Hyperimmunoglobulin E (Job) syndrome is considered to be a relatively rare
disease. Its characterized by recurrent infections in skin (eg. boils, abscesses), recurrent upper respiratory
tract infections (eg. otitis media, sinusitis and mastoiditis)
, and lower respiratory infections (eg. recurrent
pneumonia, which is often complicated by pneumatoceles and lung abscess), that are usually difficult to
treat. The highly increased IgE levels are considered to be the hallmark of the disease. The syndrome has
two types: one is inherited as an autosomal recessive, and the other, as an autosomal dominant trait.
To highlight the clinical manifestations and laboratory findigs of Job disease, and to compare it with
medical literature, to study the bacterial complications and differrent types of antibacterial treatments
and treir results, and to increase the level of awareness among physicians.
