Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userLow 25 Hydroxyvitamin D3 levels in healthy Syrians
نقص مستويات 25 هيدروكسي فيتامين د 3 لدى عينة من السوريين الأصحاء
1450
3 227
0
(
0
)
Created by
Shamra Editor
Ask ChatGPT about the research
يرتبط نقص فيتامين د بالإصابة بالعديد من الأمراض منها تلين العظام و الداء القلبي الوعائي و بعض الأمراض المناعية الذاتية، و قد أظهرت دراسات عدة شيوع نقصه في العديد من بلدان العالم و لاسيما المجاورة لسورية. يهدف هذا البحث إلى دراسة المستويات المصلية ل 25 هيدروكسي فيتامين د 3 لدى عينة من السوريين الأصحاء بسبب نقص المعلومات حول واقع فيتامين د في بلادنا.
Hypovitaminosis D is linked to osteomalacia , cardiovascular disease and some autoimmune diseases. Many studies showed that hypovitaminosis D is common worldwide, especially in the neighboring countries. The aim of this study is to determine serum concentrations of 25 hydroxyvitamin D3 in healthy Syrians, since vitamin D status in Syria is unknown.
References used
Gallagher M L. Vitamins. Mahan L K, Escott-Stump S. Krause`s Food, Nutrition& Diet Therapy 11TH ed :Saunders ,2004. 83-88
Bringhurst F R,Demay M B , Kronenberg H M. Hormones and disorders of mineral metabolism. Larsen P R, Kronenberg H M, Melmed Sh, Polonsky K S. Williams Textbook of Endocrinology. 10TH ed: Saunders, 2003.1317-1319
Shoback D,Marcus R, Bikle D. Metabolic bone diseases . Greenspan F S, Gardner D G. Basic &Clinical Endocrinology 7TH ed: Mc Graw- Hill Co, 2004.304-311
rate research
Read More
To determine the prevalence of the metabolic syndrome in a sample of
apparently healthy people.
Cross-sectional study of 382 apparently healthy people attending Al-Assad
University Hospital clinics in Damascus (not as patients). Anthropometry (hei
ght, weight, waist
circumference, and blood pressure), fasting blood glucose, triglyceride and high density lipoprotein were
examined for all the participants, and then the prevalence of the metabolic syndrome was determined
according to International Diabetes Federation and National Cholesterol Education Program / Adult
Treatment Panel 3 definitions.
There are a lot of studies with conflicting results about the correlation between blood
levels of vitamin D and lipid profile (total cholesterol, LDLc, HDLc) and the effect of
treatment with vitamin D supplements on it. This study aimed to investig
ate the effect of
vitamin D and calcium supplements on lipid profile.
This study included 59 volunteers who received these supplements for prevention of
osteoporosis as a prescription from orthopedic doctors between 11/2016 to 1/2018. The
average of age was 49±8 years. The plasma values of TC, LDLc, HDLc were measured
using enzymatic colorimetric method ( Biosystems kits ) in Tishreen hospital before
treatment and after two months. The results were analyzed by T-Student test, and P value
<0.05 was considered significant. The mean plasma levels of LDLc before treatment were
(100.983 ±28.36) mg/dl, and after two months of treatment were (102.249±27.478) mg/dl,
and the difference was not significant. The mean plasma levels of HDLc before treatment
were (68.056 ±14.369) mg/dl and after two months of treatment were (62.715 ± 14.39)
mg/dl, and the difference was significant. We advise to measure plasma lipid levels during
treatment with these supplements depending on the changes that observed in this study.
In the present study, we measured DNMT3A levels, the
methylation enzyme, in blood samples from Syrian AML patients
and normal individuals using real-time quantitative polymerase
chain reaction, in order to determine the roles of DNMT3A in the
development of leukemia.
This study aimed to define the levels of vitamin D3 in postmenopausal women and
their relation with bone mineral density (BMD). The study included 83 women (48-81 year)
who visited the Department of radiology of Al Asad hospital in Lattakia. Bone m
ineral density of
the lumbar spine (L1–L4) and total hip was measured by dual-energy X-ray absorptiometry (DXA).
Blood samples were collected to assay 25(OH)D3 and Ca.
The mean level of 25(OH)D3 was 18.87 ng/ml (6.96 SD) and the prevalence of
vitamin D3 difficiency { 25(OH)D3<20 ng/ml} was 64%. No correlation was found
between BMD and 25(OH)D3 levels [P value>0.05], and no correlation was found between
25(OH)D3 and age or body mass index (IMD). We found a strong correlation between
25(OH)D3 and duration of sun exposure (P value = 0.01). Conclusion: Hypovitaminosis D3
is very common among postmenopausal women. Vitamin D33 status may not be an
important determinant of bone health.
Gene regulation by microRNAs (miRNAs) is one of the most important regulatory
networks which control normal hematopoiesis. Disturbances in miRNAs levels lead to
proliferation diseases including leukemogenesis. MicroRNAs is a major topic of many
ca
ncer researches performed to discover noninvasive biomarkers used for diagnosis,
prognosis, and optimization of clinical decision.
This study, the first to be performed in Syria, aimed at monitoring miR-155 levels
compared to a normalizer gene RNU6-2 by quantitative reverse transcriptase -PCR (qRTPCR)
in a sample of newly diagnosed untreated AML patients at several hospitals in
Damascus in comparison with healthy controls. Changes in miR-155 gene expression
levels were calculated in patients and controls using the 2-ΔCt method.
The most important finding was the association of low and very high miR-155 levels
with poor prognosis reflected in failure to accomplish complete remission and high
mortality. In addition, high miR-155 levels were associated with M4 AML subtype,
although with large variance among patients. We hope our preliminary study pave the road
for many future research studies related to the applicability of microRNAs in supporting
diagnosis, predicting prognosis, and enhancing the personalized therapies which deal with
patients as individual cases.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
