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Register a new userThe effect of treatment with vitamin D and calcium supplements on blood levels of LDLc and HDLc
دراسة تأثير المعالجة بمستحضرات فيتامين د والكالسيوم على مستويات LDLc و HDLc الدموية
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Tishreen University ورقة بحثية
Publication date
2018
fields
Pharmacy
and research's language is
العربية
Authors
رنا ماخوس( باحث )
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Shamra Editor
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هناك عدة دراسات متناقضة عن العلاقة بين مستويات فيتامين د الدموية و صيغة شحوم الدم (الكولسترول الكلي، LDLc، HDLc) و عن تأثير المعالجة بمستحضراته عليها، لذلك كان الهدف من هذه الدراسة التحري عن وجود تأثير لتناول المستحضرات الحاوية على فيتامين د و الكالسيوم على صيغة شحوم الدم. شملت هذه الدراسة 59 متطوعاً ممن وصف لهم مستحضر حاوٍ على فيتامين د و الكالسيوم للوقاية من ترقق العظام من قبل أطباء المفاصل و العظام في الفترة الواقعة بين 11/ 2016 حتى تاريخ 1/ 2018، كان متوسط عمر المتطوعين ±849 عاماً. تمت معايرة مستويات TC و LDLc و HDLc الدموية باستخدام عتائد معايرة من شركة Bio Systems بالاعتماد على مقايسة أنزيمية لونية باستعمال أجهزة التحليل الآلي الموجودة في مشفى تشرين الجامعي و ذلك قبل البدء بالمعالجة و بعد شهرين من المعالجة. تمت معالجة النتائج احصائياً باستعمال اختبار T-Student عند مستوى دلالة 5%. كان متوسط قيم LDLc البلاسمية عند عينة الدراسة قبل المعالجة 28.36) 100.983 ±) ملغ/دل و بعد المعالجة بشهرين أصبحت 102.249±27.478 ملغ/دل و لم يكن الفرق هام احصائياً، أما بالنسبة لمستويات HDLc البلاسمية، فقد كانت قبل المعالجة ±14.369) 68.056) ملغ/دل، و بعد المعالجة بشهرين أصبحت (14.39 62.715 ±) ملغ/دل، و لقد كان الفرق هام إحصائيا. نوصي بمراقبة صيغة شحوم الدم أثناء المعالجة بهذه المستحضرات نتيجة التغيرات الملاحظة وفق هذه الدراسة.
There are a lot of studies with conflicting results about the correlation between blood levels of vitamin D and lipid profile (total cholesterol, LDLc, HDLc) and the effect of treatment with vitamin D supplements on it. This study aimed to investigate the effect of vitamin D and calcium supplements on lipid profile. This study included 59 volunteers who received these supplements for prevention of osteoporosis as a prescription from orthopedic doctors between 11/2016 to 1/2018. The average of age was 49±8 years. The plasma values of TC, LDLc, HDLc were measured using enzymatic colorimetric method ( Biosystems kits ) in Tishreen hospital before treatment and after two months. The results were analyzed by T-Student test, and P value <0.05 was considered significant. The mean plasma levels of LDLc before treatment were (100.983 ±28.36) mg/dl, and after two months of treatment were (102.249±27.478) mg/dl, and the difference was not significant. The mean plasma levels of HDLc before treatment were (68.056 ±14.369) mg/dl and after two months of treatment were (62.715 ± 14.39) mg/dl, and the difference was significant. We advise to measure plasma lipid levels during treatment with these supplements depending on the changes that observed in this study.
References used
EMELIA, J. B., et al. Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association. Circulation U.S.A , Vol. 135, N° 10, 2017, 1-9
BRUNTON, L.L., et al. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12th ed, McGraw-Hill Companies, China, 2011, 972-1005
GUYTON,A.C., HALL, E.J. Text book of medical physiology. 11th ed , Elsevier Inc, Philadelphia, 2006, 978-995
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