The role of intravenous magnesium sulfate in reduce of hospitalization in asthmatic children with moderate severity exacerbation

Objective: Many children experience acute asthma exacerbations ,Many children also require hospitalization despite treatment in an emergency department with current standard therapy (corticosteroids ,and inhaled salbutamol). These hospitalizations may be avoided if effective adjunctive therapies can be developed to adequately treat severe exacerbations.

The effect of magnesium sulphate with salbutamol in the treatment of acute asthma attack

Asthma exacerbations can be frequent and range in severity from relatively mild to status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the informations available on its inhaled role still low and conflicting, so the study aim to investigate the effect of thecombinationof MgSO4and salbutamol in the management of acute asthma attack. A randomized clinical trial was conducted on 76 patients, divided into two groups: experimental (40) and control (36) patients. The trial received nebulised salbutamol with magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse, Sao2 and PEF were assessed. Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2 and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4 in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with salbutamol, appears to have benefits in the treatment of acute asthma attack.

Evaluation of oral health status among asthma children treated with Budesonide

Aim of study:The purpose of this study is to evaluate the effect of antiasthma drug (Budesonide) on oral health of asthmatic children during one year of treatment. Materials and Methods: Thirty children with asthma aged (5-10) years were selected from the children who presented to children´s section at AL-Assad University Hospital in Lattakia with medium asthma severity and they needed to use antiasthma inhaled drug (Budesonide).This study have evaluated dental caries, gingival bleeding, dental plaque and saliva pH for each child before and after treatment with Budesonide in (3-6-9-12) months. Results: The results showed increasing in DMFT, dmft indices ,gingival bleeding index and dental plaque after follow- up for 12 months.

The relationship between serum potassium deficiency and treatment by nebulized salbutamol during asthma attack in children

This study was done to determine whether use of nebulized salbutamol therapy for treatment of an acute attack of asthma in children is associated with hypokalaemia and if so what is its frequency, severity and what is accompanying clinical symptoms 103 child, aged 3 years to 14 years with asthma attack, treated with three doses of nebulized salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium was obtained at the beginning and after three doses of nebulized salbutamol therapy.The mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15, headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate hypokalemia.

IgG4 Deficiency in Childhood Asthma

Asthma is the most common chronic disease in childhood, the incidence progresses and constitutes a public health problem which needs the research of factors that increase the incidence and severity of crisis, and among these factors IgG4 deficiency. Therefore the objective of the study is to know the effect of IgG4 deficiency on severity and evolution of asthma in children.