Study of optic nerve head (ONH) and intra-ocular pressure (IOP) in pseudoexfoliation syndrome (PXS) patients Thesis prepared to get master’s degree in ophthalmology

Aim: to study the prevalence of glaucomatous injury in pseudoexfoliation patients, and the relation of these injuries with IOP values. Methods: 75 PXS eyes were compared with 75 age matched control eyes, and so 21 unilateral PXS patients were studied by comparing their two eyes. The study contained ONH study with Heidelberg Retina Tomograph (HRT), and mean and range of IOP values. Results: ONH parameters which were compared between patients and controls included: disk area, rim area, cup area, mean RNFL thickness, vertical cup\disk ratio, MRA result, and GPS result. The difference was significant in all these parameters between patients and controls, also it was significant in mean IOP and its fluctuation. For unilateral PXS patients, no statistically significant difference was found in ONH parameters between the two eyes, but there was in IOP mean and range. Conclusion: PXS eyes are at high risk for developing glaucomatous optic nerve injuries, which were more probable with raised IOP mean and range; the risk also involved the other normal eye in unilateral PXS, certaining the systemating nature of pseudo exfoliation disease.

Distribution of intraocular pressure in the age group 20-40 years old and the related factors

Purpose: to study the Distribution of intraocular pressure in the age group 20-40 years old and the related factors: age, gender, family history, BMI, smoking. Methods: This was a population-based cross-sectional study of 1000 subjects All participant underwent IOP (intraocular pressure) measurement and a standardized survey for the initial data of the study. Results: The mean IOP for the study subjects was (17.6mmHg); the mean IOP in men was higher than women (17.53) vs (16.8) mmHg respectively. Ocular hypertension was found in 16.8% participants. IOP increased 0.5 mmHg for every 10 years of age. BMI (Body Mass Index) had a positive association with IOP. Subjects with positive family history of ocular hypertension had higher IOP (18.46) vs (16.98) mmHg. IOP was higher in smokers’ group (17.77) vs (16.29) mmHg. Multivariate analyzing showed that aging, smoking, male sex, family history were independent risk factors for ocular hypertension, otherwise there was no significant relationship between ocular hypertension and BMI.