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Register a new userInsulin Resistance in Patient with Impaired Fasting Glucose IFG: Is It cause or Result?
المقاومة للأنسولين عند مرضى اضطراب تحمّل الغلوكّوز الصّيامي : IFG هل هي سبب أم نتيجة؟
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Tishreen University ورقة بحثية
Publication date
2015
fields
Medicine
and research's language is
العربية
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Shamra Editor
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شملت الدّراسة 200 حالة من الأشخاص البالغين الأصحّاء ظاهريّاً المراجعين مستشفيات جامعة دمشق، مرافقي المرضى، طلّاب الطّب و عناصر التّمريض و أطبّاء الدّراسات العليا، ممّن يزيد عمرهم على 18 عاماً و من الجنسين خلال عام 2015، تمّ استبعاد 11 حالة شُخّص لهم داء سكّري، 35 حالة فقر دم، و بذلك تمّت الدّراسة على 154 حالة. بيّنت الدّراسة أنّ معدّل انتشار ما قبل السّكّري 14,9% Prediabetes ، و كانت نسبة إصابة الإناث أعلى من نسبة إصابة الذّكور بنسبة 9,1% مقابل 5,8% على التّوالي. بينما كان معدّل انتشار اعتلال الغلوكّوز الصّيامي IFG هو 9,1%، و كانت أكثر فئة عمريّة إصابة هي بين 47-38 عاماً، و كانت أكثر العوامل تواجداُ عند المرضى هي البدانة، البدانة المركزيّة، ارتفاع شحوم الدّم و ارتفاع الضّغط الشّرياني. كما بيّنت الدّراسة ارتفاع مستويات الأنسولين الصّيامي و زيادة المقاومة للأنسولين عند مرضى IFG، و تبيّن وجود علاقة ارتباط خطّي طرديّة متوسّطة الشّدّة بين مستوى سكّر الدّم الصّيامي و درجة المقاومة للأنسولين. و ظهر أيضاً أنّه لا يُمكن معرفة فيما إذا كانت المقاومة للأنسولين سبباً أم نتيجة، بل يدخل المريض في دارة معيبة كلاهما يؤدّي للآخر.
The study included 200cases of apparently healthy adults attending hospitals of Damascus University, medical students, nurses and graduated doctors, whose aged over 18 years and of both genders during 2015, were excluded 11 cases of diagnosed diabetes, 35 cases of anemia, so the cases were 154. The study showed that the prevalence of prediabetes was 14,9%, and the prevalence on females was higher that on males (9,1% versus 5,8% respectively). While the prevalence of IFG was 9,1%, and mostly with the age group 38-47 year. The most risk factors in our study were obesity, central obesity,hypertriglyceridemia and high blood pressure. The study also showed high fasting insulin levels and increased insulin resistance in patients with IFG, and showed a moderate positive linear correlation between fasting blood glucose and insulin resistance. It also appeared that it could not determine if the insulin resistance is the cause or result, but the patient enters in defective circle.
Artificial intelligence review:
Research summary
تتناول هذه الدراسة مقاومة الأنسولين عند مرضى اضطراب تحمل الغلوكوز الصيامي (IFG) وتبحث فيما إذا كانت مقاومة الأنسولين سببًا أم نتيجة لهذا الاضطراب. شملت الدراسة 200 حالة من الأشخاص البالغين الأصحاء ظاهريًا الذين يراجعون مستشفيات جامعة دمشق، وتم استبعاد 46 حالة بسبب تشخيصهم بداء السكري أو فقر الدم، مما جعل العدد النهائي للحالات المدروسة 154 حالة. أظهرت النتائج أن معدل انتشار ما قبل السكري كان 14.9%، وكانت نسبة الإصابة بين الإناث أعلى من الذكور. بينما كان معدل انتشار IFG هو 9.1%، وكانت الفئة العمرية الأكثر إصابة هي بين 38-47 عامًا. كما أظهرت الدراسة ارتفاع مستويات الأنسولين الصيامي وزيادة مقاومة الأنسولين عند مرضى IFG، ووجود علاقة ارتباط خطية طردية متوسطة الشدة بين مستوى سكر الدم الصيامي ودرجة مقاومة الأنسولين. خلصت الدراسة إلى أنه لا يمكن تحديد ما إذا كانت مقاومة الأنسولين سببًا أم نتيجة، بل يدخل المريض في دائرة معيبة حيث يؤدي كل منهما إلى الآخر.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في فهم العلاقة بين مقاومة الأنسولين واضطراب تحمل الغلوكوز الصيامي (IFG). ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين عينة أكبر وأكثر تنوعًا من المشاركين لضمان تعميم النتائج بشكل أفضل. ثانيًا، لم تتناول الدراسة العوامل الوراثية التي قد تلعب دورًا في مقاومة الأنسولين وتطور IFG. ثالثًا، كان من الممكن أن تكون الدراسة أكثر شمولية إذا تم تضمين تحليل للعوامل البيئية مثل النظام الغذائي والنشاط البدني. وأخيرًا، كان من المفيد تقديم توصيات أكثر تحديدًا حول كيفية إدارة مقاومة الأنسولين والوقاية من تطور داء السكري من النوع 2.
