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Register a new userThe efficacy of tetracycline in the treatment of the recurrency of pemphigus vulgaris occurring during the period of steroid reduction
فعالية التتراسيكلين في معالجة نكس الفقاع الشائع الحادث خلال مدة تخفيض الستيروئيد
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الفقاع الشائع مرض مهدد للحياة ناكس، علاجه الأساسي الستيروئيدات الجهازية، بعد علاج الهجمة الأولى يخفض الستيروئيد تدريجياً و خلال هذا التخفيض يمكن أن يحدث النكس، و عند حدوث النكس يعالج بشكل روتيني برفع جرعة الستيروئيد مرة أخرى من أجل السيطرة على المرض . هدفت هذه الدراسة إلى مقارنة فائدة التتراسيكلين في السيطرة على النكس، مع الأسلوب الروتيني المستخدم و هو رفع جرعة البريدنيزولون.
Pephigus vulgaris is a recurrent life threatening disease. Its basic treatment is systemic steroids, after treating the first attack of the disease by systemic steroids we start to reduce the dose of the steroids gradually. During this reduction the desease may flare up, this recurrence is routinely treated by increasing the dose of the steroids again to control the disease, this study was made to compare the benefits of tetracycline in controlling the recurrence of pemphigus vulgaris with the routinely used way which is elevating the dose of prednisolone.
References used
Chams-Davatchi C ,et al. Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris. J Am Acad Dermatol 2007 Oct;57( 4): 622-628
Gouveia C, Coutinho V, Filipe P, Cirne-de-Castro J. Morbidity and mortality from steroid therapy in pemphigus. J Am Acad Dermatol 2004 Mar: P96
Ioannides D, Chrysomallis F, Bystryn J. Ineffectiveness of Cyclosporine as an Adjuvant to Corticosteroids in the Treatment of Pemphigus. Arch Dermatol 2000;136:868-872
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Background& Objective: pemphigus vulgaris is a life threatening relapsing disease, the first line in its
treatment is systemic steroids, and due to the high rate of side effects caused by systemic steroids in
pemphigus vulgaris patients ,some immun
osuppressant drugs have been introduced as an adjuvant
steroid sparing agents , and one of these immunosuppressants is azathioprine, which is the most used drug
by therapists, but this use was due to experience and not due to strict studies , this research studies the
relationship between azathioprine and relapse in pemphigus vulgaris patients during the prednisolone
reduction period.
Materials & Methods: 70 pemphigus vulgaris patients have been studied, from the patients of the
dermatology university hospital during the period between 1/8/2008 -29/5/2011 (the first year for
collecting the sample and the rest for follow-up) they have been divided into 2 groups. The first: were
treated with prednisolone plus azathioprine (30 patients ), the second : were treated with prednisolone
alone (40 patients ).and after the control of the disease the dose of prednisolone was reduced gradually ,till
it was stopped, and patients were observed for relapse.
Results: there was no meaningful statistical difference between the two groups in the terms of relapse, as
giving azathioprine did not reduce the relapse rate, and did not reduce the prednisolone dose needed to
prevent relapse.
Conclusion: in this study no use of azathioprine in preventing relapse in pemphigus vulgaris patients, so
we advise for more studies to confirm that, and to give more attention during its prescription.
pemphigus vulgaris is a life threatening relapsing disease, the first line in its
treatment is systemic steroids, and due to the high rate of side effects caused by systemic steroids in
pemphigus vulgaris patients, some immunosuppressant drugs have
been introduced as an adjuvant
steroid sparing agents, and one of these immunosuppressants is methotrexate, and in spite of the lack of
its use in pemphigus vulgaris, a few studies have shown an encouraging results of its use, and have advised
to carry out more studies about it as an immunosuppressant which has been omitted from usage in
pemphigus vulgaris for a long time.
Experiment was conducted on 160 fertilized egg sterile, distributed
in four groups of 40 eggs in each of them, eggs incubation in the
hatchery for 12 h, and then go out and inject eggs experimental
Groups (1-2-3) with a solution of tetracycline under the embryo disk.
This research aims to reduce the possible consumption in CMOS digital circuit type and to
develop new methods in this area and get the results of a new process applicable in the
field of the development of integrated electronic devices of high inte
gration VLSI, has
been in this study the possible reduction of consumer dynamic by Reduction Of switching
Activit where the researcher changed the architecture of digital circuit on the possible
consuming, and she used different combinations of the circuit.
the researcher got good results in a manner using the Matlab simulation program where she
got reduction of 01%, which helps us to achieve high standards in the design of integrated
circuits.
Due to it`s several properties of Trypsin as an active enzyme in treating wounds, the
aim of this study was to evaluate the efficacy of this material with traditional treatments in
treating dry socket.
Methods:132 patients (20-65 years old) partic
ipated in this study.
The patient were distributed randomly into two groups.
The first group (group 1) was treated with Trypsin whereas the other (group 2) was
treated with traditional technique .
Patients were monitored, to asses healing process, after 24 hours, 48 hourse, and after
1 week.
Results: 43,9% of group 1 and 10,6% of group 2 had no pain P<0,05,wereas 81,8%
of group 1 and 43,9% of group 2 didn`t present dry socket P<0,05. Concerning infection ,7
cases of group 1 and 11 cases of group 2 had infection of soft tissue P<0,05.
Conclusions :Pain, dry socket, and soft tissue infection was less in casese treated
with Trypsin comparing with cases treated with traditional technique.
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