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Register a new userAnti-D or Methylprednisolone? Pros and Cons in the Treatment of Acute Immune Thrombocytopenic Purpura in Children
أضداد الريزوس أم الميتيل بريدنزولون؟ الايجابيات و السلبيات في علاج فرفرية نقص الصفيحات المناعي الحادة عند الأطفال
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Damascus University ورقة بحثية
Publication date
2012
fields
Medicine
and research's language is
العربية
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Shamra Editor
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استوحينا فكرة مقارنة فعالية أضداد الريزوس الوريدية كجرعة عليا وحيدة بالميتيل بريدنيزولون بثلاث جرعات متتالية من حيث: 1. سرعة رفع تعداد الصفيحات. 2. استمرارية الفعالية الدوائية مدة ستة أشهر. 3. تخفيض التأثيرات الجانبية، مدة الاستشفاء و التكلفة.
the research performed by the ITP study group in 2006[15] studying the efficacy of single dose IV-Rhesus antibodies (Anti-D) "50 ug/kg or 75 ug/kg" compared to the single dose IVIG "800 mg/kg"; that study revealed that both have a similar therapeutic effect. that study suggest to compare the single high dose of Anti-D withthree consecutive doses of Methyl-prednisolone in respect of: 1- Time of platelet recovery 2- The continuity of mediation effect throughout ( 6 months) 3- Side effects, hospitalization and cost.
References used
Kurtzberg J, Stockman JA 3rd. ITP. AdvPediatr 1994; 41:111
Carcao MD, et al. Fcgamma receptor IIa andIIIa polymorphisms inITP. Br J Haematol 2003; 120:135
Kühne T, et al. A prospective comparative study of 2540 infants and children with newly diagnosed ITP from the Intercontinental Childhood ITP Study Group. J Pediatr 2003; 143:605
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Asthma exacerbations can be frequent and range in severity from relatively mild to
status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the
informations available on its inhaled role still low and conflicting, so the st
udy aim to
investigate the effect of thecombinationof MgSO4and salbutamol in the management of
acute asthma attack.
A randomized clinical trial was conducted on 76 patients, divided into two groups:
experimental (40) and control (36) patients. The trial received nebulised salbutamol with
magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three
sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse,
Sao2 and PEF were assessed.
Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2
and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4
in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects
attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with
salbutamol, appears to have benefits in the treatment of acute asthma attack.
Asthma is the most common chronic disease in childhood, the
incidence progresses and constitutes a public health problem which needs
the research of factors that increase the incidence and severity of crisis, and
among these factors IgG4 deficiency. Therefore the objective of the study is
to know the effect of IgG4 deficiency on severity and evolution of asthma in
children.
This study was done to determine whether use of nebulized salbutamol therapy for
treatment of an acute attack of asthma in children is associated with hypokalaemia and if
so what is its frequency, severity and what is accompanying clinical symptoms
103 child,
aged 3 years to 14 years with asthma attack, treated with three doses of nebulized
salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium
was obtained at the beginning and after three doses of nebulized salbutamol therapy.The
mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A
decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild
hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate
hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was
accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15,
headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate
hypokalemia.
The objective of this research is to insist on the most important symptoms and signs
of appendicitis and diagnosis in a timely manner to avoid complications and deaths. The
aim of the study was to establish diagnostic criteria for acute appendiciti
s in children in the
light of the data obtained from the study of a large number of patients with appendicitis
and to determine the surgical indication to reduce complications and negative abdominal
opening and to include the studied criteria in a spec
ial scale in our patients to evaluate children with acute appendicitis depending On
this scale. The study included 104 children who visited the Pediatric emergency
department at Al-Assad University and University Hospital and Tishreen university
Hospital with a complaint of abdominal pain between 2014 and 2016. The number of male
patients was 76 patients and 28 females, abdominal pain was present in all patients, The
following criteria were studied (abdominal pain, abdominal tenderness, rebound
tenderness, ultra sound, leukocytosis, shift to left, fever,crp). These criteria were studied to
diagnose acute appendicitis and to put them in a special scale for use in diagnosis or denial
acute appendicitis. In comparison with international standards, we observed that the scale
studied in our study is more objective and eliminates the subjective factor in the diagnosis
of appendicitis.
Introduction: Urinary tract infections are very common in childhood (especially under the age of 5 years) and because of the large number of complications resulting from it (renal failure – hypertension- kidney scarring) had to be diagnosed and early
treatment, although that urine culture is the standard Golden diagnosis, but its results are late to appear, Many studies have indicated an accompanying increase in platelet counts in urinary tract infections, so that platelet counts may be a vital indicator directed to it without asylum to the costly analyzes in its diagnosis. Objective: the objective of the following study is to assess the sensitivity and specificity of the plate count (PLT) in UTI. Methods: The study included 65 Patients (14 males, 51females) They were between (3-6) year with upper urine tract infections were diagnosed through symptoms, urological test, Serum tests, and radiology, who were admitted to the pediatric department at Tishreen University Hospital in Lattakia City. PLT was obtained through a complete CBC blood count (sensitivity and sensitization), and comparison of the ratio Percentage of Thrombocytosis between urine culture with Gram-positive germs and Gram-negative germs. Results: The study showed a good sensitivity=80.39% [75–84] to platelet counts compared to urine culture. it also showed statistically significant paper p-value=0.003 between platelet count and type of pathogen (positive or negative Gram) and the increase was more favorable to positive urine culture. Also showed that the average value of platelets is higher in culture a positive gram 521.9±90.9 x103 platelet/mcl than in gram negative 432.3±73.5 x103 platelet/mcl. Conclusion: higher Platelet numbers are a good analysis or sensitivity for the diagnosis of upper urinary tract infection in children with reliable urinary symptoms to start treatment. So that we get the results of culture urine .and the higher platelet count must be taken gram positive bacteria into account.
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