Questions related to the research
-
ما هو معدل انتشار ما قبل السكري في الدراسة؟
معدل انتشار ما قبل السكري في الدراسة كان 14.9%.
-
ما هي الفئة العمرية الأكثر إصابة باعتلال الغلوكوز الصيامي (IFG)؟
الفئة العمرية الأكثر إصابة باعتلال الغلوكوز الصيامي (IFG) هي بين 38-47 عامًا.
-
هل يمكن تحديد ما إذا كانت مقاومة الأنسولين سببًا أم نتيجة لاضطراب تحمل الغلوكوز الصيامي (IFG)؟
لا يمكن تحديد ما إذا كانت مقاومة الأنسولين سببًا أم نتيجة، بل يدخل المريض في دائرة معيبة حيث يؤدي كل منهما إلى الآخر.
-
ما هي العوامل الأكثر شيوعًا بين مرضى اعتلال الغلوكوز الصيامي (IFG)؟
العوامل الأكثر شيوعًا بين مرضى اعتلال الغلوكوز الصيامي (IFG) هي البدانة، البدانة المركزية، ارتفاع شحوم الدم، وارتفاع الضغط الشرياني.
References used
American Diabetes Association. Report of expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care, 1997, 20, 1183-97
KUZUYA, T.; NAKAYAWA, S.; SATOH, J.; et al. Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pract, 2002, 55, 65-85
GAVIN, J. R.; ALBERTI KGMM, DAVIDSON, M. B.; DEFRONZO, R. A.; DRASH, A.; GABBE, S. G.; et al. Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care, 2003, 26(suppl 1), S5-S20
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ability to shift from one format to another to produce a new element with new
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This phenomenon crystallized clearly at the beginning of the industrial revolution,
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furniture has lured many people with its quick disappearing and appearing within the
interior space, but it remained at a lasting development it bordered the style format and
use. This raises the question about the purpose of producing these products, which
started to take the form of a type of fantasia and this became more important towards
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Serglycin is an intracellular proteoglycan in hematopoietic cells. It
has been studied in normal and tumor hematopoietic cell, so it was
suggested to have an important role in immunity and cancers as leukemia.
The challenge to make a diagnosis for
acute leukemia and to
differentiate between myeloid or lymphoblastic leukemia, is the reason
we go to assay concentration of serglyc in normal people and
patient with acute myeloid leukemia and acute lymphoblastic leukemia
from children and adult at hematology department in the
main hospitals in Damascus ( Pediatric’shopital, Almouasat and Al
asaad hospital) before beginning any kind of treatment and studying
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Background: Diabetes mellitus type2 (T2DM) and thyroid dysfunction (TD) are the
two most common endocrine disorders in clinical practice. The unrecognized TD may
adversely affect the metabolic control and add more risk to an already predisposing
s
cenario for cardiovascular diseases. The objective of this study was to investigate the
prevalence of TD in patients with type2 diabetes mellitus.
Objective: To determine the prevalence and patterns of thyroid dysfunction in
patients with type2 diabetes mellitus.
Material and methods: Study included total 362 subjects (204 type2 diabetic patients
and 158 healthy non diabetic subjects). Agroup of type2 diabetic patients and control group
were evaluated for thyroid dysfunction by testing TSH and FT4 when TSH was abnormal.
The correlation of prevalence of thyroid disorder with gender distribution, age distribution,
duration of diabetes, BMI, treatment, fasting plasma glucose (FPG), serum triglyceride and
serum cholesterol was then done in diabetic patients. The observations and interpretations
were recorded and results obtained were statistically analyzed.
Results: The prevalence of thyroid dysfunction among type2 diabetic patients was
found to be 13,2%. In the control group, the prevalence of thyroid dysfunction was 6,3%.
There was a significant difference between diabetics and control subjects p= 0,031.The
most frequently TD in type2 diabetic patients was subclinical hypothyroidism (8,3%).
Thyroid dysfunction was significantly correlated with gender (women > man), age < 60
years, FPG > 130mg/dl, TG > 150mg/dl and insulin treatment in type2 diabetic patients.
Conclusion: Screening of thyroid dysfunction shoud be done in all Type2 diabetic
patients.
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