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The efficacy of using Trypsin in treatment of dry socket

فعالية استخدام التريبسين في علاج التهاب السنخ الجاف

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 Publication date 2015
and research's language is العربية
 Created by Shamra Editor




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Due to it`s several properties of Trypsin as an active enzyme in treating wounds, the aim of this study was to evaluate the efficacy of this material with traditional treatments in treating dry socket. Methods:132 patients (20-65 years old) participated in this study. The patient were distributed randomly into two groups. The first group (group 1) was treated with Trypsin whereas the other (group 2) was treated with traditional technique . Patients were monitored, to asses healing process, after 24 hours, 48 hourse, and after 1 week. Results: 43,9% of group 1 and 10,6% of group 2 had no pain P<0,05,wereas 81,8% of group 1 and 43,9% of group 2 didn`t present dry socket P<0,05. Concerning infection ,7 cases of group 1 and 11 cases of group 2 had infection of soft tissue P<0,05. Conclusions :Pain, dry socket, and soft tissue infection was less in casese treated with Trypsin comparing with cases treated with traditional technique.


Artificial intelligence review:
Research summary
تستعرض هذه الدراسة فعالية استخدام إنزيم التريبسين في علاج التهاب السنخ الجاف مقارنة بالطرق التقليدية. أجريت الدراسة على 132 مريضًا تتراوح أعمارهم بين 20 و65 عامًا، تم تقسيمهم عشوائيًا إلى مجموعتين: الأولى عولجت بالتريبسين والثانية بالطرق التقليدية. تم تقييم المرضى بعد 24 ساعة، 48 ساعة، وأسبوع من العلاج. أظهرت النتائج أن نسبة الألم، استمرار التهاب السنخ الجاف، وإنتان النسج المحيطة بالسنخ كانت أقل في المجموعة التي عولجت بالتريبسين مقارنة بالمجموعة التي عولجت بالطرق التقليدية. خلصت الدراسة إلى أن التريبسين يمكن أن يكون فعالًا في تقليل الألم وتسريع الشفاء في حالات التهاب السنخ الجاف.
Critical review
دراسة نقدية: على الرغم من أن الدراسة تقدم نتائج مشجعة حول فعالية التريبسين في علاج التهاب السنخ الجاف، إلا أن هناك بعض النقاط التي تحتاج إلى مزيد من التوضيح. أولاً، لم يتم توضيح تفاصيل الجرعة المستخدمة من التريبسين بشكل كافٍ، مما يجعل من الصعب تكرار الدراسة بدقة. ثانيًا، لم يتم مناقشة الآثار الجانبية المحتملة لاستخدام التريبسين بشكل كافٍ، وهو أمر مهم لضمان سلامة المرضى. ثالثًا، كان من الممكن أن تكون الدراسة أكثر شمولية إذا تم تضمين مجموعة أكبر من المرضى ومن مواقع جغرافية مختلفة للتأكد من تعميم النتائج. وأخيرًا، يجب إجراء دراسات إضافية لمقارنة التريبسين مع علاجات أخرى حديثة لضمان أنه الخيار الأمثل لعلاج التهاب السنخ الجاف.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تقييم فعالية إنزيم التريبسين في علاج التهاب السنخ الجاف مقارنة بالطرق التقليدية.

  2. كم عدد المرضى الذين شاركوا في الدراسة؟

    شارك في الدراسة 132 مريضًا تتراوح أعمارهم بين 20 و65 عامًا.

  3. ما هي النتائج الرئيسية للدراسة؟

    أظهرت النتائج أن نسبة الألم، استمرار التهاب السنخ الجاف، وإنتان النسج المحيطة بالسنخ كانت أقل في المجموعة التي عولجت بالتريبسين مقارنة بالمجموعة التي عولجت بالطرق التقليدية.

  4. ما هي التوصيات التي خلصت إليها الدراسة؟

    خلصت الدراسة إلى أن استخدام التريبسين لعلاج التهاب السنخ الجاف يعتبر من الطرق الناجحة ويجب على أطباء الأسنان أخذها بعين الاعتبار كمخفف للألم ومحسن لأداء الخلايا المرممة للمساعدة في الشفاء.


References used
ABU YOUNIS MH, ABU HANTASH RO. Dry socket: frequency, clinical picture, and risk factors in a palestinian dental teaching center. Open Dent J. 2011 Feb 7;5:7-12
RAVIKUMAR T, RAMAKRISHNAN M, JAYARAMAN V, BABU M. Effect of trypsin-chymotrypsin (Chymoral Forte D.S.) preparation on the modulation of cytokine levels in burn patientsBurns. 2001 Nov;27(7):709-16
BLUM IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002 Jun;31(3):309-17
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