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Register a new userStudy of the Long Term Stability of Butrylcholinesterase and its Dependence on Sex and Age
دراسة ثبوتية فعالية انزيم كولين استراز مصل الدم و تابعيتها للجنس و العمر
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Damascus University ورقة بحثية
Publication date
2001
fields
Chemistry
and research's language is
العربية
Created by
Shamra Editor
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درست فعالية أنزيم كولين أستراز مصل الدم في ١٦٨ عينة من الذكور ( ٨٠ ) و الإناث ( ٨٨ ) تتراوح أعمارهم بين ١٨-٧٨ عامًا . قيست فعالية الأنزيم في عينة المصل مباشرة و في الأجزاء التي حفظت في الدرجة ٤+ °C و في الدرجة -٢٠°C . أظهرت نتائج البحث تشابهًا في قيم الفعالية في كافة الشروط المدروسة. و تبين لدى دراسة تأثير الجنس على فعالية الأنزيم أنها لدى الذكور أعلى منها لدى الإناث. و قد بدا ذلك واضحًا لدى الذكور الذين تتراوح أعمارهم بين ١٨ و ٥٠ عامًا. كما ازدادت فعالية الأنزيم لدى الإناث اللواتي تزيد أعمارهن عن ال ٥٠ عامًا مقابل الإناث اللواتي أعمارهن أقل، كما لم يظهر أي تغير في فعالية الأنزيم المأخوذ من الذكور .
Specimens of serum from ١٦٨ healthy subjects (٨٠ men and ٨٨ women, ages ١٨ to ٧٨ years)were divided into three groups: fresh, storage at ٤°C, and freezing at-٢٠°C . Periodic essays for the activity of Butrylcholinesterase (BChE,EC. ٣٫١٫١٫٨) were made on each frozen and unfrozen specimen. Serum frozen at-٢٠°C and left at ٤°C gave results similar to those from fresh specimens. Comparison of samples from men and women revealed significantly higher activity in men than in women (P<٠٫٠٠١). Activity was greatest in men aged ١٨-٥٠ years and then declined to slightly lower values. In women the activity was less in those under ٥٠ years old than in those above ٥٠.
Artificial intelligence review:
Research summary
تدرس هذه الورقة البحثية الاستقرار طويل الأمد لإنزيم بوتيريل كولينستراز (BChE) وتأثير الجنس والعمر على نشاطه. تم جمع عينات مصل الدم من متبرعين أصحاء (رجال ونساء) تتراوح أعمارهم بين 14 و 54 عامًا، وتم تقسيم العينات إلى ثلاث مجموعات: طازجة، مخزنة عند 4 درجات مئوية، ومجمدة عند -20 درجة مئوية. أظهرت النتائج أن نشاط BChE كان أعلى بشكل ملحوظ في الرجال مقارنة بالنساء، وكان النشاط الأكبر في الرجال الذين تتراوح أعمارهم بين 14 و 34 عامًا، ثم انخفض قليلاً. في النساء، كان النشاط أقل في الفئة العمرية الأقل من 40 عامًا مقارنة بالفئة العمرية الأكبر. أظهرت الدراسة أيضًا أن الإنزيم يحتفظ بنشاطه بشكل جيد عند التخزين في درجات حرارة مختلفة، مما يجعله مفيدًا في التشخيص السريري وتقييم حالات التسمم بالمبيدات الحشرية العضوية الفوسفورية.
Critical review
دراسة نقدية: تقدم هذه الورقة البحثية معلومات قيمة حول استقرار إنزيم بوتيريل كولينستراز وتأثير الجنس والعمر على نشاطه. ومع ذلك، يمكن أن تكون هناك بعض النقاط التي تحتاج إلى مزيد من التوضيح أو التحسين. على سبيل المثال، لم يتم توضيح السبب الدقيق وراء الفروق الكبيرة في النشاط بين الجنسين بشكل كافٍ. بالإضافة إلى ذلك، يمكن أن تكون العينة المستخدمة في الدراسة أكبر وأكثر تنوعًا لضمان نتائج أكثر دقة وشمولية. كما أن الدراسة لم تتناول بشكل كافٍ تأثير العوامل البيئية الأخرى التي قد تؤثر على نشاط الإنزيم.
Questions related to the research
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ما هو الهدف الرئيسي من هذه الدراسة؟
الهدف الرئيسي هو تحديد استقرار نشاط إنزيم بوتيريل كولينستراز في العينات المجمدة وغير المجمدة وتوزيع مستويات نشاطه بين مختلف الفئات العمرية والجنسية.
-
ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟
النتائج الرئيسية هي أن نشاط BChE كان أعلى في الرجال مقارنة بالنساء، وكان النشاط الأكبر في الرجال الذين تتراوح أعمارهم بين 14 و34 عامًا، وأن الإنزيم يحتفظ بنشاطه بشكل جيد عند التخزين في درجات حرارة مختلفة.
-
ما هي الفروق في نشاط الإنزيم بين الجنسين؟
كان نشاط الإنزيم أعلى بشكل ملحوظ في الرجال مقارنة بالنساء في جميع الفئات العمرية، وكان هذا الفارق أكثر وضوحًا في الفئة العمرية الأقل من 40 عامًا.
-
كيف يمكن استخدام نتائج هذه الدراسة في التطبيقات السريرية؟
يمكن استخدام نتائج هذه الدراسة في التشخيص السريري وتقييم حالات التسمم بالمبيدات الحشرية العضوية الفوسفورية، وكذلك في متابعة تطور أمراض الكبد مثل التهاب الكبد أو تليف الكبد.
References used
Balasubramanian, A.S. and Bhanumathy, C.D. (١٩٩٣): Noncholinergic functions of cholinesterase. FASEB J, ٧, ١٣٥٤-٨
Vellom, D.C., Radic, Z., Li,Y., Pickring, N.A., Camp, S. and Tylor, P. (١٩٩٣): Amino acid residues controlling acetylcholinesterase and butrylcholinesterase specificity. Biochemistry, ٣٢, ١٢-١٧
Whittaker, V.P. (١٩٩٣): The cholinesterase: a discussion of some unanswered questions. Prg. Brain Res., ٣٢, ١٢-٧
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