط العين؟

    تم استخدام جهاز Heidelberg Retina Tomograph (HRT) لدراسة العصب البصري وجهاز النفخة الهوائية لقياس ضغط العين.

  3. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    أظهرت النتائج فروقاً هامة إحصائياً بين المرضى والشواهد في جميع قياسات العصب البصري وضغط العين، مما يشير إلى أن العيون المصابة بالتقشر الكاذب ذات خطورة عالية لتطوير أذيات زرقية.

  4. ما هي التوصيات التي قدمتها الدراسة بناءً على النتائج؟

    أوصت الدراسة باعتبار التقشر الكاذب عامل عالي الخطورة لحدوث الزرق، وضرورة قياس ضغط العينين وإجراء ساحة بصرية وطبوغرافيا للقرص البصري وتخانة الألياف العصبية حول الحليمة لكل مريض توسف كاذب، بالإضافة إلى مراقبة دورية لهؤلاء المرضى.


References used
KOLIAKOS GG, KONSTAS AG, SCHLÖTZER-SCHREHARDT U, et al. 8-Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol. 87(3): 2003; 353–356
ROTH M, EPSTEIN DL. Exfoliation syndrome. Am J Ophthalmol. 89(4): 1980; 477–481
MANISHI A. DESAI, MD AND RICHARD K. LEE, MD, PHD. The Medical and Surgical Management of Pseudoexfoliation Glaucoma. Int Ophthalmol Clin. 48(4): 2008 ; 95–113
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